Epicardial Fat Thickness Is Associated with Non-Dipper Blood Pressure Pattern in Patients with Essential Hypertension

Şengül, Cihan; Çevik, Cihan; Özveren, Olcay; Duman, Dursun; Eroğlu, Elif; Oduncu, Vecih; Tanboğa, Halil İbrahim; Can, Mehmet Mustafa; Akgün, Taylan; Dindar, İsmet

doi:10.3109/10641963.2011.577488

Cited by 35 publications

(33 citation statements)

References 36 publications

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“…Although there were some differences in study populations and methods, results from several studies consistently supported the relationship between EAT and HTN [10,15,17,18]. Magnetic resonance imaging was used to show the existence of a link between EAT and HTN, atherosclerosis, and CAD [19].…”

Section: Discussionmentioning

confidence: 99%

“…Computerized tomography findings showed hypertensive patients to have significantly thicker EAT compared to normotensive patients in a study of 127 asymptomatic patients with one or more cardiovascular risk factors [15]. Echocardiographic measurements performed in outpatient clinics indicated that increased EAT thickness may influence circadian patterns of blood pressure, and correlates with an increased prevalence of nocturnal nondipping patterns [18]. Finally, MDCT studies of patients with CAD showed significantly higher mean EAT than those without CAD, and that PAT was significantly correlated with BMI, HTN, and DM history [10].…”

Section: Discussionmentioning

confidence: 99%

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Maximal pericoronary adipose tissue thickness is associated with hypertension in nonobese patients with acute or chronic illness

Chang¹,

Lee²,

Kwag³

et al. 2017

Korean J Intern Med

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Background/AimsRecent studies have shown an association of epicardial fat thickness with diabetes and hypertension (HTN) in asymptomatic populations. However, there is lack of information as to whether there is similar association between pericoronary adipose tissue (PAT) and HTN in the patients who have acute or chronic illness.MethodsThis study included 214 nonobese patients hospitalized with acute or chronic noncardiogenic illness. PAT thicknesses were measured from fat tissues surrounding left and right coronary arteries in enhanced, chest computed tomography scans, yielding the maximal PAT value from left and right coronary arteries was used for analysis. Baseline data from hypertensive (n = 81) and normotensive (n = 133) patients were collected and compared.ResultsPAT is positively correlated with age (r = 0.377, p <0.001), body mass index (BMI; r = 0.305, p < 0.001), systolic blood pressure (r = 0.216, p = 0.001), and total cholesterol (r = 0.200, p = 0.006). The hypertensive group was older (69.58 ± 11.69 years vs. 60.29 ± 14.98 years), and had higher PAT content (16.30 ± 5.37 mm vs. 13.06 ± 5.58 mm) and BMI (23.14 ± 3.32 kg/m2 vs. 20.96 ± 3.28 kg/m) than the normotensive group (all p < 0.001). Multivariate analysis showed that age (odds ratio [OR], 2.193; p = 0.016), PAT thickness (OR, 1.065; p = 0.041), and BMI (25 ≤ BMI < 30 kg/m2 ; OR, 6.077; p = 0.001) were independent risk factors for HTN.ConclusionsIn nonobese patients with noncardiogenic acute or chronic illness, PAT thickness is independently correlated with HTN, age, and BMI.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Maximal pericoronary adipose tissue thickness is associated with hypertension in nonobese patients with acute or chronic illness

Chang¹,

Lee²,

Kwag³

et al. 2017

Korean J Intern Med

View full text Add to dashboard Cite

show abstract

“…Consequently, increased EFT was independently associated with impaired diurnal BP profiles in individuals with hypertension resulting from autonomic dysfunction, sympathetic overactivity, and inflammation 26)27). The lack of decrease in nocturnal BP, known as non-dipping, is associated with lower adiponectin levels than measured in hypertensive dippers28) as well as an increased risk of CV events 1)2).…”

Section: Discussionmentioning

confidence: 99%

Epicardial Fat Thickness and Neutrophil to Lymphocyte Ratio are Increased in Non-Dipper Hypertensive Patients

Kim

Cho

Choi

et al. 2016

J Cardiovasc Ultrasound

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BackgroundIn this study, we aimed to investigate the relationship between echocardiographic epicardial fat thickness (EFT), neutrophil to lymphocyte ratio (NLR; an important inflammatory marker), and diurnal blood pressure (BP) changes in patients with recently diagnosed essential hypertension.MethodsA total of 647 patients underwent echocardiography and 24 hours of ambulatory BP monitoring. EFT was measured by echocardiography, while NLR was measured by dividing the neutrophil count by the lymphocyte count. Patients were categorized into three groups according to BP pattern: the normotensive group, the dipper group, and the non-dipper group.ResultsThe mean EFT was highest in the non-dipper group (non-dipper group, 7.3 ± 3.0 mm; dipper group, 6.1 ± 2.0 mm; control group, 5.6 ± 2.0 mm; p < 0.001). NLR was also highest in the non-dipper group (non-dipper, 2.75 ± 2.81; dipper, 2.01 ± 1.32; control, 1.92 ± 1.11; p < 0.001). EFT was significantly correlated with age (r = 0.160, p < 0.001) and NLR (r = 0.353, p < 0.001). Furthermore, an EFT ≥ 7.0 mm was associated with the non-dipper BP pattern with 51.3% sensitivity and 71.6% specificity [95% confidence interval (CI) = 0.56–0.65, p < 0.001]. In a multivariate analysis, EFT [adjusted odds ratio (OR) = 3.99, 95% CI = 1.22–13.10, p = 0.022] and NLR (OR = 1.34, 95% CI = 1.05–1.71, p = 0.018) were independent parameters that distinguished a non-dipper pattern after adjustment for cardiovascular risk factors.ConclusionEFT and NLR are independently associated with impaired diurnal BP profiles in hypertensive individuals. EFT (as measured by echocardiography) and NLR appear to be helpful in stratifying cardiometabolic risk.

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“…EAT thickness measured by echocardiography correlates well with abdominal adiposity measured by computed tomography and MRI [12,13]. Previous studies have shown that EAT is thicker in hypertensive patients than in normotensive individuals [14,15]. In this study, we aimed to investigate the relation of EAT with RHT.…”

Section: Introductionmentioning

confidence: 97%

Assessment of epicardial adipose tissue thickness in patients with resistant hypertension

Erdoğan

Belen

Sungur

et al. 2016

Blood Pressure Monitoring

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Epicardial Fat Thickness Is Associated with Non-Dipper Blood Pressure Pattern in Patients with Essential Hypertension

Abstract: Epicardial fat thickness was above average in newly diagnosed, untreated hypertensive patients with non-dipper BP pattern. The echocardiographic measurement of EFT may be used to indicate increased risk of hypertension-related adverse cardiovascular events.

Cited by 35 publications

References 36 publications

Maximal pericoronary adipose tissue thickness is associated with hypertension in nonobese patients with acute or chronic illness

Maximal pericoronary adipose tissue thickness is associated with hypertension in nonobese patients with acute or chronic illness

Epicardial Fat Thickness and Neutrophil to Lymphocyte Ratio are Increased in Non-Dipper Hypertensive Patients

Assessment of epicardial adipose tissue thickness in patients with resistant hypertension

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