EP07.01: The effect of vanishing twin on the first and second trimester maternal serum makers and nuchal translucency: a multicentre prospective cohort study

Lee, S.; Jung, Young Mi; Jisu, S.; Han, You Jung; Kim, M.; Shim, Jae-Yoon; Lee, M.; Oh, So Yeon; Lee, J.; Kim, S.; Hyun, Dong; Cho, G.; Kwon, Han Sung; Kim, B.; Park, M.; Cho, H.; Ko, Hyun Sun; Park, C.; Park, J.; Jun, Jong Kwan; Ryu, Hyun Mee

doi:10.1002/uog.19878

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“…In a retrospective case-control study by Huang et al [7], the concentration of uE3 did not change during the second trimester. In addition, the study reported by Lee et al [21] reported the same result that the uE3 concentration did not change in VT [21].…”

Section: Unconjugated Estriolmentioning

confidence: 67%

The effect of a vanishing twin on first- and second-trimester maternal serum markers and ultrasound screening for aneuploidy

Lee,

Lee

2023

Obstet Gynecol Sci

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A vanishing twin (VT) is the early demise of a twin fetus. It is estimated to occur in 20-30% of pregnancies associated with assisted reproductive technology. VT becomes increasingly prominent when assisted fertilization is used, because one or more embryos are transferred to the uterus. Maternal serum screening tests during pregnancy can screen for trisomy chromosomes 21, 18, and 13 and are divided into first- and second-trimester tests. In singleton pregnancies, the first trimester screening test is performed at 11-13 weeks and 6 days of gestation. It consists of two serum markers, pregnancy-associated plasma protein A and β-human chorionic gonadotropin (β-hCG), and measures nuchal translucency thickness. The second-trimester screening test was performed at 15-20 weeks and 6 days of gestation. It consists of four serum markers: alpha-fetoprotein, β-hCG, unconjugated estriol, and inhibin A. More effective screening for trisomy 21 in singleton pregnancies is achieved by analyzing cell-free DNA in the maternal blood. A VT includes a demise of the fetus. Although it affects maternal serum markers, it has not been corrected. Five studies examined the effect of VT on maternal serum markers, but the results were controversial. This study aimed to review the patterns of changes in maternal serum markers in VTs, interpret prenatal tests for pregnant women with VTs in clinical practice, and consider what information should be provided.

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Section: Unconjugated Estriolmentioning

confidence: 67%