Epidemiologic data of biopsy-proven renal diseases: Experience from a single center in South India

Bandi, Varun Kumar; Nalamati, Ammanna; Kasinaboina, Bharathi; Chundru, Sai Swapna

doi:10.4103/1319-2442.256855

Cited by 8 publications

(14 citation statements)

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“…These results were consistent with the studies reporting indications and epidemiologic data of renal biopsies in India. [12][13][14][15] The percentage of patients with other indications was consistent with that observed in some other studies. 16,17 We observed a lower risk of major complications (2.6%).…”

Section: Urinary Bladder Clot 1 Persistent Hematuria 30 H Post-biopsy...supporting

confidence: 91%

Indications for Percutaneous Ultrasound-Guided Renal Biopsy and Complications Associated with it: An Observational Study

Bhat

Sulayman

Parry

et al. 2022

jrenhep

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Renal biopsy is performed for various reasons depending on the clinical manifestations presented. Although percutaneous kidney biopsy is a safe procedure, major or minor complications could occur. Our study aimed to assess the indications for percutaneous renal biopsy and complications associated with the procedure. This was a prospective observational study conducted in the Department of Nephrology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. Patients who underwent percutaneous ultrasound-guided renal biopsy at the institute between October 2017 and June 2019 were enrolled in the study. Data regarding indications for performing a percutaneous renal biopsy and incidence of minor and major post-biopsy complications were collected. A total of 229 patients who underwent ultrasound-guided percutaneous renal biopsy were enrolled in the study. The most common indications for ultrasound-guided percutaneous renal biopsy were nephrotic syndrome (33.3%), subnephrotic proteinuria with azotemia (14%), and unexplained azotemia with proteinuria and hematuria (13.5%). Post-biopsy complications were observed in 89 (37.55%) patients. Minor complications developed in 83 (36.22%) patients and major complications in six (2.62%) patients. Among patients with major complications, two (0.87%) patients underwent invasive procedures (embolization and cystoscopic removal of bladder clot) and four patients developed hemodynamic instability. No procedure-related mortality was reported in the study. The most common indications for renal biopsy were nephrotic syndrome, subnephrotic proteinuria with azotemia, unexplained azotemia with proteinuria, and hematuria. The incidence of major complications was low.

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Section: Urinary Bladder Clot 1 Persistent Hematuria 30 H Post-biopsy...supporting

confidence: 91%

Indications for Percutaneous Ultrasound-Guided Renal Biopsy and Complications Associated with it: An Observational Study

Bhat

Sulayman

Parry

et al. 2022

jrenhep

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“…Lupus nephritis remains the commonest secondary GN and this finding is universal throughout the world [13][14][15]. However, the number of males with lupus nephritis in our cohort is large (27%).…”

Section: Discussionmentioning

confidence: 78%

Glomerulonephritis Histopathological Pattern Change

et al. 2020

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Background Glomerulonephritides (GN) are relatively rare kidney diseases with substantial morbidity and mortality. They are often difficult to treat, sometimes with no cure, and can lead to chronic kidney disease (CKD) and end stage kidney disease (ESKD). Kidney biopsy is the diagnostic procedure of choice with variable indications from center to center. It helps in identifying the exact specific diagnosis, assessing the level of disease activity and severity, and hence aids in proper therapy and helps predicting prognosis. There is a global change of pattern of glomerular disease over the last five decades. Methods Retrospective analysis of all kidney biopsies (545 cases) that were done in patients over 12 year-old over last six years in four major hospitals in Kuwait. The indications for kidney biopsy were categorized into six clinical syndromes: nephrotic syndrome, sub-nephrotic proteinuria, nephrotic syndrome plus acute kidney injury (AKI), sub-nephrotic proteinuria plus AKI, isolated hematuria, and Unexplained renal impairment. We calculated the incidence of each type of kidney disease and indication of biopsy. Results most common indication of kidney biopsy was sub-nephrotic proteinuria associated with AKI in 179 cases (32.8%). Primary Glomerulonephritis was the main diagnosis that was reported in 356 cases (65.3%). Immunoglobulin A Nephropathy (IgAN) was the commonest lesion in primary glomerulonephritis in 85 (23.9%) cases. Secondary Glomerulonephritis was diagnosed in 134 cases (24.6%), 56 (41.8%) of them were reported as lupus nephritis cases. In young adults (below 18 years of age) there were 31 cases reviews, 35.5% were found to have minimal change disease (MCD). Conclusion IgAN is the commonest glomerulonephritis in primary nephrotic syndromes in Kuwait over the past six years. Lupus nephritis is the leading secondary glomerulonephritis diagnosis.

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“…Nephrotic syndrome was a prevalent clinical presentation and indicated renal biopsy mainly in primary forms but also in some secondary glomerulopathies. Studies have shown a higher frequency of nephrotic syndrome in different glomerulopathies, mainly MCD, FSGS and MN [ 2 , 6 , 12 , 21 , 22 ], which has also been described in systematic reviews [ 17 ], and is mainly a clinical presentation of primary glomerulopathies [ 16 , 18 ]. For patients with IgAN, nephritic syndrome and proteinuria/haematuria prevailed, which is in agreement with the data presented in other studies [ 6 , 18 , 19 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have shown a higher frequency of nephrotic syndrome in different glomerulopathies, mainly MCD, FSGS and MN [ 2 , 6 , 12 , 21 , 22 ], which has also been described in systematic reviews [ 17 ], and is mainly a clinical presentation of primary glomerulopathies [ 16 , 18 ]. For patients with IgAN, nephritic syndrome and proteinuria/haematuria prevailed, which is in agreement with the data presented in other studies [ 6 , 18 , 19 , 21 ]. In secondary glomerulopathies, nephrotic syndrome and proteinuria/haematuria were prevalent in patients with LN, nephrotic syndrome in patients with DKD, nephrotic syndrome and proteinuria with loss of renal function in patients with 2nd FSGS and monoclonal gammopathies, and nephritic syndrome in patients with systemic vasculitis.…”

Section: Discussionmentioning

confidence: 99%

“…Temporal variation has been observed in the incidence rate of both primary and secondary glomerular diseases. Studies that evaluated the disease incidence over two or more decades showed an increasing trend in the prevalence of FSGS [ 7 , 16 , 20 ], MCD [ 8 , 21 ], DKD [ 7 , 15 ], pauci-immune systemic vasculitis [ 6 , 7 ] and LN [ 6 ] as well as a temporal trend in the prevalence of IgAN [ 6 , 9 , 19 , 20 ] and membranous nephropathy (MN) [ 8 , 20 ]. Differences related to ethnicity have been reported, with IgAN [ 8 , 18 ] being more prevalent in the Asian population, FSGS being more common in populations of African descent, and MN being more prevalent in the Caucasian population [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

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The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

et al. 2021

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Background The prevalence and distribution of glomerular diseases differ among countries, and the indication to perform a kidney biopsy varies among centres. In this study, we assessed the prevalence of primary and secondary glomerulopathies based on histological diagnoses, and the correlation between glomerulopathies and demographic and clinical data was evaluated. Methods In this study, 1051 kidney biopsies were retrospectively reviewed between 2000 and 2018. Patient demographic, clinical and laboratory data were assessed. The prevalence of primary glomerulonephritis (PG) and secondary glomerulopathies (SG), as well as tubulointerstitial diseases (TIDs), hereditary nephropathies (HNs) and other diagnoses, were determined. The frequency of primary and secondary glomerulopathies was evaluated by age group, and the temporal variation in frequencies across three time periods (2000-2005, 2006-2011, and 2012-2018) was reported. Results The prevalence of SG predominated (52.4%), followed by PG (29.6%), other diagnoses (10.7%), TID (6.6%) and HN (1.1%). Among the primary forms of glomerular disease, focal segmental glomerulosclerosis (FSGS) was the most common (37.3%), followed by IgA nephropathy (IgAN, 24.4%), membranous nephropathy (MN, 18.6%) and minimal change disease (MCD, 8.4%). Lupus nephritis (LN, 41.1%) was most common in patients with SG, followed by diabetic kidney disease (DKD, 17.8%), systemic vasculitis (SV, 10.2%) and secondary FSGS (2nd FSGS, 10%). Nephrotic syndrome was the most common clinical presentation in patients with PG and also in patients with DRD and 2nd FSGS, whereas in patients with IgAN and SV, nephritic syndrome was the main presentation. For the age group between 18 and 50 years, LN, FSGS and IgAN predominated; for patients aged between 51 and 65 years, the proportion of DKD and 2nd FSGS increased, and SV was more common in patients > 65 years. The temporal variation in PG across the three time periods showed a statistically significant increase in IgAN (p = 0.001) and a reduction in FSGS over time (p < 0.001). In SG, there was a reduction in LN (p = 0.027) and an increase in DKD (p < 0.001) over time, with a tendency for 2nd FSGS to decrease over time (p = 0.053). Conclusions In the studied kidney biopsy registry, FSGS and IgAN were the most prevalent diagnoses in patients with PG, and LN and DKD were the most prevalent in patients with SG. Nephrotic syndrome was the major indication for biopsy. When comparing the temporal variation in glomerulopathies, there was a reduction in FSGS and an increase in IgAN in patients with PGs over time, and for patients with SGs, there was a reduction in LN with an increase in cases of DKD over time.

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Epidemiologic data of biopsy-proven renal diseases: Experience from a single center in South India

Cited by 8 publications

References 1 publication

Indications for Percutaneous Ultrasound-Guided Renal Biopsy and Complications Associated with it: An Observational Study

Indications for Percutaneous Ultrasound-Guided Renal Biopsy and Complications Associated with it: An Observational Study

Glomerulonephritis Histopathological Pattern Change

The spectrum of biopsy-proven glomerular diseases in a tertiary Hospital in Southern Brazil

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