Epidemiologic aspects of male infertility

Velu, Arunadevi; Prasad, Geetha

doi:10.18203/2320-1770.ijrcog20173446

Cited by 9 publications

(6 citation statements)

References 16 publications

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“…[11] In an Indian epidemiological study on male infertility, the cause of infertility was pure male factor in 31.6% and the problem lay with both male and female partners in 20.4%. [12] Recent study shows that the prevalence of obesity in India ranges from 13% to 50% of urban and 8-38.2% of the rural population. [13] The paradigm shift to obesity can be attributed to sedentary lifestyle and consumption of energydense food.…”

Section: Discussionmentioning

confidence: 99%

Association between male body mass index and semen parameters

Puri¹,

Sharma²,

Gaur³

et al. 2020

IJMS

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Objective: Obesity is a modern-day epidemic. Body mass index (BMI) is an easily computed surrogate marker of obesity. The incidence of obesity has paralleled the incidence of male infertility. The evidence of the association between BMI and semen parameters stays rather inconclusive. The aim of this study was to understand the association between BMI and semen parameters of male subjects evaluated at the infertility clinic. Materials and Methods: A prospective study was conducted on 410 male subjects (>18 years of age) who were referred to clinical pathology from the infertility clinic. Semen analysis for macroscopic parameters – total sperm concentration, motility, morphology, and viability, was done as per the guidelines laid by the WHO (WHO-5th edition 2010). Results: All the semen parameters showed higher aberrations in the obese group than the normal BMI group. However, on Pearson Chi-square analysis, none of these differences were found to be statistically significant (P > 0.05). On Pearson correlation analysis, none of the parameters showed a statistically significant correlation with BMI. Conclusion: The present study did not find any statistically significant differences for the commonly measured semen parameters, among the three BMI groups. We thus conclude that increased BMI or obesity has no significant impact on the semen parameters.

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Section: Discussionmentioning

confidence: 99%

Association between male body mass index and semen parameters

Puri¹,

Sharma²,

Gaur³

et al. 2020

IJMS

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“…Globally, approximately 15% of reproductive aged couples have the problem of infertility. 1 , 2 Male infertility has been found to be a major contributing factor to the overall infertility cases in Saudi Arabia. 3 , 4 A one year retrospective study conducted on infertile couples reported a prevalence of approximately 19% male infertility cases in the eastern province region of Saudi Arabia.…”

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confidence: 99%

Effect of seminal redox status on lipid peroxidation, apoptosis and DNA fragmentation in spermatozoa of infertile Saudi males

Fatima

Alwaznah

Aljuraiban

et al. 2020

SMJ

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To assess the effect of seminal redox status on lipid peroxidation)LPO(, apoptosis and integrity of sperm DNA in infertile males. Methods: In this case-control study, the total antioxidant status)TAS(and reactive oxygen species)ROS(levels were analyzed within the seminal plasma of fertile normozoospermic, n=40 and infertile)asthenozoospermic, n=30; oligoasthenoteratozoospermic, n=30(males. Additionally, the level of 4-hydroxynonenal)4-HNE(, DNA fragmentation, and caspase-3 activity were estimated in the spermatozoa. Original Article Results: Significantly)p<0.001(increased seminal ROS level with decreased TAS scores was observed in the infertile groups compared to normozoospermics. The infertile males showed marked elevated)p<0.001(levels of 4-HNE, DNA fragmentation and caspase-3 activity compared to normozoospermics, which was positively correlated to increased seminal ROS levels and negatively to the TAS score in the studied groups. Seminal ROS level was significantly inverse correlated to the semen parameters. Additionally, a strong negative correlation between DNA fragmentation, LPO, caspase-3activity and seminal parameters were observed. Conclusion: Seminal oxidative stress is a potential risk factor for LPO, DNA damage, and apoptosis in spermatozoa, which can affect semen quality and male fertility. Thus, in addition to conventional seminological parameters, measurement of seminal oxidative stress and sperm DNA integrity may also be employed to investigate the functional integrity of spermatozoa at the molecular level.

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“…Concerning male infertility, Agarwal et al, in a systematic review, found higher rates of male infertility in Central and Eastern Europe (8-12%), Australia (8-9%) and Europe (7.5%) than North America (4.5-6%) and Sub-Saharan Africa (2.5-4.8%) [7]. Recent studies in India found a frequency of 20.4% of pure male factor in infertile couple, associated with several factors such as a history of varicocele surgery, STI, alcohol consumption, diabetes, small size testis and tobacco [8,9]. One-third of these patients had erectile dysfunction while half had azoospermia or oligospermia [8].…”

Section: Introductionmentioning

confidence: 99%

“…Recent studies in India found a frequency of 20.4% of pure male factor in infertile couple, associated with several factors such as a history of varicocele surgery, STI, alcohol consumption, diabetes, small size testis and tobacco [8,9]. One-third of these patients had erectile dysfunction while half had azoospermia or oligospermia [8]. In China, Cong et al found an increased risk of infertility in those engaged in occupations with the high-temperature working environment [10]; while tobacco (29%) and history of varicocele surgery (22%) were the main risk factors for male infertility in Iran [11].…”

Section: Introductionmentioning

confidence: 99%

Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting

Ngalle¹,

Donfack²,

Mpah³

et al. 2020

IJCU

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Background: Male infertility is defined as a lack of pregnancy for a couple after 12 months of regular and normal sexual intercourse without contraception with the cause being clearly from the male origin. Contrary to popular belief, the prevalence of male infertility is similar to that of female infertility and sometimes even higher. However, data on the subject in Cameron are scarce and nonexistent in the city of Douala. This motivated the realization of this study in two centers in the city of Douala. The objective was to describe the epidemiological profile of male infertility. Methods: We conducted a crosssectional study among patients who consulted for infertility in two hospital centers in Douala from January 2014 to October 2019. A consecutive sample of all eligible cases was considered for this study. Data were analyzed using Statistical Package for Social Sciences (SPSS Inc, Chicago, Illinois, USA) V. 20.0 and EPI-INFO V. 3.5 software. Analyzed variables included sociodemographic data (age, marital status, educational level, profession, region, alcohol, smoking habit and mean infertility duration) and other causes of infertility (obesity, history of testes infection, STI, testes traumatism, varicocele or varicocele surgery, herniorrhaphy, genetic or malformative disease). Results: We included 137 patients' records. The frequency of male infertility for patients consulting in urology was 5.6%. Their average age was 35.4±7.4 years. The average number of sexual intercourses per week was 2.7±0.97. Those patients were mainly from an intellectual profession (40.2%), married (71.5%) with a higher education level (67.2%). Almost 60% of the studied population had alcohol consumption. Primary infertility accounted for 65.7% of the study population and the average duration of infertility was 5.9±5.3 years. The main factors for infertility were respectively history of sexually transmitted infections (STI) in 59 (43.1%) and childhood mumps in 42 (32.7%) cases. Furthermore, herniorrhaphy (16.1%) and varicocelectomy (10.9%) were the most representative surgical background. Conclusion: Male infertility is not uncommon in urological consultation with primary infertility been more frequent. Risk factors of infertility in our setting included a history of STI, mumps, and surgery.

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Epidemiologic aspects of male infertility

Cited by 9 publications

References 16 publications

Association between male body mass index and semen parameters

Association between male body mass index and semen parameters

Effect of seminal redox status on lipid peroxidation, apoptosis and DNA fragmentation in spermatozoa of infertile Saudi males

Epidemiological Profile of Male Infertility in Two Hospitals of Douala: A Cross-Sectional Study in a Sub-Saharan Africa Setting

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