Epidemiological aspects of respiratory mycotic infections

Pappagianis, Demosthenes

doi:10.1128/br.31.1.25-34.1967

Cited by 18 publications

(3 citation statements)

References 67 publications

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“…Coccidioidomycosis is a pulmonary disease common in arid regions of the western hemisphere. The prevalence of infection in the population frequently exceeds 50% (5) and approximately one-half of those infected develop symptomatic disease (11). Definitive diagnosis is established by isolating the fungus, Coccidioides immitis,or by visualization of characteristic endosporulating spherules in pathological specimens.…”

mentioning

confidence: 99%

Rapid in vitro conversion and identification of Coccidioides immitis

Sun¹,

Huppert²,

Vukovich³

1976

J Clin Microbiol

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Since many contaminating nonpathogenic fungi resemble Coccidioides immitis culturally, isolates from patients must be inoculated into laboratory animals to confirem identification as C. immitis. This procedure is time-consuming, expensive, and not generally available in clinical laboratories. When cultures of C. immitis were grown in slide cultures on modified Converse liquid medium in purified agar and incubated at 40 C in a candle jar, all 57 isolates demonstrated inhibition of mycelial growth and conversion of arthrospores to endosporulating spherules in 3 to 5 days. Representative isolates of six species of nonpathogenic fungi that resembled C. immitis culturally either did not grow or failed to produce endosporulating spherules under the same conditions. This procedure is recommended for confirming the identication of a culture as C. immitis.

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mentioning

confidence: 99%

Rapid in vitro conversion and identification of Coccidioides immitis

Sun¹,

Huppert²,

Vukovich³

1976

J Clin Microbiol

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“…Overall, only about 5% of those infected with Coccidioides require long-term management [ 19 ]. Clinically apparent second infections are extremely rare [ 20 ] and recrudescence of infection, once controlled, is infrequent. However, the fungus remains viable in the host for many years [ 21 ], possibly for life.…”

Section: Coccidioidal Life Cycle and Immunitymentioning

confidence: 99%

Challenges to Implementing a Vaccine for Coccidioidomycosis

Barker,

Thompson,

Ampel

2024

Open Forum Infectious Diseases

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“…Persistent skin reactivity was observed in people who recovered from primary coccidioidomycosis, which suggested that previous exposure to this fungus led to cellular immunity protection ( Catanzaro et al 1975 ). Early studies with this strain were seminal for correlating persistent protection to subsequent fungal exposure, and to the presence of viable Coccidioides cells in granulomas ( Pappagianis et al 1965 ; Pappagianis 1967 ). This strain was also used to demonstrate that hypersensitivity to coccidioidin in mice is mediated by cellular immunity and predicts protection against further infection ( Cox et al 1988 ).…”

Section: Introductionmentioning

confidence: 99%

A chromosomal-level reference genome of the widely utilized Coccidioides posadasii laboratory strain “Silveira”

Teixeira

Stajich

Sahl

et al. 2022

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Coccidioidomycosis is a common fungal disease that is endemic to arid and semi-arid regions of both American continents. Coccidioides immitis and C. posadasii are the etiological agents of the disease, also known as Valley Fever. For several decades, the C. posadasii strain Silveira has been used widely in vaccine studies, is the source strain for production of diagnostic antigens, and is a widely used experimental strain for functional studies. In 2009, the genome was sequenced using Sanger sequencing technology, and a draft assembly and annotation was made available. In the current study, the genome of the Silveira strain was sequenced using Single Molecule Real Time Sequencing (SMRT) PacBio technology, assembled into chromosomal-level contigs, genotyped, and the genome was reannotated using sophisticated and curated in silico tools. This high-quality genome sequencing effort has improved our understanding of chromosomal structure, gene set annotation, and lays the groundwork for identification of structural variants (e.g., transversions, translocations, and copy number variants), assessment of gene gain and loss, and comparison of transposable elements in future phylogenetic and population genomics studies.

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Epidemiological aspects of respiratory mycotic infections

Cited by 18 publications

References 67 publications

Rapid in vitro conversion and identification of Coccidioides immitis

Rapid in vitro conversion and identification of Coccidioides immitis

Challenges to Implementing a Vaccine for Coccidioidomycosis

A chromosomal-level reference genome of the widely utilized Coccidioides posadasii laboratory strain “Silveira”

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