Epidemiological study of classic Kaposi’s sarcoma: a retrospective review of 125 cases from Northern Israel

Weissmann, A; Linn, Shai; Weltfriend, Sara; Friedman‐Birnbaum, Rachel

doi:10.1046/j.1468-3083.2000.00022.x

Cited by 51 publications

(60 citation statements)

References 21 publications

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“…Cevap oranları ve RT komplikasyonları Tablo 2 de gösterilmektedir. TARTIŞMA KKS sıklıkla 40-70 yaş Akdeniz erkeklerinde görü-len, prognozu diğer tiplere göre daha iyi seyreden ve Türkiye'de nadir görülen diğer tiplere kıyas-la daha yaygın olan bir neoplazmdır [2][3][4]. Bizim hastalarımızın da bir (%7,1) tanesi AIDS ile ilişkili olmak üzere diğer 13'ü (%92,9) KKS idi.…”

Section: Bulgularunclassified

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Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

et al. 2015

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Objective: In our study, we evaluated the clinical characteristics and outcomes of treatment in patients with Kaposi's sarcoma (KS). Methods:The patients undergoing radiotherapy (RT) because of the KS between the years 2005-2012 in Radiation Oncology Department of Dicle University Hospital were included. All patients underwent RT with different dose-fractionation schemes to increase quality of life and to palliate the symptoms. Patients with lesions in multiple regions underwent RT in the same or different dates. Responses to radiotherapy were recorded as complete or partial response.Results: Fourteen patients received radiotherapy because of f KS were evaluated retrospectively. Twenty two different regions of 14 patients underwent RT . Only one patient (4.5%) was performed RT to glans penis as a third region while performed to the two regions in six patients (27.3%). At irradiations, 6 MV and 10 MV photon energies with 6 MeV, 9 MeV and 12 MeV electron energy were used. Water phantom or bolus material was used to obtain a homogeneous dose distribution in the photon irradiation. RT dose administered to a total of 22 different regional was median 800 cGy (Range: 800-3000 cGy). Median number of RT fractions was 1 (Range: 1-10).When treatment response were evaluated stable disease was present in the 4 (18.1%) regions. Partial response was achieved in eight (36.4%) regions, complete response in 10 (45.5%). RT-related common lymphedema in the feet and legs was observed in the four (57.3%) regions in the acute period. Complication of pain was present in two (28.7%) regions. Conclusion:RT is an appropriate and effective treatment regimen in the palliative treatment of KS lesions. Excellent response rates of skin lesions may be obtained by RT. Lesions and symptoms such as itching may be lost after RT. Side effects such as edema and pain may be relieved by supportive treatment. Bulgular: KS nedeniyle radyoterapi uygulanan 14 hasta retrospektif olarak değerlendirildi. On dört hastanın toplam 22 farklı bölgesine RT uygulandı. Altı hastada (%27,3) iki ayrı bölge ışınlanırken, yalnız bir hastada (%4,5) üçüncü bölge olarak glans penisteki lezyona RT uygulandı. Işınla-malarda 6 MV ve 10 MV foton enerjileri ile 6 MeV, 9 MeV ve 12 MeV elektron enerjileri kullanıldı. Foton ışınlamala-rında homojen doz dağılımı elde etmek için su fantomu veya bolus materyali kullanıldı. Uygulanan RT dozu toplam 22 farklı bölge için medyan 800 cGy (800-3000 cGy) idi. RT fraksiyon sayısı medyan 1'di (1-10). Tedavi yanıt-ları değerlendirildiğinde 4 (%18,1) bölgede stabil hastalık mevcuttu. Sekiz (%36,4) tedavi bölgesinde kısmi cevap sağlanırken, 10 (%45,5) bölgede de tam cevap elde edildi. Dört (%57,3) tedavi bölgesinde RT' ye bağlı ayaklarda ve bacaklarda akut dönemde yaygın lenfödem gözlendi. İki (%28,7) bölgede ise ağrı komplikasyonu mevcuttu.Sonuç: RT, KS lezyonlarının palyatif tedavisinde uygun ve etkili bir tedavi rejimidir. RT ile cilt lezyonlarında mü-kemmel cevap oranları elde edilebilir. RT sonrası lezyonlar ve kaşıntı gibi şikayetle...

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Section: Bulgularunclassified

“…Uygulanan RT dozu toplam 22 farklı bölge için medyan 800 cGy (800-3000 cGy) idi. RT fraksiyon sayısı medyan 1'di (1)(2)(3)(4)(5)(6)(7)(8)(9)(10). Tedavi yanıt-ları değerlendirildiğinde 4 (%18,1) bölgede stabil hastalık mevcuttu.…”

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Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

et al. 2015

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“…Le VIH n'a pas été considéré car les premiers cas de diabète de type 2 cétonurique décrits en Afrique ont été rapportés à partir des années 1960, bien avant la survenue de l'infection par le VIH. Le virus de l'hépatite C qui a parfois été associé au diabète de type 2 n'a également pas été considéré car il est associé à une insulinorésistance et non pas à un déficit de l'insulinosécrétion [10,11]. (Figure 1).…”

Section: L'herpès Virus Humain De Type 8 (Hhv-8)unclassified

Diabète de type 2 cétonurique et virus de l’herpès humain de type 8

Gautier

2008

Med Sci (Paris)

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“…1 Four clinical subtypes were reported such as Classic Kaposi Sarcoma (CKS), endemic or African KS, immunosuppression associated KS, and AIDS associated KS. 2 The CKS is frequently seen in elderly people, particularly men of Mediterranean heritage or Eastern Europe Jewish (Ashkenazi) and have usually benign, slow pattern. 2,3 The lesions typically occur on the lower legs and feet in the form of macules and/or papules with progression to nodular or plaque form.…”

Section: Introductionmentioning

confidence: 99%

“…2 The CKS is frequently seen in elderly people, particularly men of Mediterranean heritage or Eastern Europe Jewish (Ashkenazi) and have usually benign, slow pattern. 2,3 The lesions typically occur on the lower legs and feet in the form of macules and/or papules with progression to nodular or plaque form. However, the features of the lesions depend on the variation of disease progression.…”

Section: Introductionmentioning

confidence: 99%

The Palliative Radiotherapy of Classic Kaposi’s Sarcoma of Foot Region: Retrospective Evaluation

Akmansu¹

2011

UHOD

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The life quality of the patients with classic Kaposi's sarcoma exit in the foot region (toes, dorsum pedis, plantar pedis and region calcaneus) were impaired due to the walking or the pain while wearing shoes. The widely used radiotherapy in this patient group is applied with different doses and fractionation schemes. The data is limited for evaluating response and toxicity of radiation to optimized radiotherapy techniques of foot' CKS. The aim of the study was to assess the effectiveness and safety of RT for these patients. Thirty-one therapy areas of 15 patients with histological confirmed Kaposi's sarcoma in the foot region and treated between 1999 and 2005 were evaluated retrospectively. The male/female ratio was 2.75/1 and the median age was 63 years of age. The most frequently used radiotherapy scheme was 3000cGy in 10 fractions. The median follow-up time was 68.4 months. The complete response ratios were 86.7%, 93.3%, 93.3% for 30 therapy areas at 6, 12 months and 5 years, consecutively. Acute complications were observed in 17 (54.8%) therapy areas. All side effects developed due to the therapy were controlled with supportive treatment. Normal foot movements were ensured within 2-4 weeks after the radiotherapy. According to our results, the radiotherapy is effective and safe therapy modality for Kaposi's sarcoma of the foot region. However, the first response to radiation is usually frustrating and it may increase the patients' complaint about the foot due to the acute toxicity. This can be improved completely with supportive therapy.Keywords: Classic Kaposi's sarcoma, Radiotherapy, Foot region ÖZET Ayak Bölgesinin Klasik Kaposi Sarkomunun Palyatif Radyoterapisi: Retrospektif De¤erlendirmeAyak bölgesinde (ayak parmaklar›, dorsum pedis, plantar pedis, regio calcanea) klasik Kaposi sarkomu bulunan hastalar›n yaflam kalitesi; yürürken veya ayakkab› giyerken çektikleri ac› nedeniyle bozulmaktad›r. Bu hasta grubunda s›kl›kla kullan›lan radyoterapi, farkl› doz ve fraksiyon flemalar› ile uygulanmaktad›r. Aya¤›n klasik Kaposi sarkomunun radyoterapi tekniklerini optimize etmek için radyasyonun yan›t›n› ve toksisitesini de¤erlendiren veri azd›r. Çal›flman›n amac› bu hastalar için radyoterapinin etkinli¤ini ve güvenilirli¤ini de¤erlendirmektir. 1999 ve 2005 y›llar› aras›nda tedavi olmufl ve ayak bölgesindeki Kaposi sarkomu histolojik olarak do¤rulanm›fl 15 hastan›n 31 tedavi bölgesi retrospektif olarak de¤erlendirilmifltir. Erkek/kad›n oran› 2.75/1'dir, medyan yafl 63'tür. En s›k kullan›lan radyoterapi flemas› 10 fraksiyonda 3000 cGy'dir. Medyan izlem süresi 68.4 ayd›r. Otuz tedavi alan› için 6, 12. aylardaki ve 5.y›ldaki tam yan›t oran› s›rayla %87, 93.3%, 93.3%'tür. Akut komplikasyonlar 17 (%54.8) tedavi alan›nda gözlenmifltir. Tedaviye ba¤-l› geliflen yan etkilerin tümü destek tedavi ile kontrol alt›na al›nm›flt›r. Radyoterapi sonras› 2-4 hafta içinde normal ayak hareketleri sa¤-lanm›flt›r. Radyoterapi ayak bölgesinin Kaposi sarkomu için etkili ve güvenli bir tedavi modalitesidir. Radyasyona ilk yan›t gen...

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Epidemiological study of classic Kaposi’s sarcoma: a retrospective review of 125 cases from Northern Israel

Cited by 51 publications

References 21 publications

Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

Kaposi sarkomu nedeniyle radyoterapi uygulanan 14 hastanın değerlendirilmesi

Diabète de type 2 cétonurique et virus de l’herpès humain de type 8

The Palliative Radiotherapy of Classic Kaposi’s Sarcoma of Foot Region: Retrospective Evaluation

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