Epidemiology and Clinical Characteristics of Influenza C Virus

Sederdahl, Bethany K.; Williams, John V.

doi:10.3390/v12010089

Cited by 42 publications

(42 citation statements)

References 109 publications

(174 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this context, in Japan at least, reemergence of the C/Kanagawa lineage was detected in 1996 and it continued to circulate together with C/São Paulo lineage viruses, which emerged in 2004 and spread widely, throughout the study period and beyond. Our observation of ICV outbreaks occurring 2 years apart in Hong Kong is notable given the evidence of biennial ICV epidemics in Japan ( 7 ), with similar trends having been indicated in studies from other countries, as reviewed in Sederdahl and Williams ( 43 ). The occurrence of biennial epidemics is suggestive of herd immunity temporarily curtailing ICV circulation after each peak of transmission and an inability of the HEF glycoprotein to accommodate frequent antigenic drift substitutions in light of functional constraints.…”

Section: Discussionsupporting

confidence: 84%

“…Seropositivity for ICV is as high as 90% in children by 7 to 10 years of age, indicating that it is a major cause of acute respiratory illness that goes undiagnosed due to presentation as mild “cold-like” symptoms in the vast majority of cases ( 42 , 43 ), with only more severe cases seeking medical assistance and even fewer being tested for the virus ( 43 ). This, linked with low isolation rates for ICV, has meant there have been relatively few viruses available for study, and consequently, while numbers of HE gene sequences have been adequate, small numbers of full-genome sequences have been available for analysis ( 38 ).…”

Section: Discussionmentioning

confidence: 99%

“…While ICV infection is generally viewed as a mild disease of children, there are numerous reports showing that reinfection can occur, even in later life, and an increasing number that describe severe disease in children with associated economic burden (reviewed in references 10 and 43 ). This evolving understanding of ICV epidemiology related to the prevalence and recurrence of multiple lineages, together with potential cross-species transmission, raises public health concern.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Molecular Characterization of Influenza C Viruses from Outbreaks in Hong Kong SAR, China

Daniels

Tse²,

Ermetal

et al. 2020

J Virol

View full text Add to dashboard Cite

In 2014 the Centre for Health Protection in Hong Kong introduced screening for influenza C virus (ICV) as part of its routine surveillance for infectious agents in specimens collected from patients presenting with symptoms of respiratory viral infection, including Influenza-Like Illness. A retrospective analysis of ICV detections up to week 26/2019 revealed persistent low-level circulation with two outbreaks having occurred in the winters of 2015-16 and 2017-18. These outbreaks occurred at the same time as, and were dwarfed by, seasonal epidemics of influenza types A and B. Gene sequencing studies on stored ICV-positive clinical specimens from the two outbreaks have shown the HE genes of the viruses to fall in two of the six recognised genetic lineages (represented by C/Kanagawa/1/76 and C/São Paulo/378/82) with there being significant genetic drift compared to earlier circulating viruses within both lineages. The location of a number of encoded amino acid substitutions in HEF glycoproteins suggests antigenic drift may also have occurred. Observations of ICV outbreaks in other countries, with some of the infections being associated with severe disease, indicates that ICV infection has the potential to have significant clinical and health care impact in humans. IMPORTANCE Influenza C virus infection of humans is common and re-infection can occur throughout life. While symptoms are generally mild, severe disease cases have been reported, but knowledge of the virus is limited as little systematic surveillance for influenza C virus is conducted and the virus cannot be studied by classical virologic methods as the virus cannot be readily isolated in laboratories. A combination of systematic surveillance in Hong Kong SAR, China and new gene sequencing methods has been used in this study to assess influenza C virus evolution and provided evidence for a two-year cycle of disease outbreaks. The results of studies like that reported here are key to developing an understanding of the impact of influenza C virus infection in humans and how virus evolution might be associated with epidemics.

show abstract

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular Characterization of Influenza C Viruses from Outbreaks in Hong Kong SAR, China

Daniels

Tse²,

Ermetal

et al. 2020

J Virol

View full text Add to dashboard Cite

show abstract

“…Recent developments in RT-PCR for COVID-19 detection have given rise to a greater understanding of the clinical characteristics and molecular epidemiology of COVID-19. 5 Since most of the patients with the earliest onset had been exposed to the south China seafood market in Wuhan, it was widely believed that COVID-19 originated from wild animals sold in the market. Shi et al 6 reported that the natural host of COVID-19 might be bats; the team found that the full genome sequence of the COVID-19 obtained from the confirmed patient was 96% similar to the bat coronavirus, and it was also demonstrated that COVID-19 acts on the receptor angiotensin-converting enzyme 2 through the same cells as severe acute respiratory syndrome coronavirus (SARS-CoV).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Clinical Characteristics of COVID-19

et al. 2020

View full text Add to dashboard Cite

Since December 2019, there has been an outbreak of a novel coronavirus (COVID-19) infection in Wuhan, China. Meanwhile, the outbreak also drew attention and concern from the World Health Organization (WHO). COVID-19 is another human infectious disease caused by coronavirus. The transmission of COVID-19 is potent and the infection rate is fast. Since there is no specific drug for COVID-19, the treatment is mainly symptomatic supportive therapy. In addition, it should be pointed out that patients with severe illness need more aggressive treatment and meticulous care. Recently, accurate RNA detection has been decisive for the diagnosis of COVID-19. The development of highly sensitive RT-PCR has facilitated epidemiological studies that provide insight into the prevalence, seasonality, clinical manifestations and course of COVID-19 infection. In this review, we summarize the epidemiology and characteristics of COVID-19.

show abstract

“…Influenza C is a lesser known influenza virus, mostly causing mild upper respiratory infections in children. Influenza C has a worldwide distribution, with a higher seroprevalence in individuals in the third decade of life and progressive decrease in older adults 39 . Despite being known as a cause of mild respiratory infections in young children, it has also been described as a causative agent in severe respiratory infections in adults, particularly among immunocompromised patients 40 .…”

Section: Influenzamentioning

confidence: 99%

Coronavirus and other airborne agents with pandemic potential

Fernández-Montero

Soriano

Barreiro

et al. 2020

Current Opinion in Environmental Science & Health

View full text Add to dashboard Cite

The recent emergence of a novel coronavirus (SARS-CoV-2) has caused a pandemic, in what is the most severe infectious disease outbreak in many decades. Other infective agents such as Influenza as well as other neglected viruses such as Lassa, Nipah or Poxviruses are also a cause for concern due to its attack rate and potential for global spread. Drug-resistant bacteria, such as Mycobacterium tuberculosis are already a significant public health issue in many countries, and it is expected that they will be expanding in the near future. Finally, airborne bioterrorism agents have high morbidity and mortality rates, and should be looked with concern in the current international unrest.

show abstract

Epidemiology and Clinical Characteristics of Influenza C Virus

Cited by 42 publications

References 109 publications

Molecular Characterization of Influenza C Viruses from Outbreaks in Hong Kong SAR, China

Molecular Characterization of Influenza C Viruses from Outbreaks in Hong Kong SAR, China

Epidemiology and Clinical Characteristics of COVID-19

Coronavirus and other airborne agents with pandemic potential

Contact Info

Product

Resources

About