Epidemiology and burden of invasive fungal infections in the countries of the Arab League

Kmeid, Joumana; Jabbour, Jean-Francois; Kanj, Souha S.

doi:10.1016/j.jiph.2019.05.007

Cited by 49 publications

(41 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our study conforms with worldwide observations about the predominance of NAC [ 12 ], with 64.7% of the episodes caused by non- albicans species. Recent studies in the Arab countries were concordant with this global trend, reporting NAC rates of around 70% [ 8 ]. However, we found that C. glabrata is the most common causative agent for NAC in Lebanon (51.4% of speciated NAC).…”

Section: Discussionmentioning

confidence: 56%

“…Although candidemia remains a cause of significant mortality and high economic burden worldwide, studies on candidemia in the Arab world remain limited, [ 8 ] with no data from Lebanon [ 11 ]. We report herein the first large series of candidemia at a tertiary hospital in Lebanon, detailing the characteristics, epidemiology, and outcomes of 170 candidemia episodes over a 16-year period.…”

Section: Discussionmentioning

confidence: 99%

“…Data on candidemia from Arab countries are limited [ 8 ]. In the absence of national surveillance programs, data are largely based on local studies.…”

Section: Introductionmentioning

confidence: 99%

“…In the absence of national surveillance programs, data are largely based on local studies. The crude mortality rate of candidemia in Arab countries is also elevated, and NAC is becoming more predominant as well [ 8 ]. In Lebanon, no studies have been previously done to evaluate the epidemiology of invasive candidiasis or candidemia.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Predominance of Candida Glabrata among Non-albicans Candida Species in a 16-Year Study of Candidemia at a Tertiary Care Center in Lebanon

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background: Candidemia is associated with a high mortality rate, and its incidence is increasing worldwide with a rise in non-albicans candidemia (NAC). Epidemiologic data from Arab countries are scarce and there are no data from Lebanon; Methods: This is a single-center retrospective chart review of patients with candidemia in a tertiary care center in Lebanon from 2004 to 2019. We extracted data on patient characteristics, isolated Candida species antifungal susceptibility, management and outcomes; Results: We included 170 cases of candidemia. NAC was more common than albicans candidemia (64.7% vs. 35.3%). C. glabrata was the most common non-albicans species (37 isolates) followed by C. tropicalis (14). Recent use of antifungals was a risk factor for NAC (OR = 2.8, p = 0.01), while the presence of a central venous catheter was protective (OR = 0.41, p = 0.02). Fluconazole resistance was 12.5% in C. albicans and 21.5% in non-albicans spp. Mortality at 30 days was 55.5%, with no difference between NAC and albicans candidemia. It was higher in older and critically ill patients but lower in patients whose central venous catheter was removed after detecting fungemia; Conclusions: Candidemia is associated with high mortality in Lebanon, with a predominance of NAC and high prevalence of C. glabrata.

show abstract

Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

“…Data on candidemia from Arab countries are limited [ 8 ]. In the absence of national surveillance programs, data are largely based on local studies.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Predominance of Candida Glabrata among Non-albicans Candida Species in a 16-Year Study of Candidemia at a Tertiary Care Center in Lebanon

et al. 2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…So far these species only constitute a small number of all invasive Candida infections [5], but these rare species might become increasingly important in the future, particularly with respect to resistance to antifungals [6]. Globally, the burden of invasive Candida infections, just like the burden of other invasive fungal infections, is rising [7,8,9]. For example, Candida is responsible for an estimated 2000–12,000 invasive fungal infections per year in Germany alone [10].…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Performance of a Novel Multiplex PCR Assay for Candidemia among ICU Patients

Fuchs

Lass‐Flörl

Posch

2019

JoF

View full text Add to dashboard Cite

Candidemia poses a major threat to ICU patients and is routinely diagnosed by blood culture, which is known for its low sensitivity and long turnaround times. We compared the performance of a novel, Candida-specific multiplex real-time PCR assay (Fungiplex® Candida IVD Real-Time PCR Kit) with blood culture and another established diagnostic real-time PCR assay (LightCycler SeptiFast Test) with respect to Candida detection from whole blood samples. Clinical samples from 58 patients were analyzed by standard blood culture (BC) and simultaneously tested with the Fungiplex Candida PCR (FP) and the SeptiFast test (SF) for molecular detection of Candida spp. Compared to BC, the FP test showed high diagnostic power, with a sensitivity of 100% and a specificity of 94.1%. Overall diagnostic accuracy reached 94.6%. Using SF, we found a sensitivity of 60%, a specificity of 96.1%, and an overall diagnostic accuracy of 92.9%. The Fungiplex Candida PCR has shown good sensitivity and specificity on clinical samples of high-risk patients for direct detection of Candida species in whole blood samples. Together with conventional diagnostics (BC and antigen testing), this new multiplex PCR assay may contribute to a rapid and accurate diagnosis of candidiasis.

show abstract

Candidiasis, Drug Resistance, and Translational Research

Jha,

Kumar

2024

Recent Advances in Human Fungal Diseases

View full text Add to dashboard Cite

Epidemiology and burden of invasive fungal infections in the countries of the Arab League

Cited by 49 publications

References 50 publications

Predominance of Candida Glabrata among Non-albicans Candida Species in a 16-Year Study of Candidemia at a Tertiary Care Center in Lebanon

Predominance of Candida Glabrata among Non-albicans Candida Species in a 16-Year Study of Candidemia at a Tertiary Care Center in Lebanon

Diagnostic Performance of a Novel Multiplex PCR Assay for Candidemia among ICU Patients

Candidiasis, Drug Resistance, and Translational Research

Contact Info

Product

Resources

About