Epidemiology and genotype distribution of human papillomavirus (HPV) in women of Henan Province, China

Shen, Yong; Gong, Jiao-Mei; Li, Yanqing; YuMei, Gong; Lei, Dongmei; Cheng, Guangming; Li, Xiaofu

doi:10.1016/j.cca.2012.11.005

Cited by 27 publications

(31 citation statements)

References 25 publications

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“…In the present study, the most prevalent HPV genotype was HPV 16, followed by HPV 52 and HPV 58 (Table 1), which was similar to the findings of a previous study of the prevalence of HPV infection in Henan province (8) . However, in another study conducted in this area, the most prevalent HPV genotype was HPV 16 (9.2%, 53/578), followed by HPV 52 (7.8%, 45/578) and HPV 6 (6.9%, 40/578) (9) .…”

supporting

confidence: 81%

Prevalence and genotype distribution of human papillomavirus: implications for cancer screening and vaccination in Henan province, China

Zhao

Yan

et al. 2016

Rev. Soc. Bras. Med. Trop.

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Introduction: To provide information for cervical cancer screening and vaccination in Henan province, China, the distribution of human papillomavirus (HPV) was analyzed. Methods: The HPV genotypes were detected using gene array and flowthrough hybridization. Results: Overall, 38.1% (1,536/4,033) of the women were human papillomavirus deoxyribonucleic acid (HPV DNA) positive. The prevalence of high-risk HPV types was 32.4%. HPV 16 was the most prevalent genotype (8.9%), followed by HPV 52 (5.8%) and HPV 58 (4.4%). Conclusions: The data support close surveillance of women for cervical cancer screening, and HPV prophylactic vaccines including HPV16, HPV 52, and HPV 58 might offer greater protection in this area.

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supporting

confidence: 81%

Prevalence and genotype distribution of human papillomavirus: implications for cancer screening and vaccination in Henan province, China

Zhao

Yan

et al. 2016

Rev. Soc. Bras. Med. Trop.

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“…Epidemiological data pointed to HPV 58 as the second most prevalent HR type in South America, after HPV 16 [19]. That status is supported by the findings of this study, where HPV 52 and HPV 58 shared almost the same prevalence (i.e.…”

Section: Discussionsupporting

confidence: 80%

Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality

Vargas

J²,

Guerrero³

et al. 2016

Acta Cytologica

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Objectives: To estimate the frequency of human papillomavirus (HPV) infection and the genotype distribution of HPV among women with a Pap smear showing atypical squamous cells of undetermined significance (ASC-US) attending the Program for the Detection and Control of Cervical Cancer in Bogotá, Colombia. Study Design: Cervical samples from 200 women with an ASC-US Pap smear were analyzed for the presence of HPV DNA and genotype distribution using a commercial molecular technique (Linear Array®; Roche Molecular Systems, USA). Results: HPV infection was found in 140 women (70%). High-risk HPV types were present in 46.4% of the samples; 16.4% showed a low-risk HPV type, and 37.1% showed both. Of the positive samples, 42.9% were infected with a single viral genotype, whereas 57.1% exhibited multiple HPV infections. The most common HPV genotypes were HPV 16, 53, and 52 with a prevalence of 26.4, 16.4, and 13.6%, respectively. Conclusion: The epidemiological characterization of HPV infections described in this study might guide actions for epidemiological surveillance to strengthen the program in Bogotá and to develop appropriate HPV vaccination programs.

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“…Moreover, the small size of group in our study may be one of the reason of lower positivity of multiple HPV infections. However, in a worldwide pooled analysis of 167 adenocarcinoma of the cervix patients, the multiple-infection rate was 8.9%, obviously lower than the simple infection prevalence of 91.1% [18]. Thus, our data which reflected Multiple HPV infections might be indeed be associated with the development of cervical lesions, or women with multiple HPV infections might be more susceptible to cervical carcinogenesis, or multiple HPV infections might produce conditions that confer immunological protection against persistent infection [40].…”

Section: Discussionmentioning

confidence: 99%

“…For example, HPV16 is slightly more prevalent in Europe and North America, HPV 31 is more prevalent in South/Central America, HPV 33 and 45 are more prevalent in Africa, and HPV 52 and 58 are more prevalent in Asia [9, 11–17]. Furthermore, the data from mainland China indicated that HPV16, 18, 33, and 58 were the most common types in women with CC in Henan, central China [18], whereas HPV16, 58, 18 and 33 were the most prevalent types in CIN2+ (high-grade cervical lesions, including CINII/III, and CC) in women in Liaoning, northeast China [19], and HPV16 and 58 were the most common types in CC and high-grade precancerous lesions in Chengdu, southwestern China [20]. …”

Section: Introductionmentioning

confidence: 99%

Human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China

Guo

Wang²,

et al. 2017

Infect Agents Cancer

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BackgroundThe mortality of cervical cancer in Longnan is as high as 39/10 million, ranking first in China.MethodsBetween 2012 to 2016, 329 samples with cervicitis, cervical intraepithelial neoplasia grade 1 to 3 (CINI to III), and invasive squamous cell carcinoma (SCC) were collected. HPV genotypes were examined with a validated kit for 23 different HPV subtypes.ResultsCompared to cervicitis, the HPV positivity is significantly higher in CINI, CIN II/III, and SCC (38.60%, 74.60%, 87.50% and 89.05%, P < 0.001) and the positivity is also higher in SCC compared to CINI (P < 0.01). The most frequently detected genotypes were HPV16 in cervicitis, HPV16, 58 and 52 in CINI and CIN II/III, and HPV16, 58 and 18 in SCC groups. HPV16 positivity in cervicitis, CINI, CIN II/III, and SCC patients were 45.46%, 46.81%, 60.32% and 78.69%, respectively. Compared to cervicitis and CINI, the odds ratios (OR) for SCC in HPV16 positive patients were 2.96 (95% confidence interval [CI]: 1.09–8.00, P < 0.05) and 4.20 (95% confidence interval [CI]: 2.05–8.61, P < 0.001), respectively. In addition, the multiple infections in cervicitis, CINI, CINII/III and SCC group are 9.09%, 27.66%, 26.98% and 25.41% and HPV16 + 58 was the most common combinations.ConclusionThese findings highlight the key role of HPV16, 58, 52 and 18 in the development of CIN and SCC in Longnan women and a fully aware of regional differences in HPV genotype distribution are tasks for cervical cancer control and prevention.

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Epidemiology and genotype distribution of human papillomavirus (HPV) in women of Henan Province, China

Cited by 27 publications

References 25 publications

Prevalence and genotype distribution of human papillomavirus: implications for cancer screening and vaccination in Henan province, China

Prevalence and genotype distribution of human papillomavirus: implications for cancer screening and vaccination in Henan province, China

Type-Specific Identification of Genital Human Papillomavirus Infection in Women with Cytological Abnormality

Human papillomavirus genotypes associated with cervical precancerous lesions and cancer in the highest area of cervical cancer mortality, Longnan, China

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