This work aimed to evaluete the acute toxicity and to compare the analgesic and antipyretic effects of a recipe consisting
of a mixture of leaf powders from of S. alata, and J.curcas with these two plants. Acute toxicity was evalueted by oral
administration of a single dose (5000 mg/kg) orally in mice according the OECD, (2001) guideline no. 423. The results obtained show that the
aqueous extracts of the leaves of S. alata, J.curcas and the recipe caused a brief reduction of mobility. However, no mortality and change in
general behavior were observed. Pain was induced by intraperitoneal administration of 0.6% acetic acid in mice and by 2.5% subplantar
formaldehyde in rats. The results obtained show that paracetamol (standard drug, 100 mg/kg), tramadol (standard drug, 10 mg/kg), aqueous
extracts of S. alata (250, 500 and 1000 mg/kg), J. curcas ( 250, 500 and 1000 mg/kg) and the recipe (250, 500 and 1000 mg/kg) signicantly
reduced (P<0.001) the number of abdominal writhing induced by acetic acid as well as the frequency of licking or biting of the paws induced by
formaldehyde during the two phases compared to the control group. These results suggest a peripheral and central analgesic effect of the aqueous
extracts with a potentiation of the effect by the recipe. Fever was induced by subcutaneous administration of a solution of brewer's yeast
(Saccharomyces cerevisiae). The results obtained show that the aqueous extracts of S. alata (250, 500 and 1000 mg/kg), J. curcas (1000 mg/kg)
and the recipe (250, 500 and 1000 mg/kg) signicantly lower (p<0.05) the hyperthermia induced by brewers' yeast with more marked falls
obtained with the receipt between 4 and 5 hours.