Epidemiological Study of Severe Cases of Meniere's Disease in Japan

Shojaku, Hideo; Watanabe, Yukio; Mizukoshi, Kanemasa; Kitahara, Masaaki; Yazawa, Yoshiro; Watanabe, Isamu; Ohkubo, Jin

doi:10.3109/00016489509125286

Cited by 17 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Even when considering the different diagnostic criteria and the variable follow-up periods in previous reports as reasons for the variable prevalence of BMD, the 5.4% prevalence of BMD seems to be lower than in other reports (Table IV). 1,6,[17][18][19] If we consider the studies with strict diagnostic criteria for BMD, bilaterality in the Caucasian population has been reported in 2% to 47% of MD patients. 2 Although the lowest prevalence was 2%, most studies reported 20% to 50% prevalence of bilateral involvement in the Caucasian population.…”

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group

et al. 2018

View full text Add to dashboard Cite

Objectives/Hypothesis To identify the clinical characteristics of patients with bilateral Meniere's disease (MD) in an Asian population. Study Design Cross‐sectional retrospective study. Methods We compared the clinical features of bilateral MD (BMD) and unilateral MD (UMD) in 320 Asian patients with single ethnicity. Demographic variables; age of onset; inner ear function; the coexistence of related disorders such as vestibular migraine, delayed MD, systemic autoimmune diseases, and familial MD; and prognoses were analyzed and compared. Results The overall prevalence of BMD was 5.6%. The mean age of disease onset was 40.3 ± 14.8 and 47.0 ± 14.1 years for patients with BMD and UMD, respectively (P = .07). Demographic variables were not significantly different between patients with BMD and UMD (P > .05). Inner ear function, evaluated by hearing thresholds, caloric tests, and cervical vestibular evoked myogenic potentials, was significantly more deteriorated in the first involved ear of patients with BMD than in the second involved ear or the affected side of patients with UMD (P < .05). Among the comorbid conditions, only the prevalence of delayed MD was significantly higher in patients with BMD than in patients with UMD. Systemic autoimmune disease was found in only three patients with UMD. There was no significant prognostic difference between patients with UMD and BMD (P > .05). Conclusions A low prevalence of BMD, a higher frequency of delayed MD in BMD patients, and a low frequency of systemic autoimmune diseases in both UMD and BMD patients are significant findings in an Asian population. Level of Evidence 4 Laryngoscope, 129:1191–1196, 2019

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Characteristics of Bilateral Meniere's Disease in a Single Asian Ethnic Group

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Due to bilateral vestibulopathy, patients with bilateral MD experience chronic debilitating vestibular symptoms, such as oscillopsia and imbalance, and a broad range of cognitive and emotional impairment ( 6 ). Moreover, bilateral MD often leads to severe to profound hearing loss with unserviceable speech discrimination ( 7 , 8 ). A biomarker for future bilateral disease would allow clinicians to identify those patients, to preemptively counsel them about the expected disease course, and to personalize therapy regimens in clinically meaningful ways.…”

Section: Introductionmentioning

confidence: 99%

Radiological Configuration of the Vestibular Aqueduct Predicts Bilateral Progression in Meniere's Disease

Bächinger

Schuknecht²,

Dlugaiczyk

et al. 2021

Front. Neurol.

View full text Add to dashboard Cite

Objective: Meniere's disease (MD) progresses from unilateral to bilateral disease in up to 50% of patients, often chronically and severely impairing balance and hearing functions. According to previous studies, 91% of bilateral MD patients demonstrate bilateral hypoplasia of the endolymphatic sac (ES) upon histological and radiological examination of their inner ears. Here, we seek to validate a radiological marker for ES hypoplasia that predicts the risk for future progression to bilateral MD in individual patients.Methods: Patients with unilateral MD and radiological evidence for ES hypoplasia in either the clinically affected inner ear (cohort MDuni-hpuni) or both inner ears (cohort MDuni-hpbi) were included. Given our hypothesis that ES hypoplasia critically predisposes the inner ear to MD, we expected progression to bilateral MD only in the MDuni-hpbi cohort. To investigate eventual progression to bilateral MD, clinical, audiometric, and imaging data were retrospectively collected over follow-up periods of up to 31 years.Results: A total of 44 patients were included in the MD-hpuni (n = 15) and MDuni-hpbi (n = 29) cohorts. In line with our radiology-based predictions, none (0/15) of the MD-hpuni patients exhibited progression to bilateral MD, whereas 20/29 (69%) MD-hpbi patients have already progressed to bilateral MD. Using the Kaplan–Meier estimator, bilateral disease progression would be observed in 100% of MD-hpbi patients 31 years after the initial diagnosis with an estimated median time to bilateral progression of 12 years. The nine MD-hpbi patients who, so far, remained with unilateral disease demonstrated a median time since initial (unilateral) MD diagnosis of only 6 years and are thus still expected to progress to bilateral disease.Conclusion: Progression to bilateral MD adheres to predictions based on the radiological presence or absence of ES hypoplasia. This prognostic tool, if validated by prospective long-term studies, will provide clinically relevant information about a patient's future disease burden and will help to select more personalized treatment regimens.

show abstract

“…La mayoría de los casos comienzan por la aparición de síntomas en un oído y secuencialmente evolucionan hacia la enfermedad bilateral. La frecuencia de conversión de unilateral a bilateral no está clara, varios estudios lo sitúan entre el 5% y 50% dependiendo de los criterios utilizados audiológicos y de la duración del seguimiento [8,9]. Por lo general, el número de pacientes con EM que progresan a forma bilateral con hipoacusia neurosensorial (HNS) severa o profunda bilateral es relativamente pequeña, aproximadamente un 6% [8].…”

Section: Introductionunclassified