Epidemiologic Study on Kawasaki Disease in Beijing From 2000 Through 2004

Du, Zhenhong; Zhao, Debin; Du, Junyan; Zhang, Yonglan; Lin, Yang; Liu, Chong; Zhang, Tuohong

doi:10.1097/01.inf.0000261196.79223.18

Cited by 100 publications

(77 citation statements)

References 7 publications

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“…The incidence of CAL was reported to be 40.2% in the present survey during the acute stage, which was comparable with the rates reported by Baer et al (22) and Zhang et al (5). However, the rate reported in the present study was relatively high when compared with that of certain other reports (9,11,13,16,23), which may be due to the delayed diagnosis and treatment as a result of the relatively lower economic level of the Inner Mongolia region. In addition, this inconsistency in CAL incidence may be due to differences in ethnicity and region, as well as discrepancy brought by multifarious diagnostic standards.…”

Section: Discussioncontrasting

confidence: 47%

Epidemiologic survey of Kawasaki disease in Inner Mongolia, China, between 2001 and 2013

Zhang

Liang

Feng

et al. 2016

Experimental and Therapeutic Medicine

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Section: Discussioncontrasting

confidence: 47%

Epidemiologic survey of Kawasaki disease in Inner Mongolia, China, between 2001 and 2013

Zhang

Liang

Feng

et al. 2016

Experimental and Therapeutic Medicine

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“…First, as mentioned earlier, KD is over-represented among Asian and Asian-American populations. [6][7][8][9][10][11]18 The fact that Japanese ancestries in Hawaii have higher incidence of KD than other ethnic groups and the same level of incidence as Japanese living in Japan confirms the ethnic genetic difference in susceptibility to KD. Second, KD shows familial aggregation.…”

Section: Epidemiological Findings Indicating Genetic Predisposition Fmentioning

confidence: 89%

Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine

Hata

Onouchi

2009

J Hum Genet

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Kawasaki disease (KD) is an acute systemic vasculitis syndrome, which primarily affects in children under the age of 5 years. In 20-25% of cases, if untreated, coronary artery lesions develop, making KD the leading cause of acquired heart disease in children in both Japan and the United States. Since 1970, 19 nationwide surveys of KD in Japan have been conducted every 2 years and the data are stored in a database. Even though the etiology of KD remains unknown, despite enthusiastic research spanning more than 40 years, we have learnt a great deal about KD from this enormous database. These 19 epidemiologic studies indicate a strong genetic influence on the disease susceptibility, prompting us and other researchers to identify the responsible genes for KD by applying either the candidate gene approach or the genome-wide approach. We have employed a genome-wide linkage study using affected sibling pair data of KD in Japan and have identified several susceptibility loci. Further analysis focusing on a region of chromosome 19, where one of the linked loci was detected, identified a predisposing gene, which codes inositol 1,4,5-trisphosphate 3-kinase C (ITPKC). In this review, we summarize the cumulative knowledge regarding KD, and then outline our hypothesis of the role ITPKC plays in KD susceptibility and our trial that aims toward the implementation of personalized medicine for KD.

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“…However, efforts to identify an infectious agent with conventional bacterial and viral cultures or serological methods, as well as with animal inoculation, have failed [4,5]. It may be that KD results from an immunologic response that is triggered by any of several different and yet unidentified microbial agents [6,7,8,9]. …”

Section: Introductionmentioning

confidence: 99%

Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers

Hassidim

Merdler²,

Chorin

et al. 2016

Int Arch Allergy Immunol

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Background: Kawasaki disease (KD) is an acute, systemic vasculitis in children, with an etiology that is not completely understood. It is assumed that the development of KD is mediated by an immunologic response. Several reports from East Asia have found a higher prevalence of atopic diseases among patients with KD, but a large-scale study of a non-Asian population regarding this correlation is still lacking. The purpose of this article was to achieve this goal. Methods: We conducted a cross-sectional, large-scale study to estimate the correlation of KD with allergic diseases. The medical history of 1,187,757 Israeli teenagers (aged 16-20 years during the years 1998-2013) was retrieved. The study population was divided into 3 groups according to a past history of noncomplicated and complicated KD and a control group. The prevalence of allergic diseases among these groups was further investigated. Results: The prevalence of atopic diseases in the 3 study groups was presented (asthma in 11.4, 8.1 and 3.5%, respectively; angioedema/urticaria in 7.1, 0 and 0.46%, respectively; allergic rhinitis in 20, 12.1 and 6.7%, respectively). In noncomplicated KD, a statistically significant link to asthma [odds ratio (OR) 2.4; p = 0.048] and a borderline significant link to allergic rhinitis (OR 1.9; p = 0.06) were found. In KD complicated with cardiac disease, statistically significant links were found for all the allergic conditions, asthma (OR 3.5; p = 0.003), allergic rhinitis (OR 3.5; p < 0.001) and angioedema/urticaria (OR 16.48; p < 0.001). Conclusion: KD is associated with allergic diseases. This association increases with the severity of the disease.

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Epidemiologic Study on Kawasaki Disease in Beijing From 2000 Through 2004

Cited by 100 publications

References 7 publications

Epidemiologic survey of Kawasaki disease in Inner Mongolia, China, between 2001 and 2013

Epidemiologic survey of Kawasaki disease in Inner Mongolia, China, between 2001 and 2013

Susceptibility genes for Kawasaki disease: toward implementation of personalized medicine

Atopic Predilection among Kawasaki Disease Patients: A Cross-Sectional Study of 1,187,757 Teenagers

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