Épidémiologie du carcinome hépatocellulaire : simple augmentation d’incidence ou futur drame ?

Raoul, Jean‐Luc; Raimbourg, Judith; Hiret, Sandrine; Adhoute, Xavier; Senellart, Hélène

doi:10.1016/j.bulcan.2018.02.003

Cited by 3 publications

(2 citation statements)

References 62 publications

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“…Ceci montre la similarité des aspects radiologiques des cancers ovariens et de la tuberculose péritonéale. Les lésions hépatiques malignes étaient majoritaires à 76% dominées par le carcinome hépatocellulaire qui reste la première tumeur primitive du foie (9). La biopsie hépatique dans ce contexte était liée au fait que la présentation radiologique des lésions focales hépatiques n'était pas typique de carcinome hépatocellulaire.…”

Section: Discussionunclassified

Apport des prélèvements percutanés échoguidés dans le diagnostic des tumeurs au centre hospitalier national universitaire Aristide Ledantec : à propos de 180 cas

Administrateur- JAIM,

FAYE Ibrahima,

DIOP Abdoulaye Dione

et al. 2023

J Afr Imag Méd

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Objective: To review the activities of ultrasound-guided percutaneous sampling in the radiology department of Aristide Ledantec Hospital. Material and method: This was a retrospective descriptive study over a 2-year period from June 2018 to June 2020 at Aristide Ledantec National University Hospital. All patients who underwent percutaneous ultrasound-guided sampling with available histological results were included. The samples taken were either biopsies performed with tru-cut needles or cytopunctures with 22G needles. Data analysis was performed using SPSS version 2.2 software which allowed us to collect 180 patients. Results: The average age of the patients was 38 years with extremes ranging from 5 to 74 years. Women represented 90% and men 10%. Biopsies accounted for 85.5% compared to 14.5% of cytopunctures and 2.7%. Non-contributory specimens accounted for 2.7%. Benign lesions accounted for 54% while 46% were malignant. Breast lesions accounted for 71.66%, liver lesions for 7.22%, soft tissue and ovarian lesions for 5.5% each, thyroid lesions for 3.3%, bone and lymph nodes for 2.22% each, pancreatic lesions for 1.6% and adrenal lesions for 0.55%. Of the breast lesions, 86% were biopsies and 14% were cytopunctures. 55.04% were benign and 42.64% were malignant. Adenofibromas were in the majority (43.66%) among the benign lesions while infiltrating adenocarcinomas dominated the malignant lesions and accounted for 92.73%. Of the 10 ovarian lesions biopsied, 7 were malignant and 03 were in favour of tuberculosis. There were 16 liver biopsies with 76.92% malignant lesions and 7.69% benign lesions corresponding to an adenoma. All pancreatic lesions (03) were adenocarcinomas. However, no complications were observed. Conclusion: Ultrasound-guided percutaneous sampling is an interventional radiology procedure that helps to obtain the histological type of a tumour without resorting to surgery. RESUME Objectif : Faire le bilan des activités des prélèvements percutanés guidés par l’échographie au service de radiologie de l’hôpital Aristide Ledantec. Matériel et méthode : Il s’agissait d’une étude rétrospective descriptive sur une période de 2 ans allant de juin 2018 à juin 2020 au centre hospitalier national universitaire Aristide Ledantec. Était inclus tout patient ayant bénéficié d’un prélèvement percutané écho guidé avec résultat histologique disponible. Les prélèvements effectués étaient soit des biopsies effectuées par des aiguilles de tru-cut ou des cytoponctions avec de l’aiguille 22G. L’analyse des données a été effectuée par le logiciel SPSS version 2.2 qui nous avait permis de colliger 180 patients. Résultats : L’âge moyen des patients était de 38 ans avec des extrêmes allant de 5 à 74 ans. Les femmes représentaient 90% et les hommes 10%. Les biopsies représentaient 85,5% contre 14,5% de cytoponctions. Les prélèvements non contributifs représentaient 2,7%. Les lésions bénignes représentaient 54% tandis que 46% étaient malignes. Les lésions mammaires représentaient 71,66%, lésions hépatiques 7,22%, tissus mous et les lésions ovariennes 5.5% chacun, les lésions thyroïdiennes 3,3%.Les tissus osseux et ganglionnaires représentaient chacun 2,22 %, les lésions pancréatiques représentaient 1,6% et les lésions surrénaliennes 0,55%. Parmi les lésions mammaires, 86% étaient des biopsies contre 14% de cytoponctions, elles étaient bénignes dans 55,04% et malignes dans 42,64%. Les adénofibromes étaient majoritaires (43.66%) parmi les lésions bénignes tandis les l’adénocarcinome infiltrant dominait les lésions malignes et représentaient 92,73%. Sur les 10 lésions ovariennes biopsiées les 7 étaient malignes et les 03 étaient en faveur d’une tuberculose. Les biopsies hépatiques étaient au nombre 16 avec 76,92% de lésions malignes et 7,69 % de lésions bénignes correspondant à un adénome. Toutes les lésions pancréatiques (03) étaient des adénocarcinomes. Aucune complication n’a été observée. Conclusion : Les prélèvements percutanés guidés par l’échographie sont des actes de radiologie interventionnelle contribuant à obtenir le type histologique d’une tumeur sans faire recours à la chirurgie.

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Section: Discussionunclassified

Apport des prélèvements percutanés échoguidés dans le diagnostic des tumeurs au centre hospitalier national universitaire Aristide Ledantec : à propos de 180 cas

Administrateur- JAIM,

FAYE Ibrahima,

DIOP Abdoulaye Dione

et al. 2023

J Afr Imag Méd

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“…Hepatocellular carcinoma (HCC) is a highly lethal tumor, which is the third most frequent cause of cancer-associated mortality with an increasing incidence rate worldwide ( 1 ). Accurate and timely diagnoses of HCC are often challenging.…”

Section: Introductionmentioning

confidence: 99%

Identification of hub genes in peripheral blood mononuclear cells for the diagnosis of hepatocellular carcinoma using a weighted gene co‑expression network analysis

Zeng

Shen

et al. 2020

Exp Ther Med

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Human hepatocellular carcinoma (HCC) is a common malignant tumor of the digestive tract that is prevalent worldwide. Improving diagnosis methods for HCC helps to improve patient survival rate. The present study aimed to identify novel HCC biomarkers for the diagnosis of HCC through analyzing gene changes on peripheral blood mononuclear cells (PBMCs) and verifying these in additional samples. The gene expression profiles GSE49515 (including 10 specimens from normal patients and 10 specimens from patients with HCC) and GSE58208 (including 5 specimens from normal patients and 10 specimens from patients with HCC) were downloaded from the online Gene Expression Omnibus database (GEO). Differentially expressed genes (DEGs) in PBMCs between healthy controls and patients with HCC were identified using R software. A total of 935 DEGs, including 686 upregulated DEGs and 249 downregulated DEGs, were identified in the present study. In order to identify any internal associations, these DEGs were used to construct weighted gene co-expression networks (WGCNA). Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of genes in each module were conducted using the online database DAVID. Furthermore, hub genes with high module membership were identified in a co-expression network and receiver operating characteristic curves were used to verify the diagnostic values of these eight hub genes. Furthermore, the expression and diagnosis value of the eight hub genes were also verified in additional samples. The results of the present study suggested that secreted protein acidic and cysteine rich(SPARC), transmembrane protein 40 (TMEM40), solute carrier family 25 member 44, formyl peptide receptor 2 (FPR2), complement C8 β chain, N-myristoyltransferase 1, protein kinase C δ(PRKCD) and protein phosphatase, Mg 2+ /Mn 2+ dependent 1M(PPM1M) were hub genes. SPARC, TMEM40, FPR2, PRKCD and PPM1M had prominent diagnostic value according to the results from the GEO data and the additional samples. The present study demonstrated that these hub genes may help to improve the diagnosis of HCC.

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Overexpression of CMTM7 inhibits cell growth and migration in liver cancer

Huang

Yang

et al. 2019

The Kaohsiung J of Med Scie

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Chemokine‐like factor (CKLF)‐like, MAL and related proteins for vesicle trafficking and membrane link (MARVEL) transmembrane domain‐containing family proteins (CMTMs) have significant roles in the immune system, in male reproduction, as well as in tumorigenesis. Previous studies have shown that CMTM family member 7 (CMTM7) was broadly expressed in various normal tissues, but not in lung, gastric, esophageal, pancreas, and cervix cancers. To explore its relationship with liver cancer, we examined the expression of CMTM7 in liver cancers and its correlation with clinical and pathological conditions. We found that CMTM7 expression was markedly reduced in liver cancer tissues, and negatively correlated with TNM staging and tumor metastasis. In vitro studies showed that enforced expression of CMTM7 inhibited the cell growth and migration of liver cancer cells. Further analysis revealed that CMTM7 suppressed AKT signaling and induced cell cycle arrest at the G0/G1 phase in the liver cancer cells, likely as the consequent of decreased levels of cyclin D1, cyclin‐dependent kinase 4 (CDK4), and CDK6, and increased p27 expression. Thus, CMTM7 functions as a tumor suppressor in liver cancer through suppressing cell cycle progression.

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Épidémiologie du carcinome hépatocellulaire : simple augmentation d’incidence ou futur drame ?

Cited by 3 publications

References 62 publications

Apport des prélèvements percutanés échoguidés dans le diagnostic des tumeurs au centre hospitalier national universitaire Aristide Ledantec : à propos de 180 cas

Apport des prélèvements percutanés échoguidés dans le diagnostic des tumeurs au centre hospitalier national universitaire Aristide Ledantec : à propos de 180 cas

Identification of hub genes in peripheral blood mononuclear cells for the diagnosis of hepatocellular carcinoma using a weighted gene co‑expression network analysis

Overexpression of CMTM7 inhibits cell growth and migration in liver cancer

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