Epidemiological risks and lessons from the first wave of new coronavirus infection (COVID-19) in medical organizations

Sisin, E. I.; Голубкова, А. А.; Козлова, И. И.; Остапенко, Н. А.

doi:10.17816/eid54401

Cited by 6 publications

(4 citation statements)

References 9 publications

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“…В ряде исследований показано, что ведущими факторами риска заражения коронавирусной инфекцией у МР в процессе выполнения ими профессиональных обязанностей были контакт с заболевшими, его теснота и продолжительность, работа с биоматериалом больных, недостаточная обеспеченность и дефекты применения средств индивидуальной зашиты, отсутствие качественного инструктажа перед работой с пациентами, инфицированными SARS-CoV-2, и т.д. При этом в данной профессиональной группе частота развития клинических форм с поражением легочной ткани не отличалась от таковой у совокупного населения [11][12][13].…”

Section: технологии полногеномного секвенирования Sars-cov-2 для опре...unclassified

The risk of developing severe clinical forms of covid-19 in healthcare workers in the initial period of the pandemic: Non-occupational factors and laboratory prognostic indicators

Platonova¹,

Голубкова²,

Sklyar³

et al. 2023

Health Risk Analysis

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Under the COVID-19 pandemic, healthcare workers were at the highest risk of getting infected with the disease; this necessitates specialized studies in this occupational group. The aim of the study was to identify non-occupational risk factors and laboratory markers indicating that severe clinical forms of new coronavirus infection would probably develop in healthcare workers in the initial period of the pandemic. The study included 366 workers who suffered COVID-19 in 2020–2021. The disease was confirmed by examining smears from the pharynx and nose with PCR. Some of the samples were examined using the SARS-CoV-2 whole genome sequencing technology. To determine laboratory prognostic indicators evidencing the development of more severe forms of the disease (pneumonia), a number of healthcare workers underwent laboratory examination during the acute period of the disease, namely: general clinical and biochemical blood tests, immunophenotyping of lymphocytes, analysis of the hemostasis system and cytokine levels. To study non-occupational risk factors of pneumonia, all healthcare workers after recovery were asked to fill in a Google form developed by the authors. The most severe clinical forms of COVID-19 were registered in healthcare workers who were older than 40 years, with low physical activity and a body mass index higher than 25.0, had diabetes mellitus and chronic diseases of the genitourinary system. When analyzing the results of laboratory tests, markers indicating development of pneumonia were identified and their critical values (cut-off points) were determined: the level of lymphocytes (below 1.955•109/l), T-cytotoxic lymphocytes (below 0.455•109/l), T-helpers (below 0.855•109/L), natural killers (below 0.205•109/l), platelets (below 239•109/L), erythrocyte sedimentation rate (above 11.5 mm/h), D-dimer (above 0.325 mcg/ml), total protein (below 71.55 g/L), lactate dehydrogenase (above 196 U/L), C-reactive protein (above 4.17 mg/l), and interleukin-6 (above 3.63 pg/l). The study identified non-occupational risk factors causing development of severe COVID-19 and established laboratory prognostic indicators.

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Section: технологии полногеномного секвенирования Sars-cov-2 для опре...unclassified

The risk of developing severe clinical forms of covid-19 in healthcare workers in the initial period of the pandemic: Non-occupational factors and laboratory prognostic indicators

Platonova¹,

Голубкова²,

Sklyar³

et al. 2023

Health Risk Analysis

View full text Add to dashboard Cite

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“…Из условий, способствующих инфицированию МР SARSCoV2, наиболее значимыми были тес ный и длительный контакт с больными COVID19, проведение манипуляций с образованием аэрозо ля (интубация трахеи, бронхоскопия, санация тра хеобронхиального дерева, забор биологического материала из рото/носоглотки, пр. ), работа в усло виях, изначально не предназначенных для оказа ния медицинской помощи инфекционным больным, кадровый дефицит и сложности свое временной ро тации специалистов, недостаточность средств ин дивидуальной защиты (СИЗ) и нарушения при их использовании [11].…”

Section: результаты и обсуждениеunclassified

The Incidence of a New Coronavirus Infection in Medical Workers and the Evaluation of the Effectiveness of Individual Technologies for their Protection at Different Stages of the Pandemic

Sisin

Голубкова

Козлова³

et al. 2022

Epidemiology and Vaccinal Prevention

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Relevance. The study of the incidence of medical workers with a new coronavirus infection during the COVID-19 pandemic is one of the topical areas of epidemiological research at this stage. The search for effective practices to reduce the incidence and risk of SARS-CoV-2 spread among employees of medical organizations is a promising area of research that is in demand in practice.Аim. Analysis of COVID-19 morbidity among health care staff during the pandemic and determination of the significance of selected specific and nonspecific prophylaxis measures in minimizing the risk of their occupational infection with SARS-CoV-2. Materials and methods. The reporting forms «General information about patients with positive COVID-19», «General information about patients with community-acquired pneumonia with positive COVID-19» (497 units of information), 2 176 cards of epidemiological investigation of cases of COVID-19 among employees of three municipalities were analyzed. We used epidemiological and statistical research methods. Conclusions. When analyzing the incidence of COVID-19 among employees of the medical worckers of the Khanty-Mansi autonomous оkrug -Yugra in the period from the 19th calendar week of 2020 to the 36th week of 2021, which corresponded to three epidemic rises, it was found that its level exceeded such in the unorganized adult population by 2.2 times, as well as the frequency of severe clinical forms of infection with lung damage. In the first two epidemic rises in the incidence, the highest incidence rate was recorded when the chances (OR) of getting COVID-19 among workers in the medical organizations compared to the adult population were the highest. In the first «wave» of the pandemic, they were 3.0, and in the second 2.6 times higher, as were the chances of developing clinical forms of COVID-19 with lung damage, which differed by 2.2 and 1.7 times, respectively, from those of an adult population (p<0.05). During the third epidemic rise, the situation changed radically. The incidence of new coronavirus infection in ,medical worckers as well as the chances of getting sick, were equal to those in the adult population (OR 1.1), while the frequency of clinical forms of infection with lung involvement was even lower than in the population (P=95.7‰).The reason for the positive changes in the dynamics of the epidemic process was due to the formation among medical workers of a higher stratum of people protected from infection due to active, emergency vaccination and people with post-infection immunity as a result of infection in its various clinical forms than in the population. A detailed analysis of the incidence of COVID-19 in three medical organizations of Khanty-Mansiysk autonomous okrug -Yugra made it possible to obtain information that among employees of medical organizations vaccinated against a new coronavirus infection, the incidence of COVID-19 was 4.4 times lower than

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“…Даже до подведения окончательных итогов 2020 г. стало понятным пре обладание вируса SARSCoV2 в качестве основ ного возбудителя при вспышках ИСМП. Результаты анализа вспышек новой коронавирусной инфек ции, связанной с оказанием медицинской помощи, были предметом пристального внимания ученых из многих стран, в том числе и России [6][7][8][9][10][11][12].…”

Section: результаты и обсуждениеunclassified

“…Впервые о вспышках COVID19 в медицин ских организациях сообщили исследователи из Китайской Народной Республики, с которой и на чалось распространение новой коронавирусной инфекции [6,7]. В дальнейшем о внутрибольничных очагах COVID19 в МО, в том числе со значительным распространением инфекции, поступала информа ция и из других стран [8][9][10][11][12].…”

Section: Introductionunclassified

Outbreaks of COVID-19 in Medical organizations

Sisin¹,

Голубкова

Козлова³

et al. 2021

Epidemiology and Vaccinal Prevention

Self Cite

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Relevance. Prevention of the outbreak of a new coronavirus infection in medical organizations (MO) is one of the tasks facing the Rospotrebnadzor service and practical health care. Analysis of the causes and conditions of the spread of SARS-CoV-2 in the MO allows us to determine the most effective measures to contain the infection and prevent the occurrence of subsequent diseases in the focus.The aim is to characterize the epidemiological features of a new coronavirus infection during its nosocomial spread in medical organizations based on the analysis of outbreak incidence.Materials and methods. The data of the reporting forms «General information on patients with positive COVID-19», «General information on patients with community-acquired pneumonia with positive COVID-19» (138 pieces of information), copies of «Acts of epidemiological investigation of foci of infectious (parasitic) diseases with the establishment of a causal relationship» (57 pieces of information), copies of extraordinary reports on an emergency of a sanitary and epidemiological nature (57 pieces of information) were analyzed. The work uses epidemiological and statistical methods of research.Results. When analyzing 57 COVID-19 outbreaks in 30 medical organizations, it was found that the outbreak incidence was more often registered in multidisciplinary hospitals – 70.2% compared to 12.3% in specialized organizations of noninfectious profile, 10.5% of outbreaks were in polyclinics, 1.8% at emergency medical stations. The total number of people affected by the spread of the infection was 961, with a small proportion of children (15 people or 1.7%). Among those who fell ill with the spread of infection in the foci, the share of employees of medical organizations was 62.6%, including doctors – 16.6%, middle and junior medical workers-50.6% and 11.3%, respectively, and other categories – 21.5%. In nosocomial outbreaks of COVID-19, the focality index corresponded to 16.9, and the average duration of the focus was 32.4 days. The construction of the so-called «combined» outbreak diagram in the course of the epidanalysis allowed us to establish its total duration, which was 71 days, with the peaks of morbidity within the outbreak at intervals of 3–7 days, the greatest number of cases in the 1st and 8th days, and the gradual «extinction» of its activity in dynamics.Conclusions. The outbreak of COVID-19 in medical organizations usually occurred when there was an epidemic problem with COVID-19 in the territory. The peculiarity of nosocomial outbreaks was a significant proportion of adults (98.3%), mainly employees of medical organizations, who were often active sources of infection, as well as the involvement of structural units and hospitals for adults in the epidemic process, a high frequency of etiological interpretation of outbreaks (95.9%), a significant proportion of asymptomatic forms of infection and carrier, and the complexity of differential diagnosis of cases of out – of-hospital and nosocomial infection. The patterns of occurrence and spread of morbidity in medical organizations can be used in practical anti-epidemic work.

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Epidemiological risks and lessons from the first wave of new coronavirus infection (COVID-19) in medical organizations

Cited by 6 publications

References 9 publications

The risk of developing severe clinical forms of covid-19 in healthcare workers in the initial period of the pandemic: Non-occupational factors and laboratory prognostic indicators

The risk of developing severe clinical forms of covid-19 in healthcare workers in the initial period of the pandemic: Non-occupational factors and laboratory prognostic indicators

The Incidence of a New Coronavirus Infection in Medical Workers and the Evaluation of the Effectiveness of Individual Technologies for their Protection at Different Stages of the Pandemic

Outbreaks of COVID-19 in Medical organizations

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