Epidemiology and control of mekongi schistosomiasis

Urbani, Carlo Enrico; Sinoun, M.; Socheat, Duong; Pholsena, K.; Strandgaard, Hanne; Odermatt, Peter; Hatz, Christoph

doi:10.1016/s0001-706x(02)00047-5

Cited by 80 publications

(55 citation statements)

References 14 publications

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“…A comparable finding was obtained in a 2-year cohort study in Stung Treng province in Cambodia for S. mekongi between 1997 and 1999 (Hatz, 2001). While at the start of the cohort only 18.1% of subjects had a normal liver ultrasonographic assessment (pattern A or B of Niamey protocol), after 2 years 81.6% did not reveal pathological liver lesions (Urbani et al, 2002). But, in all patients, the resolution of liver morbidity was incomplete.…”

Section: Discussionmentioning

confidence: 91%

“…However, an ulrasonographic assessment was performed in 1997 in a S. mekongi-endemic village in the Stung Treng province (north of Kratie province). Of 223 subjects, 73% were found positive for S. mekongi, and periportal thickening and/or portal vein enlargement was diagnosed in 84% (Urbani et al, 2002). Therefore, it is reasonable to assume that sub-clinical morbidity was present in comparable frequencies for 1995 in the Kratie province.…”

Section: Discussionmentioning

confidence: 99%

“…Mortality due to this parasite was shown to be dramatic in non-treated transmission areas Urbani et al, 2002), occurring mostly through oesophageal bleeding. Recently, a case of cerebral infection has been described (Houston et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

“…Clinical manifestations, such as hepatomegaly and splenomegaly, and/or reports of blood and mucus in stool have been drastically reduced in schoolchildren in four sentinel villages, between 1995 and 2002, as have the numbers of schistosomiasis patients diagnosed in the health facilities in the endemic area (Urbani et al, 2002). The infection rates were monitored annually by stool analysis of schoolchildren in four sentinel villages.…”

Section: Introductionmentioning

confidence: 99%

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Liver morbidity due to Schistosoma mekongi in Cambodia after seven rounds of mass drug administration

Keang¹,

Odermatt

Odermatt-Biays³

et al. 2007

Transactions of the Royal Society of Tropical Medicine and Hygi

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Summary Severe liver disease due to Schistosoma mekongi was frequent in northern Cambodia. Between 1995 and, seven rounds of mass chemotherapy (praziquantel) reduced infection from 50% to below 3%. In 2002, we assessed hepatosplenic morbidity by historical, clinical and ultrasonographic investigations in adults (older than 14 years) from endemic (n = 342) and non-endemic (n = 103) areas (Kratie province). Clinical hepatomegaly (25 vs. 0%), splenomegaly (55 vs. 0%), reported blood in stool (41 vs. 20%) and abdominal pain (78 vs. 57%) were significantly higher in the endemic area. In this area, significantly more subjects reported a family history of death due to schistosomiasis (12 vs. 0%); 63% (vs. 0%) reported having at least three treatments of praziquantel in previous years; and only 11% (vs. 99%) had normal liver ultrasonographic examination. Periportal fibrosis with portal hypertension was diagnosed in 46% (vs. 0%) of people in this area; 18% (vs. 0%) and 5% (vs. 0%) of portal hypertension was classified as moderate and severe, respectively. People aged between 24 and 35 years were mostly affected. There was no gender difference. The pathology in the endemic district is most probably residual morbidity of S. mekongi infections. Contributions of co-infections (hepatitis) cannot be excluded. Careful monitoring of the affected communities is required.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Liver morbidity due to Schistosoma mekongi in Cambodia after seven rounds of mass drug administration

Keang¹,

Odermatt

Odermatt-Biays³

et al. 2007

Transactions of the Royal Society of Tropical Medicine and Hygi

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“…1 S. mekongi uses the freshwater snail Neotricula aperta (family Pomatiopsidae, subfamily Triculinae) as an intermediate host to complete its lifecycle 2,3 ; α-, β-, and γ-strains of N. aperta can be differentiated by shell size, shape, sculpture, mantle pigment patterns, ecology, time of development, and minor aspects of anatomy. Of these, the γ-strain is the most important vector for S. mekongi.…”

Section: Introductionmentioning

confidence: 99%

A New Population and Habitat for Neotricula aperta in the Mekong River of Northeastern Thailand: A DNA Sequence-Based Phylogenetic Assessment Confirms Identifications and Interpopulation Relationships

Limpanont

Chusongsang

et al. 2015

The American Society of Tropical Medicine and Hygiene

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Abstract. Neotricula aperta (Gastropoda: Pomatiopsidae), the snail intermediate host of Schistosoma mekongi, is found in Cambodia, Laos, and Thailand. We update information on the distribution of this species in the Mekong River and its tributary, the Mun River, in Thailand. DNA sequences of a portion of the mitochondrial cytochrome c oxidase subunit 1 were obtained from N. aperta collected from different locations and used to confirm species and strain identities. Specimens of the β-strain were found in the Mun River, whereas specimens of the γ-strain were found in the Mekong River. The γ-strain (with molecular confirmation of identity) is newly reported from Nong Khai Province, where it occurred in a habitat novel for this species: under paving slabs instead of under natural bed rocks, where agal aufwuchs is extensively located on the islet in the middle of the Mekong River. The new location is approximate 400 km upstream from the nearest previously known site for this species.

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Schistosomes: Asian

Kojima

2010

Topley &Amp; Wilson's Microbiology and Microbial Infections

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Epidemiology and control of mekongi schistosomiasis

Cited by 80 publications

References 14 publications

Liver morbidity due to Schistosoma mekongi in Cambodia after seven rounds of mass drug administration

Liver morbidity due to Schistosoma mekongi in Cambodia after seven rounds of mass drug administration

A New Population and Habitat for Neotricula aperta in the Mekong River of Northeastern Thailand: A DNA Sequence-Based Phylogenetic Assessment Confirms Identifications and Interpopulation Relationships

Schistosomes: Asian

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