Epidemiology and burden of multidrug-resistant bacterial infection in a developing country

Lim, Cherry; Takahashi, Emi; Hongsuwan, Maliwan; Wuthiekanun, Vanaporn; Thamlikitkul, Visanu; Hinjoy, Soawapak; Day, Nicholas P. J.; Peacock, Sharon J.; Limmathurotsakul, Direk

doi:10.7554/elife.18082

Cited by 251 publications

(193 citation statements)

References 24 publications

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“…Nevertheless, rates as high as 71.73% were detected in Pakistan (Ullah et al, 2009). On the opposite side, another study conducted in Northeast Thailand illustrated that only 14% of K. pneumoniae isolates were MDR which is substantially lower than ours (Lim et al, 2016). Such discrepant results could be ascribed to the regional variances in antibiotic usage guidelines as well as infection control strategies.…”

Section: Characteristics Of the Mdr K Pneumoniae Isolatescontrasting

confidence: 68%

In vitro Susceptibility of Multidrug-Resistant Klebsiella pneumoniae Isolates from an Egyptian Tertiary Care Hospital to Tigecycline and Colistin

Kady¹,

Gouda²

2017

Int.J.Curr.Microbiol.App.Sci

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Section: Characteristics Of the Mdr K Pneumoniae Isolatescontrasting

confidence: 68%

In vitro Susceptibility of Multidrug-Resistant Klebsiella pneumoniae Isolates from an Egyptian Tertiary Care Hospital to Tigecycline and Colistin

Kady¹,

Gouda²

2017

Int.J.Curr.Microbiol.App.Sci

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“…from a value of at least 28 mg per kg final weight, as recorded in the present study, to one below 5 mg per kg final weight. In Thailand, increases in the incidence of community-acquired antimicrobial-resistant bacterial infection 8 , 18 and colistin-resistant bacteria in the stools of healthy people 19 have been observed. These observations may be at least partially attributable to the routine exposure of millions of Thai chickens to colistin and several other medically important antibiotics.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic use in poultry: a survey of eight farms in Thailand

Wongsuvan

Wuthiekanun

Hinjoy

et al. 2017

Bull. World Health Organ.

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ObjectiveTo investigate antibiotic use in poultry farms in Thailand and estimate the total amount of antibiotics used annually in Thai production of chicken meat.MethodsIn a single province, we surveyed eight farms in which chickens were raised for meat and interviewed the farms’ owners in 2016. The antibiotic use for each chicken was defined as the amount of antibiotic given to the chicken over its entire lifetime divided by the target weight of the chicken at the time of its slaughter. Assuming that the results were nationally representative, we estimated annual antibiotic use on all Thai chickens raised for meat.FindingsNo use of antibiotics for growth promotion was reported. Five farms raised 1-kg chickens for company A and reportedly used no antibiotics unless the chickens were sick. The other three farms raised 3-kg chickens for company B and reported routine use of antibiotics for prophylaxis. Per kg final weight, each chicken raised for company B was reportedly routinely given a mean of 101 mg of antibiotics – that is, 33 mg of amoxicillin, 29 mg colistin, 19 mg oxytetracycline, 18 mg doxycycline and 2 mg tilmicosin. The total amount of antibiotic used on all Thai chickens raised for meat in 2016 was estimated to be 161 tonnes.ConclusionEach year in Thailand, many tonnes of antibiotics are probably routinely used in raising chickens for meat. Labels on retail packs of meat should include data on antibiotic use in the production of the meat.

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“…1,2 Blood cultures can be used to identify common pathogenic organisms causing both community- 3 and hospital-acquired infections. 4 Blood cultures are also crucial for monitoring antimicrobial resistance (AMR), both in hospitals 5 and nationally. 6 …”

mentioning

confidence: 99%

Capacity and Utilization of Blood Culture in Two Referral Hospitals in Indonesia and Thailand

Teerawattanasook

Tauran

Teparrukkul

et al. 2017

The American Journal of Tropical Medicine and Hygiene

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Abstract.It is generally recommended that sepsis patients should have at least two blood cultures obtained before antimicrobial therapy. From 1995 to 2015, the number of blood cultures taken each year in a 1,100-bed public referral hospital in Ubon Ratchathani northeast Thailand rose from 5,235 to 56,719, whereas the number received in an 840-bed referral public hospital in South Sulawesi, Indonesia, in 2015 was 2,779. The proportion of patients sampled for blood cultures out of all inpatients in South Sulawesi in 2015 (9%; 2,779/30,593) was lower than that in Ubon Ratchathani in 2003 (13%; 8,707/66,515), at a time when health expenditure per capita in the two countries was comparable. Under-use of bacterial cultures may lead to an underestimate and underreporting of the incidence of antimicrobial-resistant infections. Raising capacity and utilization of clinical microbiology laboratories in developing countries, at least at sentinel hospitals, to monitor the antimicrobial resistance situation should be prioritized.

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Epidemiology and burden of multidrug-resistant bacterial infection in a developing country

Cited by 251 publications

References 24 publications

In vitro Susceptibility of Multidrug-Resistant Klebsiella pneumoniae Isolates from an Egyptian Tertiary Care Hospital to Tigecycline and Colistin

In vitro Susceptibility of Multidrug-Resistant Klebsiella pneumoniae Isolates from an Egyptian Tertiary Care Hospital to Tigecycline and Colistin

Antibiotic use in poultry: a survey of eight farms in Thailand

Capacity and Utilization of Blood Culture in Two Referral Hospitals in Indonesia and Thailand

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