Épidémiologie et caractéristiques cliniques du glaucome congénital primitif

Aziz, Azliana; Fakhoury, Omar; Matonti, F.; Pieri, Emmanuelle; Denis, D.

doi:10.1016/j.jfo.2015.04.018

Cited by 11 publications

(4 citation statements)

References 16 publications

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“…This is in accordance with other published reports, as in the studies by Zagora et al 4 reporting bilateral involvement in 67.1% of PCG cases and the study by Yassin and Al-Tamimi 5 reporting bilateral involvement in 74% of PCG cases and is in contradistinction to other published reports, as in the study by Aziz et al 6 reporting bilateral involvement in 99.3% of cases, the study by Tamcelik et al 7 reporting bilateral involvement in 94.4% of cases, the study by Alanazi et al 8 reporting bilateral involvement in 82.6% of PCG cases, and the study by Taylor et al 1 reporting bilateral involvement in 82% of PCG cases. This higher bilaterality incidence in those reports may be related to the disease severity and underlying genetic abnormality in different communities and ethnic groups.…”

Section: Discussionsupporting

confidence: 91%

Fellow Eye in Unilateral Primary Congenital Glaucoma

Bayoumi

2017

Journal of Current Glaucoma Practice

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AimThis is a report of the incidence of bilateral cases in a cohort of primary congenital glaucoma (PCG) cases and a study of the biometric characteristics of the fellow normal eyes in unilateral cases.Materials and methodsThe charts of 134 PCG children were reviewed, of which 78 cases (58.2%) were found to have bilateral disease. The remaining 56 patients (41.8%) with unilateral disease had their fellow normal eyes compared with an age-matched cohort of ophthalmologically free children.ResultsThere were no differences between the normal fellow eyes of PCG cases and the control eyes in the corneal diameter and central corneal thickness (CCT), whereas the normal fellow eyes of PCG cases had higher intraocular pressure (IOP) and cup/disc (C/D) ratios.ConclusionThe fellow eyes of apparently unilateral PCG cases are not typically normal anatomically like other children unaffected by PCG.Clinical significanceA very high index of suspicion has to be kept for PCG cases that present apparently unilaterally, and meticulous prolonged follow-up is mandatory.How to cite this articleBayoumi NHL. Fellow Eye in Unilateral Primary Congenital Glaucoma. J Curr Glaucoma Pract 2017;11(1):28-30.

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Section: Discussionsupporting

confidence: 91%

Fellow Eye in Unilateral Primary Congenital Glaucoma

Bayoumi

2017

Journal of Current Glaucoma Practice

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“…Французские авторы приводят несколько иные данные по своей стране: по результатам ретроспективного эпидемиологического исследования, проведенного в период с 1999 по 2014 г. и включившего 71 ребенка (141 глаз) с ПВГ, семейный анамнез был выявлен в 28 % случаев, поражение носило двусторонний характер в 99,3 % случаев. Мальчиков и девочек среди участников исследования было примерно одинаково (50,7 и 49,3 % соответственно) [36].…”

Section: западная европаunclassified

“…Как правило, наблюдается небольшое преобладание мальчиков среди больных ПВГ [2,34,35,47]. Авторы из Индии и Франции говорят примерно об одинаковом количестве мальчиков и девочек [19,36], а немецкие ученые выявили более высокую распространенность ПВГ среди девочек [41,42].…”

Section: западная европаunclassified

Genetic Epidemiology of Primary Congenital Glaucoma in the World. Part II

Oganezova,

Kadyshev,

Egorov

2024

Oftalʹmologiâ

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This publication continues a review published in December 2023 about the genetic epidemiology and genotype-phenotype correlations in primary congenital glaucoma (PCG) worldwide, and presents data from East and South Asia, Western Europe and Russia. Analysis of the incidence of PCG data in these regions shows that the rates for Western Europe, the European part of Russia and East Asia are comparable and average 1:10,000–18,000 newborns and higher in ethnically mixed groups. On the territory of South Asia, the minimum number of children with PCG was recorded in Nepal, and the maximum in India. The majority of researchers talk about the predominance of bilateral process in 62 to 99 % cases. As a rule, there is a slight predominance of boys among patients with PCG; authors from India and France report approximately the same number of boys and girls, and German scientists have found a higher prevalence of PCG among girls. If we talk about the phenotype of the disease, almost all researchers note a more severe course in subgroups with the presence of CYP1B1 mutations than in patients who do not have a mutation in this gene. As for the genetic causes of PCG, the most common are mutations in the CYP1B1 gene, accounting for up to a third of cases in India, Pakistan, Western Europe and the European part of Russia. In East Asian patients, mutations in the CYP1B1 gene are most likely not the main ones in the pathogenesis of PCG, because are found much less frequently and often only in one allele. Chinese scientists say that it is necessary to pay attention to mutations TEK and ZC2HC1C, VPS13D, PGF.

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“…Данните от заболяването в Европейския съюз са, че засяга 1 на 27 800 живородени деца, като по-често засегнати са момчетата. При 70-80% от случаите засягането е двустранно [5].…”

Section: обсъжданеunclassified

Congenital Glaucoma – Case Reports

Bratovanova

Kostova

Toshev

et al. 2021

Bulgarian Review of Ophthalmology

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Резюме. Конгениталната глаукома е рядко, но застрашаващо зрението заболяване, което е с автозомно-рецесивно унаследяване. Високото вътреочно налягане се дължи на аномалии в развитието на преднокамерния ъгъл и не се асоциира с други очни или системни аномалии. Установяват се трабекуларна дисгенеза и типични глаукомни промени в очното дъно. В патогенезата на заболяването е доказано участието на генни мутации на GLC3A и GLC3B. Цел: Да представим клинични случаи с доказана конгенитална глаукома и да анализираме изхода от лечението. Материал: Новородено на 7-месечна възраст от мъжки пол и дете на 1 год. и 5 мес. от женски пол, постъпващи за пореден път в Очна клиника на УМБАЛ "Александровска"-София. Методи: Пълен офталмологичен преглед, оглед под обща анестезия, тонометрия, ехобиометрия, гониоскопия и рефракция. Резултат: Единият пациент е с едностранна глаукома, двукратно опериран с последваща консервативна локална терапия. Другото дете е с двустранно заболяване, еднократна операция на двете очи и не изисква допълнително топикално лечение. И двете деца са с риск от депривационна амблиопия. Заключение: Конгениталната глаукома е социалнозначимо заболяване поради лошата прогноза за зрението. Често се налагат повече от една операция, както и поддържащо консервативно лечение. Необходим е доживотен мониторинг на ВОН и състоянието на ретинния неврофибриларен слой.

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Épidémiologie et caractéristiques cliniques du glaucome congénital primitif

Cited by 11 publications

References 16 publications

Fellow Eye in Unilateral Primary Congenital Glaucoma

Fellow Eye in Unilateral Primary Congenital Glaucoma

Genetic Epidemiology of Primary Congenital Glaucoma in the World. Part II

Congenital Glaucoma – Case Reports

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