Epidemic, Endemic, or Stewart–Bluefarb? When Several Forms of Kaposi Seem to Dispute Paternity

Abstract

The role of human herpes virus 8 (HHV8) is demonstrated in the occurrence of Kaposi’s disease, but the role of cofactors is still hardly known. We report a case of Kaposi’s disease which occurred 10 years after a local trauma in an HIV-positive patient from Central Africa. A 38-year-old female, from and living in Central Africa, consulted for angiomatous papulo-nodules associated with purple-colored macules and painful lymphoedema of the right leg and foot that had been developing for 6 months. She reported a history of posttraumatic lymphoedema of the affected limb as a result of a road accident that occurred ten years earlier. The mucous were healthy. There was no sign of systemic lesions. The diagnosis of Kaposi’s disease was evoked with, in differential, a Stewart–Bluefarb syndrome-type of pseudo-Kaposi and an epidemic Kaposi disease. Retroviral serology was positive to HIV1 with a CD4 count of 600 cells/mm3. Histopathology of the lesions and duplex ultrasonography could not be performed. The rest of the biological assessment was without particularity. The diagnosis of epidemic Kaposi’s disease associated with cofactors involved in endemic Kaposi’s disease and Stewart–Bluefarb syndrome was retained. An antiretroviral treatment (emtricitabine, tenofovir, and efavirenz) allowed to obtain after 6 months a noticeable improvement of the lesions and a disappearance of the pain with however the persistence of a residual lymphoedema. This is a special case of Kaposi’s disease that seems to involve several factors. The role of cofactors in Kaposi’s disease remains to be elucidated.

Multiple acroangiodermatitis of the left big toe: A case report from the university clinic of dermatology-venereology of the national university hospital center Hubert Koutoukou MAGA of Cotonou in Benin

“…Managing this condition always involves a multidisciplinary approach, as was the case with our patient. This observation draws attention to clinicians when encountering any angiomatous mass in the extremities, always investigating the presence or absence of the notion of pathergy, which, once present, may suggest a diagnosis other than Kaposi's disease, as was the case with our patient, and always conducting an appropriate vascular examination to identify venous insufficiency [7][8][9] .…”

Immunoinformatics guided design of a universal epitope-based vaccine against Kaposi Sarcoma

“…These viruses can remain dormant in their host cells for an inde nite period of time. HHV-8/KSHV has seven recognized subtypes (A, B, C, D, E, F, and Z) [6]. The HHV-8 genome is around 170 kb in size and encodes about 81 ORFs [7].…”