Oral communication abstractsConclusions: The usage of 17th-OHPC effectively reduces the incidence of recurrent preterm delivery in those patients with a cervical length ≥25mm at the time of enrolment. However, it is not effective in those with a cervix <25mm at the time of inclusion.Supporting information can be found in the online version of this abstract OC10.08 *

Conclusions: The overall prognosis of HF remains poor, but differs strongly according to the etiology. Advances in diagnostics and fetal therapy allow to differentiate between treatable and non-treatable HF. Neonatal OS is higher in treatable HF compared to non-treatable and idiopathic HF. OC14.02 Association between maternal systemic lupus erythematous and congenital malformations of the circulatory system

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The aim of the study is to determine the correlation of prenatal stomach position (SP) and presence of pulmonary hypertension (PH) in fetuses with left-sided congenital diaphragmatic hernia (LCDH). Methods: Fetuses with isolated LCDH (2007-2018) were evaluated from 19 weeks' gestational age (GA) onwards. SP was assessed on stored 2D ultrasound (US) data and scored 1-4 (grade 1: abdominal; grade 2: anterior in chest; grade 3: mid to posterior in the chest and grade 4: retrocardiac) in accordance to the grading system proposed by Cordier et al. Primary outcome was pulmonary hypertension (PH). Secondary analysis included the predictive value of SP together with the combination of observed-to-expected lung-to-head ratio (O/E LHR) and prenatal liver position for PH and the postnatal defect size. Results: 87 fetuses with LCDH were eligible for inclusion of which the SP could be graded for 46 fetuses at 20 weeks' GA (US1) and 72 fetuses at 30 weeks' GA (US2). At US2, 15 fetuses (21%) showed a grade 1, 17 (24%) a grade 2, 38 (53%) a grade 3 and 2 (2%) a grade 4 SP. Postnatally, 61 (70%) infants met the criteria for PH diagnosed by echocardiogram, whilst 26 (30%) of infants showed clinical symptoms requiring treatment. Need for treatment of PH was significantly different amongst SP grades both at US1 (p < 0.01) and US2 (p = 0.04) GA. SP grade 2 at US1 was predictive for the need for treatment of PH (p = 0.01), whereas other grades were not. Multivariable regression analysis showed that the addition of O/E LHR and liver position was not relevant in the association between SP grade and need for treatment of PH (p = 0.78). In addition, the postnatal defect size was significantly larger amongst groups with higher SP grades at US1 (p = 0.03) and US2 (p = 0.02). Conclusions: The grade of stomach position in LCDH fetuses can be used to predict necessity of treatment of PH. In addition, the postnatal defect size is positively correlated to SP grade.