Epidemiologic study on the origin of cancer after kidney transplantation

Abstract

The authors' results suggest that donor transmission of solid cancer is an unlikely event in their population.

Quality and Safety in the Italian Donor Evaluation Process

“…However, preliminary results from molecular biology studies show that cancer transmission from a clinically healthy donor is very rare (18). Transplants of organs deriving from donors with active cancer or history of neoplasia do not seem to pose a risk of cancer transmission to organ recipients.…”

Autotransplantation of cryopreserved ovarian tissue: a procedure with promise, risks, and a need for a registry

“…The cancers at highest risk of being transmitted to recipients include central nervous system tumors, choriocarcinoma, breast cancer, renal carcinoma, and lung cancers (94)(95)(96)(97)(98)(99)(100). The overall risk of death from a donor-derived malignancy is well less than 1% (101,102). Organ transplant recipients who are likely to die without their transplants will accept a certain level of risk due to the gravity of their situation.…”

Renal Cancer in Recipients of Kidney Transplant

“…The most common type of RCC was clear cell carcinoma (27%, n=9) 7,10,12-14,20,21,31 while the other types were: sarcomatoid (15%, n=5), 2,8 angiosarcoma (6%, n=2), 18 renal papillary tumor (6%, n=2), 28,31 anaplastic (6%, n=2), 25,29 chromophobe (3%, n=1), 16 cystic adenocarcinoma (3%, n=1), 31 anaplastic adenocarcinoma (3%, n=1), 29 giant and spindle cell carcinoma (3%, n=1), 15 and undifferentiated (6%, n=2). 17,22 The type of renal cell carcinoma was not mentioned in the rest (22%, n=7), 2,6,19,31 Other tumors (31%, n=15) comprised 31% of the cases which included: undifferentiated cancer (20%, n=3), 6 invasive urothelial carcinoma (7%, n=1), 24 papillary transitional cell carcinoma of bladder (7%, n=1). 31 Thirty-three percent of the tumors were subsequently found to be benign and the type of cancer was not mentioned in the rest (33%, n=5).…”

“…17,22 The type of renal cell carcinoma was not mentioned in the rest (22%, n=7), 2,6,19,31 Other tumors (31%, n=15) comprised 31% of the cases which included: undifferentiated cancer (20%, n=3), 6 invasive urothelial carcinoma (7%, n=1), 24 papillary transitional cell carcinoma of bladder (7%, n=1). 31 Thirty-three percent of the tumors were subsequently found to be benign and the type of cancer was not mentioned in the rest (33%, n=5).…”