(−)-Epicatechin<i>in vitro</i>ameliorates erythrocyte protein carbonyl content in hypertensive patients: comparison with L-ascorbic acid

Kumar, Navneet; Maurya, Pawan Kumar; Kant, Ruchi; Rizvi, Syed Ibrahim

doi:10.3109/13813455.2016.1159699

Cited by 5 publications

(3 citation statements)

References 42 publications

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“…RBCs from hypertensives were shown to be more affected by oxidative stress as indicated by a higher count of carbonyl groups in the RBC membranes of these patients [54]. However, our oxidative stress markers do not confirm a significant deterioration of either oxidative or carbonyl stress in our animals during aging as discussed previously [20].…”

Section: What Can Be Responsible For Differences In Rbc Deformability...mentioning

confidence: 41%

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Radošinská

Kollárová

Jasenovec

et al. 2023

Biology

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Erythrocyte deformability, crucial for oxygen delivery to tissues, plays an important role in the etiology of various diseases. As the factor maintaining the erythrocyte deformability, nitric oxide (NO) has been identified. Reduced NO bioavailability also plays a role in the pathogenesis of hypertension. Our aim was to determine whether aging and hypertension affect erythrocyte deformability and NO production by erythrocytes in experimental animals divided into six groups according to age (7, 20 and 52 weeks), labeled WKY-7, WKY-20 and WKY-52 for normotensive Wistar-Kyoto (WKY) rats, and SHR-7, SHR-20 and SHR-52 for spontaneously hypertensive rats (SHR). The filtration method for the determination of erythrocyte deformability and the fluorescent probe DAF-2 DA for NO production were applied. Deformability and NO production by erythrocytes increased at a younger age, while a decrease in both parameters was observed at an older age. Strain-related differences in deformability were observed at 7 and 52 weeks of age. SHR-7 had reduced deformability and SHR-52 had increased deformability compared with age-matched WKY. Changes in NO production under hypertensive conditions are an unlikely primary factor affecting erythrocyte deformability, whereas age-related changes in deformability are at least partially associated with changes in NO production. However, an interpretation of data obtained in erythrocyte parameters observed in SHRs of human hypertension requires precaution.

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Section: What Can Be Responsible For Differences In Rbc Deformability...mentioning

confidence: 41%

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Radošinská

Kollárová

Jasenovec

et al. 2023

Biology

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“…Diseases like atherosclerosis, hypertension, diabetes, neurodegeneration, and cancer Prabhanshu Kumar and Ridhima Wadhwa contributed equally. can be initiated by the disturbance of ROS/RNS homeostasis (Kumar et al 2016a;Maurya et al 2016c). Some doubts have been created due to the recent publications as to whether OS is the cause or consequence of aging process (Roake and Artandi 2017).…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic determination of intracellular quercetin uptake using erythrocyte model and its implications in human aging

et al. 2018

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The present study was carried out to detect intracellular quercetin uptake by RBCs during human aging. The study was carried out on 95 normal healthy subjects of both the sexes. Intracellular quercetin uptake was estimated by performing ethyl acetate extraction. A significant (p < 0.001) decline in intracellular quercetin uptake by human RBCs was observed in elderly as compared to young population, while plasma membrane redox system (PMRS) activity was significantly decreasing as a function of human age. To the best of our knowledge, we are the first to present quercetin uptake by erythrocytes during aging in humans with this study. It is hypothesized that intracellular uptake of quercetin may serve as an intracellular electron donor for plasma membrane redox system in red blood cells during cellular aging which plays an important role in extracellular dehydroascorbate reduction and ascorbate recycling.

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“…On the other hand, excessive intracellular levels of ROS/RNS, as well as a defective antioxidant system, can give rise to pathological conditions and contribute to the etiology of diverse human diseases, such as coronary heart disease, diabetes, and hypertension. 2,3 Aging leads to the accumulation of diverse detrimental changes in cells and tissues, resulting in an increased risk of disease and death. 1 There are more than three hundred theories that attempt to explain the process of aging.…”

Section: Introductionmentioning

confidence: 99%

Multi-target detection of oxidative stress biomarkers in quercetin and myricetin treated human red blood cells

et al. 2016

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(−)-Epicatechinin vitroameliorates erythrocyte protein carbonyl content in hypertensive patients: comparison with L-ascorbic acid

Abstract: We hypothesizes that a higher intake of (-)-epicatechin may provide protection against hypertension in males and females.

Cited by 5 publications

References 42 publications

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Aging in Normotensive and Spontaneously Hypertensive Rats: Focus on Erythrocyte Properties

Spectroscopic determination of intracellular quercetin uptake using erythrocyte model and its implications in human aging

Multi-target detection of oxidative stress biomarkers in quercetin and myricetin treated human red blood cells

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