Epidemiological study of complete and partial hydatidiform mole in Abu Dhabi: influence age and ethnic group.

Graham, Iain H.; Fajardo, Aurora M.; Richards, R. L.

doi:10.1136/jcp.43.8.661

Cited by 23 publications

(5 citation statements)

References 16 publications

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“…In this study, in case group women with age <20 years and >34 years were significantly higher (P<0.05) compared to control group which correlates with Parazzini F et al 11 and the study in Abu Dhabi 12 .…”

Section: Discussionsupporting

confidence: 86%

A Case Control Study on Selected Maternal Risk Factors of Molar Pregnancy

Khatun¹,

Khatun²,

Karim³

2021

JOPSOM

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Background: The incidence of gestational trophoblastic disease varies dramatically in different regions of the world. While there are some geographical and racial variations, perhaps a higher incidence in Africa and Asia. The high incidence of molar pregnancy in some populations have been attributed to nutritional and socioeconomic factors. Some maternal biological factors also associated with molar pregnancy. This study aims to explore the various maternal risk factors associated with molar pregnancy. Methods: This case control study was carried out among 50 molar and 100 non-molar pregnant mothers admitted at in patient department of obstetrics and gynecology, Rajshahi Medical College Hospital from January to December 2011. The patients of molar pregnancies were selected on the basis of clinically diagnosed confirmed by ultrasonogram and histopathological examination. Controls group were selected as pregnant women of 1st & 2nd trimester. With the ethical approval from the institutional review board (IRB), patients were selected after taking their written consent. A structured questionnaire and a check list were designed with considering all the variables of interest. Results: Out of 50 cases 48% belongs to the age group below 20 years, 17% belongs to the age group above 34years. 88% of the control groups are belongs to the age group 20-34 years. Out of 50 cases 4% had history of prior molar pregnancy, none of the control groups had prior history of mole. 46% of molar cases belongs to the blood group A, 82% in case group and 86% of control group were hormonal contraceptive users. Among the socio-demographic risk factors occupation, education, socioeconomic condition, nutritional status of the case and control group were included. Conclusion: Molar pregnancy largely remains as etiologic dilemma. No pregnancy is immune to develop as hydatidiform mole. As the risk factors for the disease are unclear, an attempt has been made to identify some risk factors of molar pregnancy to compare them with normal pregnancy to find out any modifiable factors. JOPSOM 2020; 39(2): 34-39

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Section: Discussionsupporting

confidence: 86%

A Case Control Study on Selected Maternal Risk Factors of Molar Pregnancy

Khatun¹,

Khatun²,

Karim³

2021

JOPSOM

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“…Increased maternal age is a well-known risk factor significantly associated with CHM (48,52,53). In studies where the genotypes of the moles were determined, this association was reported with androgenetic CHM (4).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of 204 sporadic hydatidiform moles: revisiting risk factors and their correlations with the molar genotypes

et al. 2020

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Hydatidiform mole (HM) is an aberrant human pregnancy characterized by excessive trophoblastic proliferation and abnormal embryonic development. HM have two morphological types, complete (CHM) and partial (PHM), and non-recurrent ones have three genotypic types, androgenetic monospermic, androgenetic dispermic, and triploid dispermic. Most available studies on risk factors predisposing to different types of HM and their malignant transformation mainly suffer from the lack of comprehensive genotypic analysis of large cohorts of molar tissues combined with accurate postmolar hCG follow-up. Moreover, 10-20% of patients with one HM have at least one non-molar miscarriage, which is higher than the frequency of two pregnancy losses in the general population (2-5%) suggesting a common genetic susceptibility to HM and miscarriages. However, the underlying causes of the miscarriages in these patients are unknown. Here, we comprehensively analyzed 204 HM, mostly from patients referred to the Quebec Registry of Trophoblastic Diseases and for which postmolar hCG monitoring are available, and 30 of their non-molar miscarriages. We revisited the risk of maternal age and neoplastic transformation across the different HM genotypic categories and investigated the presence of chromosomal abnormalities in their non-molar miscarriages. We confirm that androgenetic CHM are more prone to gestational trophoblastic neoplasia (GTN) than triploid dispermic PHM, and androgenetic dispermic CHM are more prone to high risk GTN and choriocarcinoma (CC) than androgenetic monospermic CHM. We also confirm the association between increased maternal age and androgenetic CHM and their malignancies. Most importantly, we demonstrate for the first time that patients with an HM and miscarriages are at higher risk for aneuploid miscarriages [83.3%, 95% confidence interval (CI) 0.653-0.944] than women with sporadic (51.5%, 95% CI 50.3-52.7%, p-value = 0.0003828) or recurrent miscarriages (43.8%, 95% CI 40.7-47.0%, p-value = 0.00002). Our data suggest common genetic female germline defects predisposing to HM and aneuploid non-molar miscarriages in some patients.

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“…This is consistent with the largest population of pregnancies at reproductive age (20-35 years). 19 The analysis results of our study in Table 1 for parity in the group of patients who undergo malignancy (GTT) show that 17 patients have 0-1 parity, 8 have 2-3 parity, and 8 have more than 4 parity. The result of parity in groups without malignancy shows that as many as 22…”

Section: Discussionmentioning

confidence: 70%

Relationship of Histopathological Representation of Excessive Proliferation of Trophoblast Cells with the Possibility of Malignant Events After Complete Hydatidiform Mole

Tobing¹,

Arabia²,

Hidayat³

et al. 2021

IJGM

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Introduction: Fifteen to twenty percent of the patients with complete hydatidiform mole transform malignancy into gestational trophoblastic tumors. The marked proliferation of trophoblastic cells is one of the characteristics that determines high risk for the occurrence of post-hydatidiform mole malignancy. The objective of the study was to analyze the histopathologic feature of the marked proliferation of trophoblastic cells as a role in posthydatidiform mole malignancy that can be used as a determinant of the risk of malignancy post-hydatidiform mole. Methods: The method of the study was analytical observational with a case-control study design. The data were taken retrospectively from medical records of patients with a post-complete hydatidiform mole malignancy and patients who do not develop postcomplete hydatidiform mole malignancy (n = 34). The study took place in the

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Epidemiological study of complete and partial hydatidiform mole in Abu Dhabi: influence age and ethnic group.

Cited by 23 publications

References 16 publications

A Case Control Study on Selected Maternal Risk Factors of Molar Pregnancy

A Case Control Study on Selected Maternal Risk Factors of Molar Pregnancy

Comprehensive analysis of 204 sporadic hydatidiform moles: revisiting risk factors and their correlations with the molar genotypes

Relationship of Histopathological Representation of Excessive Proliferation of Trophoblast Cells with the Possibility of Malignant Events After Complete Hydatidiform Mole

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