Epidemiological survey of neurological diseases in a tribal population cluster in Gujarat

Parkinson’s disease (PD) is a common neurodegenerative disease that is a growing public health challenge. Estimates of the burden of PD have focused on data from high-income countries, with lower-income countries poorly described. We reviewed and examined the prevalence of PD reported by studies in low- to upper-middle-income countries. A systematic literature search was performed in the Medline/PubMed, Embase, LILACS, and Web of Science databases. Age group, sex, and geographic region were considered when analyzing the data. Of the 4327 assessed articles, 57 met the inclusion criteria for qualitative review, and 36 were included in the meta-analysis. Heterogeneity measures were high both as a whole and in each geographic region. Data analysis by geographic region showed that reported prevalence differed across regions, ranging from 49 per 100,000 (Sub-Saharan Africa) to 1081 per 100,000 (Latin America and the Caribbean). There was an increasing prevalence of PD with advancing age (per 100,000): 7 in 40–49 years, 158 in 50–59 years, 603 in 60–69 years, 1251 in 70–79 years, and 2181 in over the age of 80. The prevalence of PD in men and women was similar. There was a greater PD prevalence in populations with a higher 5-year GDP per capita and a higher life expectancy. Our findings suggest a higher prevalence of PD in lower and upper-middle-income countries than previously reported. Comparisons between regions are difficult, as the sociocultural differences and lack of methodological standardization hinder understanding key epidemiological data in varied populations.

show abstract

Global Prevalence and Incidence of Amyotrophic Lateral Sclerosis

Wolfson

Gauvin

Ishola

et al. 2023

Neurology

View full text Add to dashboard Cite

Background and Objectives:Amyotrophic Lateral Sclerosis (ALS) is a rare neurodegenerative disorder affecting upper and lower motor neurons. Due to its rarity and rapidly progressive nature, studying the epidemiology of ALS is challenging and a comprehensive picture of the global burden of this disease is lacking. The objective of this systematic review was to describe the global incidence and prevalence of ALS.Methods:We searched Medline, Embase, Global Health, PsycInfo, Cochrane Library, and CINAHL to identify articles published between January 1st, 2010, and May 6th, 2021. Studies that were population-based and reported estimates of prevalence, incidence, and/or mortality of ALS, were eligible for inclusion. This paper focuses on incidence and prevalence. Quality assessment was performed using a tool developed to evaluate methodology relevant to prevalence and incidence studies. This review was registered with PROSPERO, CRD42021250559.Results:This search generated 6,238 articles, of which 140 were selected for data extraction and quality assessment. Of these, 85 articles reported on incidence and 61 on prevalence of ALS. Incidence ranged from 0.26 per 100,000 person-years in Ecuador to 23.46 per 100,000 person-years in Japan. Point prevalence ranged from 1.57 per 100,000 in Iran to 11.80 per 100,000 in the United States. Many articles identified ALS cases from multiple data sources.Discussion:There is variation in reported incidence and prevalence estimates of ALS across the world. While registries are an important and powerful tool to quantify disease burden, such resources are not available everywhere. This results in gaps in reporting of the global epidemiology of ALS, as highlighted by the degree of variation (and quality) in estimates of incidence and prevalence reported in this review.

show abstract

Epidemiological survey of neurological diseases in a tribal population cluster in Gujarat

Cited by 8 publications

References 20 publications

A late-onset Parkinson's disease in tribes in India – A case report

A late-onset Parkinson's disease in tribes in India – A case report

A systematic review and meta-analysis of the prevalence of Parkinson’s disease in lower to upper-middle-income countries

Global Prevalence and Incidence of Amyotrophic Lateral Sclerosis

Contact Info

Product

Resources

About