Relationship of Histopathological Representation of Excessive Proliferation of Trophoblast Cells with the Possibility of Malignant Events After Complete Hydatidiform Mole

Tobing, Maringan Diapari Lumban; Arabia, Futiha; Hidayat, Yudi Mulyana; Mantilidewi, Kemala Isnainiasih

doi:10.2147/ijgm.s271635

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…A study by Irianti (2000) showed that there were about 15-20% of hydatidiform moles turned into a malignant gestational trophoblastic tumor (GTN), even though a suction curettage had been performed [31]. This is in line with the results of a study by Tobing (2021) which showed that there was a significant difference in the histopathology of complete hydatidiform moles (73.5%) [37]. The theory proposes that a complete hydatidiform mole with excessive hyperplasia tends to turn into malignancy in the later course of the disease, which is characterized by loss of growth control.…”

Section: Length Of Stay Duration Of Treatment An Interval Of Pregnanc...supporting

confidence: 62%

Characteristics of Gestational Trophoblastic Disease at Indonesian National Referral Hospitals: A Literature Review

Sartika¹,

Sandhika²

2023

IJRP

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Gestational trophoblastic disease (GTD) is a pregnancy disorder due to an abnormality of the placenta, such as enlargement of the chorionic villi. The spectrum of GTD may range from benign to malignant. Characteristics of the gestational trophoblastic disease have been discussed in the literature. This study discussed the characteristics that resulted from previous studies and the relationship of those characteristics and gestational trophoblastic disease. The results of this study revealed that there were five national referral hospitals in Indonesia which discussed the clinical characteristics in their report on gestational trophoblastic disease, namely age, marital age, gestational age, number of parity, patient's educational level, patient's and husband job, haemoglobin levels, region of origin, ethnicity, referral cases, complaints, pregnancy intervals, -hCG levels, pregnancy history, length of stay, treatment duration, histopathology finding, staging/scoring, metastases, treatment, complications, and contraceptives. Out of the 25 characteristics that has been analyzed, 16 were studied to determine their relationships to gestational trophoblastic disease, while the other 9 were only analyzed descriptively.

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Section: Length Of Stay Duration Of Treatment An Interval Of Pregnanc...supporting

confidence: 62%

Characteristics of Gestational Trophoblastic Disease at Indonesian National Referral Hospitals: A Literature Review

Sartika¹,

Sandhika²

2023

IJRP

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“…In Western countries, the incidence of hydatidiform mole ranges from 1:1,450 to 1:2,000 pregnancies, while choriocarcinoma occurs in 1:14,000 to 1:40,000 pregnancies. Furthermore, the prevalence of GTD is reportedly higher in developing countries [2]. Hydatidiform mole occurs in 1:51 to 1:141 pregnancies in Indonesia, and 1:28 to 1:105 pregnancies in West Java [3].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of Referral Patients with Gestational Trophoblastic Neoplasia in Dr. Hasan Sadikin General Hospital Bandung

Mantilidewi,

Zaenudin,

Harsono

et al. 2023

Indonesian Journal of Cancer

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Background: : Gestational trophoblastic disease (GTD) is a heterogeneous group of lesions caused by abnormal trophoblast proliferation and the malignant form is called gestational trophoblastic neoplasia (GTN). Dr. Hasan Sadikin General Hospital, located in Bandung, West Java, is one of the main cancer referral hospitals in Indonesia. Consequently, the characteristics of GTN patients in this hospital can represent the general population in the province. This study aimed to elaborate on the characteristics of referral patients with GTN in Dr. Hasan Sadikin General Hospital.Methods: : Medical records of post-molar GTN patients in Dr. Hasan Sadikin General Hospital from between January 2019 to December 2020 were collected and analyzed. GTN was diagnosed according to the International Federation in Gynecology and Obstetrics (FIGO) criteria. Additionally, both the sociodemographic and clinical characteristics of patients were evaluated.Results: The results showed that among the 160 participants in this study, the overall mean age was 33±8.7 years, with a mean βhCG level of 241,461.81±630,557.90 mIU/mL. Moreover, approximately 16.3% had gestosis and 5% were diagnosed with hyperthyroidism. The majority of post-molar observations at the hospital were not carried out according to standards, with only 8.1% of patients receiving optimal surveillance. About 56.8% visited the hospital due to vaginal bleeding, while most histopathological results showed complete hydatidiform moles (44.4%), and choriocarcinomas (16.3%). Most of the patients were diagnosed as stage I (81.9%), had lowrisk FIGO scores (80.6%), and were treated with methotrexate (80.6%).Conclusions: GTN patients in Dr. Hasan Sadikin General Hospital showed clinical characteristics consistent with previous studies. The low percentage of patients receiving optimal post-molar surveillance could cause delayed referral. This suboptimal surveillance might be due to the high cost of βhCG testing, lack of facilities, and low patient compliance in West Java

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Case Report: Methotrexate and Etoposide as Adjuvant Therapy on Patient with Hydatidiform Moles that Have Growing Rapidly Becomes Gestational Trophoblastic Neoplasia

Supriyono

2022

EJMED

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A hydatidiform mole is a type of placental abnormality that is associated with gestational trophoblastic disease (GTD). It can be complete or partial mole. They are typically considered benign, but they are also premalignant, with the potential to become malignant and invasive to other organs (gestational trophoblastic neoplasia/GTN). Management of the hydatiform moles is curettage therapy and suction, which aims to therapy and diagnostic. Follow-up post evacuation of moles must be tight with serum hCG and clinical examination. When there is evidence of vaginal bleeding and an increase in serum hCG, chemotherapy must be used as an adjuvant. This case report intends to persuade clinicians that adjuvant therapy with chemotherapy combination-based Methotrexate/MTX and etoposide can recover and eliminate vaginal bleeding disorders. On her first pregnancy, a woman of 27 years old develops a complete hydatiform mole. The curettage and suction procedure were then performed twice. She also receives chemotherapy in three series of single MTX and three series of MTX plus Etoposide. Following this therapy, the patient recovers, normal hCG level and has no vaginal bleeding problems.

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Relationship of Histopathological Representation of Excessive Proliferation of Trophoblast Cells with the Possibility of Malignant Events After Complete Hydatidiform Mole

Cited by 3 publications

References 10 publications

Characteristics of Gestational Trophoblastic Disease at Indonesian National Referral Hospitals: A Literature Review

Characteristics of Gestational Trophoblastic Disease at Indonesian National Referral Hospitals: A Literature Review

Characteristics of Referral Patients with Gestational Trophoblastic Neoplasia in Dr. Hasan Sadikin General Hospital Bandung

Case Report: Methotrexate and Etoposide as Adjuvant Therapy on Patient with Hydatidiform Moles that Have Growing Rapidly Becomes Gestational Trophoblastic Neoplasia

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