Epidemiología de las muertes prematuras en Chile en la década 2001-2010

Bächler, Roberto; Icaza, Gloria; Soto, Alex; Núñez, Loreto; Orellana, C Félix; Monsalve, Rolando; Riquelme, Marcela

doi:10.4067/s0034-98872017000300005

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…1 These considerations can be particularly important for cardiovascular diseases (CVD), such as high blood pressure (HBP), cardiac ischemia, or stroke, which are the third cause of dead in Chile. 2 Most of these CVD are associated with increased plasma levels of low-density lipoprotein cholesterol (LDL-C). 3 On this issue, LDL receptor (LDLR) plays an important role in the lipoprotein metabolism, since LDL-C is removed from blood vessels through LDLR endocytosis.…”

Section: Introductionmentioning

confidence: 99%

Characterization of LDLR rs5925 and PCSK9 rs505151 genetic variants frequencies in healthy subjects from northern Chile: Influence on plasma lipid levels

Rojas

Ramírez

Salazar

et al. 2019

Clinical Laboratory Analysis

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BackgroundIdentification and characterization of genetic variants and their effects on human health may allow to establish relationships between genetic background and susceptibility to developing cardiovascular diseases. LDLR and PCSK9 polymorphisms have been associated with higher lipid levels and risk of cardiovascular diseases. Thus, the main aim of this study was to evaluate genotype distribution and relative allelic frequency of LDLR rs5925 (1959C > T) and PCSK9 rs505151 (23968 A > G) genetic variants and their effects on lipid levels of healthy subjects from northern Chile.MethodsA total of 178 healthy individuals were recruited for this study. The genotyping of rs5925 (LDLR) and rs505151 (PCSK9) polymorphisms was performed by PCR‐RFLP and qPCR, respectively. In addition, glucose and lipid levels were determined and associated with the genetic data.ResultsGenotype distribution for LDLR rs5925 polymorphism was as follows: CC = 19%; CT = 53%; and TT = 28% (HWE: χ 2 = 0.80; P = .37), and for PCSK9 rs505151 genetic variant was as follows: AA = 93%; AG = 7%; and GG = 0% (HWE: χ 2 = 0.22; P = .64). The frequency of T (rs5925) and G (rs505151) mutated alleles was 0.55 and 0.03, respectively. Data showed that individuals carrying LDLR mutated allele (T) presented lower values of total cholesterol, triglycerides, and LDL‐cholesterol when compared to CC homozygous genotype (P < .05). Subgroup analysis revealed that women carrying the PCSK9 mutated allele (G) exhibited higher values of total cholesterol, triglycerides, HDL‐C, and LDL‐C when compared to male group carrying the same genotype (P < .05).ConclusionsThe effect of LDLR rs5925 and PCSK9 rs505151 gene polymorphisms on lipid levels is associated with gender among healthy subjects from northern Chile.

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Section: Introductionmentioning

confidence: 99%

Characterization of LDLR rs5925 and PCSK9 rs505151 genetic variants frequencies in healthy subjects from northern Chile: Influence on plasma lipid levels

Rojas

Ramírez

Salazar

et al. 2019

Clinical Laboratory Analysis

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“…Thirteen focus groups delivered in three rounds were conducted: nine with patients and four with team members. The total number of participants was 48 (24 patients and 24 team members) and the average number of participants per focus group was 5 (3)(4)(5)(6)(7). The average time per focus group was 64 minutes (58-72) Figure 1 summarizes the main barriers and facilitators for medication adherence that emerged from the focus groups.…”

Section: Qualitative Analysismentioning

confidence: 99%

The challenge of medication adherence to reduce cardiovascular risk in primary care: a mixed design multi-center study in underserved populations

Püschel

González

Varas

et al. 2023

Preprint

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Background: Cardiovascular disease is a leading cause of death in Latin America. Internationally, low medication adherence is associated with 15% to 40% of excess cardiovascular deaths. In Latin America, the magnitude of low medication adherence and the factors associated with it, are not well known, especially among socially vulnerable populations. The aim of this study is to estimate the magnitude and associated factors of low medication adherence in a socially vulnerable population with high cardiovascular risk in Chile. Methods: The study is based on a mixed-methods design. It included a multicenter cross-sectional design of a randomly selected clinical population of 900 participants, and a qualitative design based on the analytical framework model, that included patients and health team members, from three primary care clinics in Chile. Results: Only 24.6% from the 886 (out of 900) patients who completed the study had "high" medication adherence, 24.9% had "regular," and 50.4% had "low" adherence. Depression was the main factor associated with regular and low adherence combined (OR: 2.12; 95%CI:1.55-2.89). Confusion and tiredness were identified as barriers for adherence. Main facilitators reported by patients included better understanding of the medications, and availability of reminders. Clearer information and family support were identified by team members as initiators for improving adherence. Conclusion: Low medication adherence is highly prevalent among patients with high cardiovascular risk in a low-income population in Chile. Quantitatively, depression was a significant risk factor for regular and low adherence; qualitatively, confusion and tiredness were identified as barriers. Clearer information and family support are identified as potential facilitators.

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“…Cardiovascular disease is a growing epidemic in Latin America and remains the leading cause of death in the region (Lloyd-Sherlock et al, 2019). In Chile, cardiovascular disease is also the leading cause of death and accounts for 14% of premature deaths in the population (Bächler et al, 2017; OECD/The World Bank, 2023). According to a Chilean National Health Survey, 51% of the adult population is at moderate or high risk of cardiovascular disease (Ministerio de Salud, 2017).…”

Section: Introductionmentioning

confidence: 99%

Breaking the digital gap to reduce cardiovascular risk in primary care

González-Suitt,

Püschel,

Escalona

et al. 2024

Health Education Journal

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Objective: The goal of this study was to report on the development and early usability of a new interactive mHealth app for reducing cardiovascular risk in primary care patients of low socioeconomic status attending clinics in Chile. Design: Mixed-methods design with qualitative and quantitative components. Setting: Three Chilean primary care clinics located in one urban (Santiago) and two rural areas (San Clemente and Chiguayante). Each clinic serves a population of about 24,000 people of generally low socioeconomic status with an average of 8.5 years of education. Methods: A qualitative co-design participatory framework was used to develop the Mi Salud-APS mHealth app. Three iterations of virtual workshops were held with healthcare providers and patient participants to develop the new app. Once developed, the usability phase identified, invited and followed up for 3 months a sample of primary care patients with moderate ( N = 119) or high ( N = 329) cardiovascular risk. Results: A total of 24 healthcare providers and 24 patients participated in the developmental workshops. Three emergent categories represented the core attributes for the mHealth app design: ‘Friendly’, ‘Interactive’ and ‘Pertinent’. In the usability phase of the sample of 448 patients, 98% downloaded the app, and 64.6% of them logged in and used it for an average of 1.46 (0.5–10) times weekly. Conclusion: Findings suggest that patient and healthcare provider contributions to the development of the mHealth app accurately reflect the interests and experiences of both groups and together helped achieve the high usability levels observed among primary care patients enrolled in clinics in underserved communities.

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Epidemiología de las muertes prematuras en Chile en la década 2001-2010

Cited by 7 publications

References 18 publications

Characterization of LDLR rs5925 and PCSK9 rs505151 genetic variants frequencies in healthy subjects from northern Chile: Influence on plasma lipid levels

Characterization of LDLR rs5925 and PCSK9 rs505151 genetic variants frequencies in healthy subjects from northern Chile: Influence on plasma lipid levels

The challenge of medication adherence to reduce cardiovascular risk in primary care: a mixed design multi-center study in underserved populations

Breaking the digital gap to reduce cardiovascular risk in primary care

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