Epidemiology and clinical features of rotavirus, adenovirus, and astrovirus infections and coinfections in children with acute gastroenteritis prior to rotavirus vaccine introduction in Meerut, North India

Akdag, Ali Ilter; Gupta, Shipra; Khan, Naushad; Upadhayay, Amit; Ray, Pratima

doi:10.1002/jmv.25645

Cited by 24 publications

(16 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present data showed that there was a high percentage (37.4 %) of co-infection in this study among HAdV-F-positive samples. The results obtained here were consistent with those of previous studies, which have reported worldwide occurrence rates of viral co-infections ranging from 8.0-44.8 % [12,72,[76][77][78][79][80]. The most common co-infection obtained was a dual infection with HAdV-F and RVA, with a detection rate of 21.5 %, in contrast to reports from India (16.1%) [80], France (16 %) [81], Nigeria (5.9 %) [72] and previous studies conducted in Brazil (8.3 %) [21] with lower detection rates.…”

Section: Discussionsupporting

confidence: 93%

Viral gastroenteritis in Tocantins, Brazil: characterizing the diversity of human adenovirus F through next-generation sequencing and bioinformatics

Tahmasebi

Luchs

Tardy

et al. 2020

Journal of General Virology

View full text Add to dashboard Cite

Human enteric adenovirus species F (HAdV-F) is one of the most common pathogens responsible for acute gastroenteritis worldwide. Brazil is a country with continental dimensions where continuous multiregional surveillance is vital to establish a more complete picture of the epidemiology of HAdV-F. The aim of the current study was to investigate the molecular epidemiology of HAdV-F using full-genome data in rural and low-income urban areas in northern Brazil. This will allow a genetic comparison between Brazilian and global HAdV-F strains. The frequency of HAdV-F infections in patients with gastroenteritis and molecular typing of positive samples within this period was also analysed. A total of 251 stool samples collected between 2010 and 2016 from patients with acute gastroenteritis were screened for HAdV-F using next-generation sequencing techniques. HAdV-F infection was detected in 57.8 % (145/251) of samples. A total of 137 positive samples belonged to HAdV-F41 and 7 to HAdV-F40. HAdV-F40/41 dual infection was found in one sample. Detection rates did not vary significantly according to the year. Single HAdV-F infections were detected in 21.9 % (55/251) of samples and mixed infections in 37.4 % (94/251), with RVA/HAdV-F being the most frequent association (21.5 %; 54/251). Genetic analysis indicated that the HAdV-F strains circulating in Brazil were closely related to worldwide strains, and the existence of some temporal order was not observed. This is the first large-scale HAdV-F study in Brazil in which whole-genome data and DNA sequence analyses were used to characterize HAdV-F strains. Expanding the viral genome database could improve overall genotyping success and assist the National Center for Biotechnology Information (NCBI)/GenBank in standardizing the HAdV genome records by providing a large set of annotated HAdV-F genomes.

show abstract

Section: Discussionsupporting

confidence: 93%

Viral gastroenteritis in Tocantins, Brazil: characterizing the diversity of human adenovirus F through next-generation sequencing and bioinformatics

Tahmasebi

Luchs

Tardy

et al. 2020

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…This result matches recent reports in the Republic of Congo (10.3%) 13 and India (12.5%). 14 However, our finding is higher than previous results in Kenya (6.3%), 15 Northwest Ethiopia (3.6%), 8 lower than others obtained in Egypt by El Taweel et al (2020): 28%, 16 and Nigeria: 40.4%. 17 The higher prevalence obtained in Egypt may be due to the inclusion of novel human astrovirus types.…”

Section: Discussioncontrasting

confidence: 77%

“…Astrovirus diarrhea is a common infection both in developed and developing countries, which suggests that the improvement of the hygiene and living conditions alone cannot prevent such infection. 8,[13][14][15][16][17][18] Development of an astrovirus vaccine and its administration in early life may have a role in reducing this infection in early life and even decrease the incidence of astrovirus diarrhea with increasing age. 19 Regarding the clinical features associated with diarrhea in HAstV positive patients, the degrees of dehydration (mild, moderate, and severe) were detected in astrovirus positive cases with no significant association of classic HAstV with any of them (p=0.463).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular study of human astrovirus in Egyptian children with acute gastroenteritis

Zaki¹,

Mashaly²,

Alsayed³

et al. 2020

Germs

View full text Add to dashboard Cite

Introduction Human astrovirus (HAstV) has been increasingly identified as an important cause of acute gastroenteritis in young children. Limited information is available about the prevalence and genotype distribution of classic HAstV causing acute gastroenteritis in Egyptian children.Methods Stool samples were collected from 100 infants and children attending the gastroenterology outpatient clinic in Mansoura University Children Hospital and suffering from acute gastroenteritis during the period extending from January 2018 to January 2019. Samples were tested for HAstV using reverse transcription PCR. Genotyping was performed using type-specific reverse transcription nested PCR.Results Among 100 children included in this study, the detection rate of HAstV was 11% (11 patients). There was a significant difference regarding age between cases positive and negative for HAstV (p=0.005). There was a higher prevalence of HAstV in children aged one year or younger. Significant association was detected between HAstV positive cases and rural residence (p=0.002), summer season (p=0.025) and fever (p=0.017). The HAstV genotypes detected were HAstV-8 (8/11, 72.7%), HAstV-3 (2/11, 18.2%) and HAstV-2 (1/11, 9.1%).Conclusions This study suggests that HAstV is a common pathogen causing gastroenteritis in Egyptian children especially in rural areas. The most frequent HAstV genotype in our study was HAstV-8. Keywords Astrovirus, gastroenteritis, diarrhea, children, genotypes. Introduction1Acute gastroenteritis or infectious diarrhea is a common cause of morbidity and mortality in children below five years. The reported mortality rates in 2016 were 446,000 for children below 5 years. Most of these deaths are in developing

show abstract

“…Human Astroviruses (HAstVs; family Astroviridae) are common aetiological agents of acute paediatric gastroenteritis, after rotavirus and the caliciviruses (Platts-Mills et al 2015;Vu et al 2017;Wohlgemuth et al 2019), and are detected at rates comparable to adenoviruses in cases of paediatric diarrhoea (Andreasi et al 2008;Levidiotou et al 2009;Hamkar et al 2010;Akdag et al 2020). HAstV-associated gastroenteritis is also reported in the adult population, particularly in the elderly and individuals with compromised immunity (Vu et al 2017;Wohlgemuth et al 2019).…”

Section: Astrovirusesmentioning

confidence: 99%

Occurrence of Human Enteric Viruses in Water Sources and Shellfish: A Focus on Africa

2021

View full text Add to dashboard Cite

Enteric viruses are a diverse group of human pathogens which are primarily transmitted by the faecal-oral route and are a major cause of non-bacterial diarrhoeal disease in both developed and developing countries. Because they are shed in high numbers by infected individuals and can persist for a long time in the environment, they pose a serious threat to human health globally. Enteric viruses end up in the environment mainly through discharge or leakage of raw or inadequately treated sewage into water sources such as springs, rivers, dams, or marine estuaries. Human exposure then follows when contaminated water is used for drinking, cooking, or recreation and, importantly, when filter-feeding bivalve shellfish are consumed. The human health hazard posed by enteric viruses is particularly serious in Africa where rapid urbanisation in a relatively short period of time has led to the expansion of informal settlements with poor sanitation and failing or non-existent wastewater treatment infrastructure, and where rural communities with limited or no access to municipal water are dependent on nearby open water sources for their subsistence. The role of sewage-contaminated water and bivalve shellfish as vehicles for transmission of enteric viruses is well documented but, to our knowledge, has not been comprehensively reviewed in the African context. Here we provide an overview of enteric viruses and then review the growing body of research where these viruses have been detected in association with sewage-contaminated water or food in several African countries. These studies highlight the need for more research into the prevalence, molecular epidemiology and circulation of these viruses in Africa, as well as for development and application of innovative wastewater treatment approaches to reduce environmental pollution and its impact on human health on the continent.

show abstract

Epidemiology and clinical features of rotavirus, adenovirus, and astrovirus infections and coinfections in children with acute gastroenteritis prior to rotavirus vaccine introduction in Meerut, North India

Cited by 24 publications

References 34 publications

Viral gastroenteritis in Tocantins, Brazil: characterizing the diversity of human adenovirus F through next-generation sequencing and bioinformatics

Viral gastroenteritis in Tocantins, Brazil: characterizing the diversity of human adenovirus F through next-generation sequencing and bioinformatics

Molecular study of human astrovirus in Egyptian children with acute gastroenteritis

Occurrence of Human Enteric Viruses in Water Sources and Shellfish: A Focus on Africa

Contact Info

Product

Resources

About