Multi-target detection of oxidative stress biomarkers in quercetin and myricetin treated human red blood cells

Maurya, Pawan Kumar; Kumar, Prabhanshu; Nagotu, Shirisha; Chand, Subhash; Chandra, Pranjal

doi:10.1039/c6ra05121a

Cited by 14 publications

(7 citation statements)

References 45 publications

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“…Metallic NPs are widely employed in commercial products, so extensive studies have been carried out to know the underlying mechanism responsible for oxidative stress-mediated toxicity (Baranwal et al 2016). Range of biomarkers are available to assess level of oxidative stress in a cell (Maurya et al 2015(Maurya et al , 2016bKumar et al 2016;Maurya and Chandra 2017). These biomarkers are found to be elevated in a cell which is exposed to toxic concentration range of NPs.…”

Section: Cytotoxicitymentioning

confidence: 99%

Red blood cells as an efficient in vitro model for evaluating the efficacy of metallic nanoparticles

et al. 2019

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Blood and the linings of blood vessels may be regarded as a fifth tissue type. The human body contains 5 × 10 9 red blood cells (RBCs) per ml, a total of 2.5 × 10 13 cells in the 5 l of blood present in the body. With an average lifetime of 125 days, human RBCs are destroyed by leukocytes in the spleen and liver. Nowadays red blood cells are extensively used to study various metabolic functions. Nanoparticles (NP) are being widely accepted for drug delivery system. This review summarizes the red blood cells, NPs and their characteristics on the basis of the RBC components along with drug delivery systems through RBCs. Further, we also discussed that how erythrocytes can be used as an efficient in vitro model for evaluating the efficacy of various nanocomposite materials.

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Section: Cytotoxicitymentioning

confidence: 99%

Red blood cells as an efficient in vitro model for evaluating the efficacy of metallic nanoparticles

et al. 2019

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“…These radicals damage biological molecules including proteins or DNA, which disturbs healthy skin conditions. Because the biological barrier function is impaired by these repeated stresses [ 2 ] and endogenous anti-oxidative capacity is gradually decreased with age [ 3 ], the protection and treatment of skin conditions by daily supplements have received increasing attention [ 2 , 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People—A Randomized, Double-Blind, Placebo-Controlled Trial

2018

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Skin is a major safeguard tissue in humans. Because biological barrier function is deteriorated by several kinds of stresses including exposure to ultra-violet (UV) rays, the protection and treatment of skin conditions by dietary supplements are important. We therefore evaluated the effects of dietary supplementation with an algal food-derived antioxidant, astaxanthin, on UV-induced skin deterioration. Twenty-three healthy Japanese participants were recruited to a 10-week double-blind placebo-controlled study. They were assigned to the astaxanthin group supplemented with a capsule containing 4 mg of astaxanthin or the placebo group. To assess the protective role of astaxanthin for UV-induced skin deterioration, we determined the minimal erythema dose (MED) and analyzed UV-induced changes of moisture and transepidermal water loss (TEWL) at baseline and after 9 weeks of supplementation. Subjective skin conditions were assessed by the visual analog scale. The astaxanthin group showed increased MED compared with placebo. In addition, the astaxanthin group had a reduced loss of skin moisture in the irradiated area compared with placebo. Subjective skin conditions for “improvement of rough skin” and “texture” in non-irradiated areas were significantly improved by astaxanthin. Astaxanthin seems protective against UV-induced skin deterioration and helps maintain healthy skin in healthy people.

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“…The current study provides novel evidence of intracellular uptake of quercetin by human red blood cells during aging process. The rationale to compare intracellular uptake of quercetin in young with that of older age group was based on the expectation that quercetin could be a reliable antioxidant of cellular aging process (Maurya et al 2016b). It is important to understand the cellular effects of flavonoid metabolites to predict which dietary flavonoids shall be most beneficial (Kumar et al 2016c).…”

Section: Discussionmentioning

confidence: 99%

Spectroscopic determination of intracellular quercetin uptake using erythrocyte model and its implications in human aging

et al. 2018

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The present study was carried out to detect intracellular quercetin uptake by RBCs during human aging. The study was carried out on 95 normal healthy subjects of both the sexes. Intracellular quercetin uptake was estimated by performing ethyl acetate extraction. A significant (p < 0.001) decline in intracellular quercetin uptake by human RBCs was observed in elderly as compared to young population, while plasma membrane redox system (PMRS) activity was significantly decreasing as a function of human age. To the best of our knowledge, we are the first to present quercetin uptake by erythrocytes during aging in humans with this study. It is hypothesized that intracellular uptake of quercetin may serve as an intracellular electron donor for plasma membrane redox system in red blood cells during cellular aging which plays an important role in extracellular dehydroascorbate reduction and ascorbate recycling.

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Multi-target detection of oxidative stress biomarkers in quercetin and myricetin treated human red blood cells

Abstract: Quercetin and myricetin help against oxidative stress in human red blood cells during aging, thereby has tremendous scope in medical diagnostics and therapeutics.

Cited by 14 publications

References 45 publications

Red blood cells as an efficient in vitro model for evaluating the efficacy of metallic nanoparticles

Red blood cells as an efficient in vitro model for evaluating the efficacy of metallic nanoparticles

The Protective Role of Astaxanthin for UV-Induced Skin Deterioration in Healthy People—A Randomized, Double-Blind, Placebo-Controlled Trial

Spectroscopic determination of intracellular quercetin uptake using erythrocyte model and its implications in human aging

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