Epidemiology and aetiology of neonatal seizures

Vasudevan, Chakrapani; Levene, Malcolm I.

doi:10.1016/j.siny.2013.05.008

Cited by 201 publications

(173 citation statements)

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“…9 The early occurrence of seizures is probably due to the high occurrence of HIE in many studies. 10 .The most common cause of seizure was HIE (37.9%) which was comparable with Sood A et al who reported 45.7% as due to birth asphyxia 11 . Kumar A also reported birth asphyxia as the commonest cause of seizure in first 48 hrs of life 4 .…”

Section: Discussionsupporting

confidence: 79%

Comparison of Clinical and Etiologic Profile of Neonatal Seizures Over A Decade.- A Hospital Based Prospective Study

Geetha¹

2017

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Section: Discussionsupporting

confidence: 79%

Comparison of Clinical and Etiologic Profile of Neonatal Seizures Over A Decade.- A Hospital Based Prospective Study

Geetha¹

2017

jmscr

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“…Abnormal tone and hypo/ areflexia, lethargy, poor sucking, muscular hypotonia, irritability and apnea may be evident although they can be found in more common acute neonatal disorders like sepsis, severe heart insufficiency or HIE [3]. The co-occurrence of metabolic acidosis, hypoglycemia, cardiac disorders and liver disease may be supportive features [5,6].…”

Section: Overview Of Clinical Manifestationsmentioning

confidence: 99%

“…Neonates may present with different types of seizures: clonic, tonic, myoclonic (axial, focal, erratic), epileptic spasms, and subtle seizures, including autonomic signs or automatisms [2]. Seizures in the neonatal period differ considerably from those observed later in life with respect to their aetiological profile and clinical presentation [2,3]. NS often represent the first clinical indicator of a central nervous system (CNS) dysfunction.…”

Section: Introductionmentioning

confidence: 99%

“…NS often represent the first clinical indicator of a central nervous system (CNS) dysfunction. Although 40-50% of them are secondary to hypoxicischemic encephalopathy (HIE), other less frequent etiologies must be taken into account in the diagnostic work-up including infections, cortical malformations (readily identifiable through routine testing and imaging) and inborn errors of metabolism (IEMs) [3,4]. Diagnosis can be quite difficult, thus, a high index of suspicion is required [4].…”

Section: Introductionmentioning

confidence: 99%

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Neonatal Seizures and Inborn Errors of Metabolism: An Update

Parisi¹,

Nicotera²,

Alagna³

et al. 2015

Int J Pediatr Neonat Care

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Early identification of an underlying inborn error of metabolism in newborns with otherwise unexplained seizures may address appropriate disease-specific treatment and provide important tools about the choice of the antiepileptic drugs.Neonatal seizures usually present as prolonged or recurrent, often configuring epileptic status. Striking features of an underlying metabolic disorder include abnormal neurological examination, lethargy and/ or symptoms of acute decompensation.Ex adiuvantibus, trial with intravenous pyridoxine administration could be attempted in refractory unexplained neonatal seizures. Peculiar EEG patterns such as Suppression Burst may address diagnosis and laboratory work-up being most frequently associated to specific metabolic disorders.

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“…Gestasyonel yaşın yanı sıra doğum kilosunun da nöbet görülme sıklığında artışla bağlantısı olmakla beraber, bazı çalışmalar prematüre bebeklerdeki bu sık insidans oranını muhtemelen bu grupta epileptik olmayan nöbetlerin alınmış olmasına bağlamaktadır. [1,2] Yeni doğan nöbetleri dört ana grupta ele alınmaktadır; sinsi nöbetler, klonik, tonik ve miyoklonik nöbetler.…”

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Newborn Seizures

YALCINKAYA¹

2014

Epilepsi

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ÖzetYenidoğan nöbetlerinin görülme sıklığı miadında doğanlar için %2-3, prematüre bebekler için %10-15 civarındadır. Yeni doğan nöbetleri, çocukluk ve yetişkin dönemindekilerden farklı klinik görünümlere ve elektroansefalografi (EEG) bulgularına sahip olması nedeniyle farklı bir önem taşımaktadır; nitekim bu dönemde pek çok paroksizmal olay ebeveynlerce sık olarak bildirilir ancak çoğu epileptik nöbet değildir. Diğer yandan klinik olarak tipik bir nöbet tablosunda EEG bulguları normal ya da oldukça atipik olabilmektedir. Bu yaş grubunda etiyolojinin oldukça zengin hastalık gruplarından oluşması ve altta yatan nedenlerin de prognoz ile ilişkili olması ayrıca vurgulanmalıdır. Bu yazıda yeni doğan nöbetleri sinsi nöbetler, klonik, tonik ve miyoklonik nöbetler olmak üzere dört ana grupta ele alınmaktadır.Anahtar sözcükler: Nöbet; yenidoğan. SummaryThe incidence of newborn seizures is reported as 2-3% for term infants and as 10-15% for premature infants. Newborn seizures carry a special importance because they have different clinical and electroencephalographic (EEG) characteristics than childhood and adolescent seizures; nevertheless, many paroxysmal events are commonly reported by parents though most of them are usually not epileptic of origin. On the other hand, in the presence of a typical epileptic seizure, EEG findings may be normal or atypical. Numerous underlying disorders in this age group and prognostic influence of these disorders should also be underlined. In this paper, newborn seizures are discussed in four main groups as insidious seizures, clonic, tonic and myoclonic seizures.

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Epidemiology and aetiology of neonatal seizures

Cited by 201 publications

References 50 publications

Comparison of Clinical and Etiologic Profile of Neonatal Seizures Over A Decade.- A Hospital Based Prospective Study

Comparison of Clinical and Etiologic Profile of Neonatal Seizures Over A Decade.- A Hospital Based Prospective Study

Neonatal Seizures and Inborn Errors of Metabolism: An Update

Newborn Seizures

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