EphB4 is developmentally and differentially regulated in blood vessels throughout the forebrain neurogenic niche in the mouse brain: Implications for vascular remodeling

Colín-Castelán, Dannia; Phillips-Farfán, Bryan V.; Gutiérrez‐Ospina, Gabriel; Fuentes-Farías, A.L.; Báez-Saldaña, Armida; Padilla-Cortés, Patricia; Meléndez‐Herrera, Esperanza

doi:10.1016/j.brainres.2011.01.110

Cited by 12 publications

(12 citation statements)

References 27 publications

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“…We showed that astrocytes are first located at the outer border of the RMS, the region that harbors a high density of BVs and where the first parallel BVs appear. It has been shown previously that RMS astrocytes are derived from radial glia (Alves et al, 2002) and locate at the RMS outer border during the first 2 postnatal weeks (Law et al, 1999;Peretto et al, 2005), that the vasculature undergoes reorganization during postnatal development (Colín-Castelán et al, 2011), and that proliferative cells are mostly located at the border of the migratory stream (Pencea and Luskin, 2003). Our results, together with those of previous reports, thus strongly suggest that the developing RMS is compartmentalized, with its central, more "static" region containing a high density of nonproliferative and barely migrating neuroblasts and its outer border displaying active cellular reorganization.…”

Section: Development Of the Postnatal Migratory Streammentioning

confidence: 95%

Astrocytes Control the Development of the Migration-Promoting Vasculature Scaffold in the Postnatal Brain via VEGF Signaling

Bozoyan

Khlghatyan²,

Saghatelyan³

2012

J. Neurosci.

119

115

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Section: Development Of the Postnatal Migratory Streammentioning

confidence: 95%

Astrocytes Control the Development of the Migration-Promoting Vasculature Scaffold in the Postnatal Brain via VEGF Signaling

Bozoyan

Khlghatyan²,

Saghatelyan³

2012

J. Neurosci.

119

115

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“…Because SVZ-born progenitors and neuroblasts out-migrate from the SVZ to their designated targets at the OB, we find it appropriate to also discuss the essential role of blood vessels in guiding stereotyped migration of these neuronal cells along the RMS. To serve as scaffolds for neuronal migration (Whitman et al, 2009), RMS vessels have a unique architecture, oriented parallel to each other in a caudal-to-rostral direction (Bozoyan et al, 2012;Colin-Castelan et al, 2011; and see Fig. 1C).…”

Section: The Svz Vascular Nichementioning

confidence: 97%

“…Another candidate endothelial factor that may play a role in the SVZ and RMS is EphB4 that while widely expressed in the endothelium of the developing brain, its expression becomes progressively restricted to include only the SVZ and RMS vasculatures during early postnatal life and only SVZ vessels in the adult brain (Colin-Castelan et al, 2011).…”

Section: The Svz Vascular Nichementioning

confidence: 99%

The vascular niche in adult neurogenesis

Licht

2015

Mechanisms of Development

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Blood vessels (BVs) not only serve as conduits for oxygen and nutrients but may also fulfill perfusion-independent functions. A growing body of data suggests that blood vessels are an integral component of stem cell niches, including stem cell niches in the adult brain. This review summarizes in vivo studies supporting the contention that blood vessels may indeed control function of neuronal stem cells (NSCs) residing in the two major neurogenic niches of the adult brain, namely the sub-ventricular zone and the hippocampus. The review discusses different modes of BV-NSC communication and possible mechanisms by which BV may modulate NSC behavior and responses to external stimuli.

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“…The studies examining structural features and arrangement of blood vessels in the presumptive forebrain neurogenic region of mice during development revealed that blood vessels re-orient during the early embryonic stages and become more complex as development proceeds [ 67 , 68 ]. At E14.5, radially-oriented blood vessels predominate in this region.…”

Section: Development and Vascularization Of The Telencephalon And The Rostral Migratory Stream During The Embryogenesis Of Rodentsmentioning

confidence: 99%

Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain

Martončı́ková

Matiašová

Ševc

et al. 2021

IJMS

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Neural precursors originating in the subventricular zone (SVZ), the largest neurogenic region of the adult brain, migrate several millimeters along a restricted migratory pathway, the rostral migratory stream (RMS), toward the olfactory bulb (OB), where they differentiate into interneurons and integrate into the local neuronal circuits. Migration of SVZ-derived neuroblasts in the adult brain differs in many aspects from that in the embryonic period. Unlike in that period, postnatally-generated neuroblasts in the SVZ are able to divide during migration along the RMS, as well as they migrate independently of radial glia. The homophilic mode of migration, i.e., using each other to move, is typical for neuroblast movement in the RMS. In addition, it has recently been demonstrated that specifically-arranged blood vessels navigate SVZ-derived neuroblasts to the OB and provide signals which promote migration. Here we review the development of vasculature in the presumptive neurogenic region of the rodent brain during the embryonic period as well as the development of the vascular scaffold guiding neuroblast migration in the postnatal period, and the significance of blood vessel reorganization during the early postnatal period for proper migration of RMS neuroblasts in adulthood.

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EphB4 is developmentally and differentially regulated in blood vessels throughout the forebrain neurogenic niche in the mouse brain: Implications for vascular remodeling

Cited by 12 publications

References 27 publications

Astrocytes Control the Development of the Migration-Promoting Vasculature Scaffold in the Postnatal Brain via VEGF Signaling

Astrocytes Control the Development of the Migration-Promoting Vasculature Scaffold in the Postnatal Brain via VEGF Signaling

The vascular niche in adult neurogenesis

Relationship between Blood Vessels and Migration of Neuroblasts in the Olfactory Neurogenic Region of the Rodent Brain

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