Epidemiological Activity of Hemorrhagic Fever with Renal Syndrome Foci in the Territory  of the Russian Federation in 2013–2017 and Forecast for 2018

Иванова, Александра; Попов, Н. В.; Пакскина, Н. Д.; Кузнецов, А. А.; Matrosov, A. N.; Shilov, M. M.; Мочалкин, П. А.; Корнеев, М. Г.; Toporkov, V. P.

doi:10.21055/0370-1069-2018-1-16-21

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…In the European part of Russia, PUUV is identified as the leading cause of HFRS. The majority of HFRS cases are diagnosed in the Volga Federal District, which includes the Republic of Tatarstan (RT) [11]. Seven hundred and seventy-eight cases were reported in the RT in the first 10 months of 2019 [12].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of the Puumala orthohantavirus Strains in the Pre-Kama Area of the Republic of Tatarstan, Russia

et al. 2020

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Puumala orthohantavirus (PUUV) causes nephropathia epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) commonly diagnosed in Europe. The majority of HFRS cases in the European part of Russia are diagnosed in the Volga Federal District, which includes the Republic of Tatarstan (RT). The current study aims to analyze the genetic variability of PUUV in Pre-Kama region of the RT bounded by the Volga, Kama, and Vyatka rivers. In 2017, bank voles were caught in seven isolated forest traps in the Pre-Kama region and for the 26 PUUV-positive samples, the partial small (S), medium (M), and large (L) genome segment sequences were obtained and analyzed. It was determined that all identified PUUV strains belong to the Russian (RUS) genetic lineage; however, the genetic distance between strains is not directly correlated with the geographical distance between bank vole populations. One of the identified strains has S and L segments produced from one parental strain, while the M segment was supplied by another, suggesting that this strain could be the reassortant. We suggest that the revealed pattern of the PUUV strains distribution could be the result of a series of successive multidirectional migratory flows of the bank voles to the Pre-Kama region in the postglacial period.

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Section: Introductionmentioning

confidence: 99%

Prevalence of the Puumala orthohantavirus Strains in the Pre-Kama Area of the Republic of Tatarstan, Russia

et al. 2020

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“…Phylogenetic analysis of PUUV identified in NE cases from the RT and the RM. The RT and the RM are part of the Volga Federal District, which is endemic for NE ( Figure 1 ) [ 3 , 4 , 5 , 6 ].…”

Section: Resultsmentioning

confidence: 99%

“…HFRS is typically characterized by fever, increased vascular permeability, thrombocytopenia, and acute kidney injury, and currently it has the highest incidence rate of all zoonotic virus infections reported in Russia [ 1 , 2 ]. Nephropathia Epidemica (NE) is a mild form of HFRS that is endemic in the Volga Federal District of Russia, that includes the Republic of Tatarstan (RT) and the Republic of Mordovia (RM) [ 3 , 4 , 5 , 6 ]. Mortality rate is low (0–0.4%) and complete recovery of kidney function without development of chronic renal disease or acute kidney injury (AKI) is commonly expected [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia

et al. 2021

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Nephropathia Epidemica (NE), endemic to several Volga regions of Russia, including the Republic of Tatarstan (RT) and the Republic of Mordovia (RM), is a mild form of hemorrhagic fever with renal syndrome caused by infection with rodent-borne orthohantaviruses. Although NE cases have been reported for decades, little is known about the hantavirus strains associated with human infection in these regions. There is also limited understanding of the pathogenesis of NE in the RT and the RM. To address these knowledge gaps, we conducted comparative analyses of patients with NE in the RT and the RM. Clinical symptoms were more severe in patients with NE from the RM with longer observed duration of fever symptoms and hospitalization. Analysis of patient sera showed changes in the levels of numerous cytokines, chemokines, and matrix metalloproteases (MMPs) in patients with NE from both the RT and the RM, suggesting leukocyte activation, extracellular matrix degradation, and leukocyte chemotaxis. Interestingly, levels of several cytokines were distinctly different between patients NE from the RT when compared with those from the RM. These differences were not related to the genetic variation of orthohantaviruses circulating in those regions, as sequence analysis showed that Puumala virus (PUUV) was the causative agent of NE in these regions. Additionally, only the “Russia” (RUS) genetic lineage of PUUV was detected in the serum samples of patients with NE from both the RT and the RM. We therefore conclude that differences in serum cytokine, chemokine, and MMP levels between the RT and the RM are related to environmental factors and lifestyle differences that influence individual immune responses to orthohantavirus infection.

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Epidemiological Activity of Hemorrhagic Fever with Renal Syndrome Foci in the Territory of the Russian Federation in 2013–2017 and Forecast for 2018

Cited by 2 publications

References 3 publications

Prevalence of the Puumala orthohantavirus Strains in the Pre-Kama Area of the Republic of Tatarstan, Russia

Prevalence of the Puumala orthohantavirus Strains in the Pre-Kama Area of the Republic of Tatarstan, Russia

Cytokine, Chemokine, and Metalloprotease Activation in the Serum of Patients with Nephropathia Epidemica from the Republic of Tatarstan and the Republic of Mordovia, Russia

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