Epidemiological, molecular, and clinical features of rotavirus infections among pediatrics in Qatar

Mathew, Shilu; Ansari, Khalid Al; Thani, Asmaa A. Al; Zaraket, Hassan; Yassine, Hadi M.

doi:10.1007/s10096-020-04108-y

Cited by 12 publications

(17 citation statements)

References 80 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Phylogenetic analyses of the HRVA detected in this study lay entirely within the G2 lineage. However, as reported by several studies in Saudi Arabia 22 , 23 , 40 , Lebanon 21 , Bahrain 41 , Kuwait 42 , and Oman 43 , the predominant lineage of HRVA was G1, whereas G3 was the most prevalent genotype in Qatar 19 . A recent study highlighted a surge in G2 incidence in Saudi Arabia, particularly the G2P[4] genotype, occurring after vaccination, which may partially justify our results 39 .…”

Section: Discussionmentioning

confidence: 68%

“…In addition, several G and P type combinations have been detected as their corresponding genes were discretely passed to progeny viruses via reassortment. So far, 36 G and 51 P types demonstrate intratypic variation 19 . The G1, G2, and G9 and the P 1 , P 4 , and P 8 genotypes have been frequently recorded at high prevalence in Saudi Arabia and its surrounding countries 20 – 23 .…”

Section: Introductionmentioning

confidence: 97%

“…The G1, G2, and G9 and the P 1 , P 4 , and P 8 genotypes have been frequently recorded at high prevalence in Saudi Arabia and its surrounding countries 20 – 23 . Moreover, fluctuations in rotavirus G-P type combinations are influenced by seasonal variations and geographical locations 19 . Interestingly, VP7 protein molecules exists on virion surface in larger concentrations of about 6.5 times than that of VP4 24 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Novel insights of waterborne human rotavirus A in Riyadh (Saudi Arabia) involving G2 predominance and emergence of a thermotolerant sequence

Nour

Hanif

Alanazi

et al. 2021

Sci Rep

View full text Add to dashboard Cite

The routine evaluation of water environments is necessary to manage enteric virus-mediated fecal contamination and the possible emergence of novel variants. Here, we detected human rotavirus A (HRVA) circulating in two wastewater treatment plants, two lakes, irrigation water and a wastewater landfill located in Riyadh. VP7-derived surface protein sequences were assessed by phylogenetic analyses and inspection of thermotolerance-mediated secondary structure and seasonal variation. HRVA was most prevalent at An-Nazim wastewater landfill (AN-WWLF; 63.89%). Phylogenetic analyzes revealed the predominance of HRVA G2 lineage for the first time in Saudi Arabia. Moreover, a single HRVA sequence (2B64I-ANLF3/2018) was recovered at 45 °C from AN-WWLF; secondary structure prediction indicated that this sequence was thermotolerant with a high hydrophobicity, an absence of Ramachandran outliers, and a higher content of proline patches on the protein surface. Varied relationships were significantly observed between sampling areas influenced by temperature ranges (p < 0.05). HRVA prevalence was influenced by seasonal variations, favoring moderate temperatures in late autumn and early winter in all locations. However, a significant temperature impact was detected in Wadi-Hanifah Lake (p = 0.01). Our study extends the knowledge of currently circulating HRVA genotypes, and indicates the probable emergence of thermotolerant strains and seasonally mediated HRVA prevalence.

show abstract

Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel insights of waterborne human rotavirus A in Riyadh (Saudi Arabia) involving G2 predominance and emergence of a thermotolerant sequence

Nour

Hanif

Alanazi

et al. 2021

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Diouf., et al in Senegal in its study on malnutrition and acute diarrhea declared that the predominance of candida albicans was nuanced by the massive use of antibiotics, which caused disturbances of the intestinal flora [14,15]. We have not documented cases of listeria monocytogene associated with childhood diarrhea in pediatric settings; in the literature, they are responsible for gastroenteritis in the event of a large inoculum [13]. According to the WHO, E. coli, Salmonella, shigella, campylobacter jejuni and cryptospridium are responsible for bacterial diarrhea in children in developing countries [15].…”

Section: Discussionmentioning

confidence: 83%

Diarrhea of Bacterial and Parasitic Origin in Children in the Pediatric Department of the ANAIM Hospital in Kamsar Guinea

Ibrahima¹,

Binta²,

Mustapha³

et al. 2023

Act Scie Medic

View full text Add to dashboard Cite

IntroductionDiarrhea in children is a major problem and a major threat to public health, it is considered the second leading cause of infant mortality in the world [1,2]. Nearly 1.7 billion cases occur each year, half of them in Africa and South Asia. It kills approximately 525,000 children under the age of five every year [1,2]. It accounts for 40.0% of global under-five mortality [3,4]. Bacterial pathogens contribute enormously to the disease, being responsible for 38.0% of deaths from childhood diarrhea [3]. Developing countries bear the heaviest burden, causing 10.0% of deaths in Nigeria, IndiaIntroduction: Diarrhea is one of the leading causes of illness and death in children under 5 years of age in developing countries. The etiologies are varied and depend on the living conditions. The aim of our study was to describe the causative germs by performing stool culture and examination of stool, in order to help set up a targeted intervention and provide an early warning for more effective response measures.Method: This was a prospective cross-sectional study of descriptive type, conducted over a 12-month period from January 1 to December 31, 2018 in the pediatric department of ANAIM Hospital in Kamsar. We included all children hospitalized for acute diarrhea and who had undergone coproculture and stool parasitology before any treatment.Results: Out of a total of 1223 admissions, 293 cases of acute diarrhea were hospitalized in the pediatric ward of Kamsar, the average age was 22±8 months, the associated pathologies were malaria (86.60%), severe acute malnutrition (11.95%), acute otitis (9.55%).The bacteria found were E. coli (1.71%), Klebsiella (1.02 %,), Salmonella (0.34%), shygella (0.34%) and listeria monocytogene (0.34).The intestinal parasites found were amoebae (3.75%), giardia (3.75%), roundworms (0.34%) and trichomonas (0.34%). Conclusion:Diarrhea is an important cause of morbidity in children in the pediatric department of the hospital of Kamsar. The germs found were dominated by E. coli, Klebsiella, amoebae and giardia.

show abstract

“…3 Similarly a study in Qatar reported lower G9P[4] frequency in summer. 35 However, a study in Egypt did not find a significant association between RVA genotype distribution and different seasons. 39…”

Section: Discussionmentioning

confidence: 94%

Multicenter Study of Rotavirus Infection, Diversity of Circulating Genotypes and Clinical Outcomes in Children ≤5 Years Old in Iran

Mansour Ghanaiee,

Fallah,

Karimi

et al. 2023

Pediatric Infectious Disease Journal

View full text Add to dashboard Cite

Background: To determine the epidemiology of rotavirus group A (RVA) infection in symptomatic children, and analyze genotype diversity in association with clinical characteristics, geographical and seasonal changes. Methods: The stool samples of symptomatic children 5≥ years old were collected from 5 different hospitals during December 2020 and March 2022. Rotavirus stool antigen test was done and G and P genotypes of the positive samples were determined. Associations of the infection and genotype diversity with demographical and clinical data were assessed by statistical methods. Results: RVA infection was detected in 32.1% (300/934) of the patients (Ranges between 28.4% and 47.4%). An inverse association with age was detected, where the highest frequency was measured in children ≤12 months of age (175/482, 36.3%). The infection was more frequent during winter (124/284, 43.7%) and spring (64/187, 34.2%). Children who were exclusively fed with breast milk showed a lower rate of infection (72/251, 28.6%). Among the 46 characterized genotypes (17 single- and 29 mixed-genotype infections), G1P[8] and G9P[4] were more frequently detected in children <36 (67/234, 28.63%) and 36–60 (7/24, 29.16%) months of age children, respectively. A seasonal diversity in the circulating genotypes was detected in different cities. Children with G1P[8], G1P[6], and mixed-genotype infection experienced a shorter duration of hospitalization, and a higher frequency of nausea and severe diarrhea, respectively. Conclusions: In this study high frequency of RVA infection was detected in symptomatic children in Iran. Moreover, genotype diversity according to geographic area, seasons, age groups, and clinical features of disease was detected.

show abstract

Epidemiological, molecular, and clinical features of rotavirus infections among pediatrics in Qatar

Cited by 12 publications

References 80 publications

Novel insights of waterborne human rotavirus A in Riyadh (Saudi Arabia) involving G2 predominance and emergence of a thermotolerant sequence

Novel insights of waterborne human rotavirus A in Riyadh (Saudi Arabia) involving G2 predominance and emergence of a thermotolerant sequence

Diarrhea of Bacterial and Parasitic Origin in Children in the Pediatric Department of the ANAIM Hospital in Kamsar Guinea

Multicenter Study of Rotavirus Infection, Diversity of Circulating Genotypes and Clinical Outcomes in Children ≤5 Years Old in Iran

Contact Info

Product

Resources

About