Epidemiologic and Microbiologic Characteristics of Recurrent Bacterial and Fungal Meningitis in The Netherlands, 1988–2005

Driel, Joris J. van; Bekker, Vincent; Spanjaard, Lodewijk; Ende, Arie van der; Kuijpers, Taco W.

doi:10.1086/590251

Cited by 14 publications

(14 citation statements)

References 46 publications

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“…A physiological immunodeficiency is present in young children, in whom protective antibodies are not yet produced, and the elderly, whose humoral and cellular immunity functions diminish (72,243,326). As a general rule, a recurrence of meningitis without anatomical defects warrants further investigation to detect an immunodeficiency (4, 303).…”

Section: Immunocompromised Statementioning

confidence: 99%

“…In a recent review, S. pneumoniae was found to be responsible for 57% of cases, and the majority were associated with compromised meningeal integrity (303). Recurrent meningitis due to N. meningitidis has been associated with complement deficiencies (230,303,326). H. influenzae, particularly of non-b serotypes, is the third most common causative agent and is found in patients with anatomical defects (4,326).…”

Section: Recurrent Bacterial Meningitismentioning

confidence: 99%

“…Recurrent meningitis due to N. meningitidis has been associated with complement deficiencies (230,303,326). H. influenzae, particularly of non-b serotypes, is the third most common causative agent and is found in patients with anatomical defects (4,326). Empirical antimicrobial coverage in recurrent meningitis consists of an expandedspectrum cephalosporin and vancomycin (4,320).…”

Section: Recurrent Bacterial Meningitismentioning

confidence: 99%

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Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

2010

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SUMMARY The epidemiology of bacterial meningitis has changed as a result of the widespread use of conjugate vaccines and preventive antimicrobial treatment of pregnant women. Given the significant morbidity and mortality associated with bacterial meningitis, accurate information is necessary regarding the important etiological agents and populations at risk to ascertain public health measures and ensure appropriate management. In this review, we describe the changing epidemiology of bacterial meningitis in the United States and throughout the world by reviewing the global changes in etiological agents followed by specific microorganism data on the impact of the development and widespread use of conjugate vaccines. We provide recommendations for empirical antimicrobial and adjunctive treatments for clinical subgroups and review available laboratory methods in making the etiological diagnosis of bacterial meningitis. Finally, we summarize risk factors, clinical features, and microbiological diagnostics for the specific bacteria causing this disease.

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Section: Immunocompromised Statementioning

confidence: 99%

Section: Recurrent Bacterial Meningitismentioning

confidence: 99%

Section: Recurrent Bacterial Meningitismentioning

confidence: 99%

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Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

2010

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“…Perbedaan usia dan jenis kelamin kemungkinan karena perbedaan mekanisme penyakit dan kekebalan tubuh pejamu melawan organisme penyebab. 13 Kejang pada kasus meningitis bakteri terjadi pada sepertiga kasus, 14 terutama pada kasus yang disebabkan oleh S. pneumonia, N.meningitidis, dan H. influenza. Kami mendapatkan kejang pada kelompok dengan curiga meningitis adalah 29/31, lebih tinggi dari penelitian sebelumnya kemungkinan karena kuman penyebabnya berbeda dan kejang sangat dipengaruhi oleh faktor genetik dan usia.…”

Section: Pembahasanunclassified

Bacterial Meningeal Score (BMS) Sebagai Indikator Diagnosis Meningitis Bakterialis di RSUP Dr. Sardjito Yogyakarta

Arydina

Herini

Triono

2016

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Latar belakang. Meningitis bakterialis merupakan salah satu penyebab morbiditas dan mortalitas yang penting pada anak. Anak dengan meningitis biasa datang ke rumah sakit dan mendapat antibiotik intrakranial tanpa menunggu hasil kultur. Hal ini dilakukan karena membedakan meningitis bakterialis dan meningitis bukan bakteri pada awal perjalanan penyakit terkadang sulit. Beberapa indikator dapat digunakan untuk membedakan hal itu. Salah satunya adalah bacterial meningeal score (BMS), terdiri dari pengecatan gram cairan serebrospinal positif, protein cairan serebrospinal ≥80 mg/dL, neutrofil darah tepi ≥10.000 sel/mm3, riwayat kejang, neutrofil absolut cairan serebrospinal ≥1000 sel/ mm3.Tujuan. Mengetahui apakah bacterial meningeal score merupakan indikator yang baik untuk menegakkan diagnosis meningitis bakterialis akut pada bayi dan anakMetode. Uji diagnostik pada anak usia >1 bulan-18 tahun, yang dicurigai sebagai meningitis berdasarkan kriteria WHO, mulai Februari 2011 sampai dengan April 2011. Diagnosis meningitis bakterialis ditegakkan apabila hasil kultur ditemukan bakteri.Hasil. Di antara 31 anak subjek penelitian, 16 laki-laki. Semua datang dengan demam, kejang (29/31), penurunan kesadaran (15/31), dan tanda meningeal (17/31). Pengecatan gram positif pada 9/31 sampel dan kultur positif 12/31 sampel. Hasil analisis statistik didapatkan sensitivitas BMS 83,3%, spesifisitas 89,5%, nilai praduga negatif 83,3%, nilai praduga positif 89,5%, likelihood ratio positif 7,92, dan likelihood ratio negatif 0,186. Bakteri yang tumbuh dari hasil kultur adalah P. aerogenosa, S.epidermidis and Paracoccus sp, Bacillus. Sp dan Enterococcus sp.Kesimpulan. Bacterial meningeal score merupakan indikator yang baik untuk menilai meningitis bakteri pada bayi dan anak karena memiliki sensitivitas, spesifisitas, nilai praduga negatif, nilai praduga positif, likelihood ratio positif dan likelihood ratio negatif yang tinggi.

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“…11,12 Following the success of these meningococcal vaccine programs, the majority of IMD cases in these countries are now caused by MnB. 13,14 Because the MnB capsular polysaccharide polysialic acid is also present in human neuronal tissue, vaccines based on MnB polysaccharides provide poor immunogenic responses and approaches to overcome this have failed. 15,16 An alternate approach has been the development of vaccines based on outer membrane vesicles, which have been used to combat epidemic MnB outbreaks.…”

Section: Introductionmentioning

confidence: 99%

A phase 1, randomized, open-label, active-controlled trial to assess the safety of a meningococcal serogroup B bivalent rLP2086 vaccine in healthy adults

Sheldon

Schwartz

Jiang

et al. 2012

Human Vaccines & Immunotherapeutics

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Epidemiologic and Microbiologic Characteristics of Recurrent Bacterial and Fungal Meningitis in The Netherlands, 1988–2005

Abstract: In The Netherlands, the prevalence of recurrent bacterial and fungal meningitis is low. The distribution of causative microorganisms differs between cases of recurrent meningitis and cases of nonrecurrent meningitis; this could be associated with vaccination.

Cited by 14 publications

References 46 publications

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

Epidemiology, Diagnosis, and Antimicrobial Treatment of Acute Bacterial Meningitis

Bacterial Meningeal Score (BMS) Sebagai Indikator Diagnosis Meningitis Bakterialis di RSUP Dr. Sardjito Yogyakarta

A phase 1, randomized, open-label, active-controlled trial to assess the safety of a meningococcal serogroup B bivalent rLP2086 vaccine in healthy adults

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