(−)-Epicatechin ameliorates type 2 diabetes mellitus by reshaping the gut microbiota and Gut–Liver axis in GK rats

Zeng, Hongzhe; Liu, Changwei; Wan, Liwei; Peng, Liyuan; Wen, Shuai; Fang, Wenwen; Chen, Hongyu; Wang, Kuofei; Yang, Xiaomei; Huang, Jian'an; Liu, Zhonghua

doi:10.1016/j.foodchem.2024.138916

Cited by 5 publications

(1 citation statement)

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“…Epicatechin, which is a prevalent flavonoid found in human dietary sources, is recognized for its role in enhancing insulin responsiveness and managing blood glucose levels [ 140 , 141 ]. Increases in AGEs are strongly associated with diabetic retinopathy [ 142 ].…”

Section: Natural Products In the Treatment Of Diabetic Retinopathymentioning

confidence: 99%

The Role of Natural Products in Diabetic Retinopathy

Zhao,

Chen,

Yan

2024

Biomedicines

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Diabetic retinopathy (DR) is one of the most severe complications of diabetes mellitus and potentially leads to significant visual impairment and blindness. The complex mechanisms involved in the pathological changes in DR make it challenging to achieve satisfactory outcomes with existing treatments. Diets conducive to glycemic control have been shown to improve outcomes in diabetic patients, thus positioning dietary interventions as promising avenues for DR treatment. Investigations have demonstrated that natural products (NPs) may effectively manage DR. Many types of natural compounds, including saponins, phenols, terpenoids, flavonoids, saccharides, alkaloids, and vitamins, have been shown to exert anti-inflammatory, antioxidant, anti-neovascular, and antiapoptotic effects in vivo and in vitro. Nevertheless, the clinical application of NPs still faces challenges, such as suboptimal specificity, poor bioavailability, and a risk of toxicity. Prospective clinical studies are imperative to validate the therapeutic potential of NPs in delaying or preventing DR.

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Section: Natural Products In the Treatment Of Diabetic Retinopathymentioning

confidence: 99%