Epidemiological factors and survival experience in 1770 children with acute leukemia treated by members of children's study group a between 1957 and 1964

Abstract

In a group of 1770 children with acute leukemia, treated in 11 pediatric centers associated with Children's Cancer Group A, surgical data was related to age at diagnosis, morphological type, the leukocyte count at onset, and the year of diagnosis. The age distribution was different in the 3 morphological types of childhood leukemia. A peak at the age 2 to 3 years, with a broad base extending from 2 to 5 years, was characteristic of acute lymphoid leukemia, while the peak was absent in other morphological types. The age distribution was similar in Caucasian and Negro children. The most favorable prognosis was found in children with acute lymphoid leukemia who were 2 to 6 years of age at diagnosis in whom the leukocyte counts were below 4,000/mm3 at onset. Progress in extending the median survival time of all children with acute lymphoid but not other types of leukemia was noted between 1957 and 1964. The 10% survival figure improved for all types of leukemia during this period.

Acute nonlymphocytic leukemia in 171 children

“…(3) Features associated with statistically significant differences in survival include the shorter survival of patients with platelet counts below 10,000/mm3 , and the longer survival of patients with initial leukocyte counts below 10,000/mm3, platelet counts of 100,000/mm3 or above, or no palpable hepatomegaly. A similar inverse relationship of prognosis and mass or extent of leukemia has been found in ALL (7,10,17,25,64).…”

“…Some reports specify 2 subtypes of ANLL, myelocytic and monocytic, in ratios of 1 : 1-10: 1. If we apply the same division in this series by grouping AML, APML, and AEL as myelocytic and AMML, AMoL, and AHL as monocytic, the ratio is 1.4: 1, the same as reported by AEL represented 2% of children with ANLL in this series compared to 4% (7), 3% (15), and 2% (8) in other series. The proportion of subtypes of ANLL in adults and children has been found to be similar (6,14,15).…”

“…Age this series, confirming the observations of others (6,10,14,15). In 2 series (7,8) ANLL made up a greater proportion of acute leukemia under 1 year of age, and although no distinct peak was observed, the incidence of ANLL was slightly greater in the first 5 years of life than in the 3 subsequent 5-year periods (6)(7)(8). In adult ANLL the number of cases increases after age 40 reaching a peak in the 60-70-year age group (6).…”

“…Young and Miller (1) found 8% black children with both ALL and ANLL. In 2 large series the percentage of black children with acute leukemia was 3.7% (7) and less than 1% (8). The larger proportion of blacks in this study probably reflects a greater population in the referral area.…”

Acute leukemia in malaysian children

“…: prognostic features and the 15 cases with I "poor" prognostic features is shown in 8 Of those who died there is one who survived 3 54 months, a patient who had already relapsed on treatment prior to admission to our unit.…”