Eph-B4 Mediates Vein Graft Adaptation By Regulation of eNOS

Wang, Mo; Collins, Michael J.; Bai, Hualong; Brownson, Kirstyn E.; Foster, Trenton R.; Hashimoto, Takeji; He, Huaqiang; Hu, Haidi; Shalaby, Sherif; Dardik, Alan

doi:10.1016/j.jvs.2015.06.057

Cited by 1 publication

(4 citation statements)

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“…We have shown that eNOS is likely to be an essential downstream mediator of EphB4 signaling that occurs during venous adaptation to the arterial environment (Wang et al, 2015). Stimulation of EphB4 with monomeric eph-rinB2/Fc or clustered ephrinB2/Fc resulted in increased eNOS phosphorylation, NO production, and cell migration in vitro; these effects were abolished in the presence of an eNOS inhibitor.…”

Section: Ephb4 and Ephrinb2-associated Signalingmentioning

confidence: 99%

“…These data suggest that EphB4 regulates endothelial cell functions by eNOS phosphorylation. In a mouse vein graft model, loss of EphB4 during vein graft adaptation was associated with increased eNOS activity and adaptive vein graft wall thickening (Wang et al, 2015). …”

Section: Ephb4 and Ephrinb2-associated Signalingmentioning

confidence: 99%

“…NO production is also a downstream mediator of EphB4-dependent vein graft remodeling (Muto et al, 2011; Wang et al, 2015). In vein grafts with reduced EphB4 activity, there is reduced eNOS phosphorylation (Jadlowiec et al, 2013).…”

Section: Membrane Signaling In Human Vascular Physiology and Pathophymentioning

confidence: 99%

“…In vein grafts with reduced EphB4 activity, there is reduced eNOS phosphorylation (Jadlowiec et al, 2013). NO is a known regulator of vein graft wall thickness (Kibbe et al, 2001) and animal models lacking eNOS show inhibited remodeling (Wang et al, 2015). …”

Section: Membrane Signaling In Human Vascular Physiology and Pathophymentioning

confidence: 99%

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Membrane‐mediated regulation of vascular identity

Hashimoto

Foster

Santana

et al. 2016

Birth Defects Research Pt C

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Vascular diseases span diverse pathology, but frequently arise from aberrant signaling attributed to specific membrane-associated molecules, particularly the Eph-ephrin family. Originally recognized as markers of embryonic vessel identity, Eph receptors and their membrane-associated ligands, ephrins, are now known to have a range of vital functions in vascular physiology. Interactions of Ephs with ephrins at cell-to-cell interfaces promote a variety of cellular responses such as repulsion, adhesion, attraction, and migration, and frequently occur during organ development, including vessel formation. Elaborate coordination of Eph-and ephrin-related signaling among different cell populations is required for proper formation of the embryonic vessel network. There is growing evidence supporting the idea that Eph and ephrin proteins also have postnatal interactions with a number of other membraneassociated signal transduction pathways, coordinating translation of environmental signals into cells. This article provides an overview of membrane-bound signaling mechanisms that define vascular identity in both the embryo and the adult, focusing on Eph-and ephrin-related signaling. We also discuss the role and clinical significance of this signaling system in normal organ development, neoplasms, and vascular pathologies.

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Section: Ephb4 and Ephrinb2-associated Signalingmentioning

confidence: 99%

Section: Ephb4 and Ephrinb2-associated Signalingmentioning

confidence: 99%