Epidemiological analysis of data on the incidence of measles, whooping cough and mumps in the Republic of Dagestan for the period 2010–2020. A retrospective epidemiological analysis of the data on the incidence of measles, whooping cough and mumps in the Republic of Dagestan for the period 2010–2018 was carried out. Materials on the coverage of planned vaccinations are analyzed. Statistical data processing was performed using the MS Exсel 2010 software package. In 2020, in the Republic of Dagestan, the measles incidence rate per 100 thousand population was 16,43 compared to 27,0 in 2019, 79.5 % of those who were not vaccinated against measles accounted for — 53.1 % fell ill due to refusals. The peak rates of whooping cough incidence are observed in 2018–2019 (8.0 and 7.19, respectively, per 100 thousand of the population). The main contingent is children — 97.9 %, of which 96.3 % are due to parental refusal. In terms of the incidence of mumps, the Republic of Dagestan ranks first in 2017–2018 (87.15 and 45.3 per 100 thousand population), with an excess of the all-Russian indicator (2.19) by 39.8 times, that is, 68 % of those who have been ill in the country are residents of Dagestan. Among those who fell ill with mumps, the share of unvaccinated persons was 65.6 %, of which 78.4 % were children under 17 years of age with refusal of vaccination. Based on a retrospective epidemiological analysis of the incidence of measles, whooping cough and mumps in the Republic of Dagestan for the period 2010–2020, it can be concluded that the intensity of the epidemic process of these diseases has increased, which is an unfavorable prognostic sign. The main reason for the epidemiological problems and the spread of these infections among the population of the Republic of Dagestan is the increase in the number of refusals of preventive vaccinations. It is necessary to strengthen the educational and organizational activities of medical workers for the purpose of hygienic education of the population on the prevention of immune-controlled infections.