Epidemiology and history of human parasitic diseases in Romania

Neghină, Adriana Maria; Marincu, Iosif; Iacobiciu, Ioan

doi:10.1007/s00436-011-2256-0

Cited by 27 publications

(21 citation statements)

References 29 publications

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“…Despite the recent detection of vector-competent phlebotomine sandfly species in Hungary, screening of indigenous dogs and wild canids gave up to date no evidence for Leishmania infections (Farkas et al 2011). Vector-competent Plebotomus perfiliewi have been identified in southern Romania but there are no current reports on authochthonous canine or human leishmaniosis available (Danesco 2008;Neghina et al 2011). Although treatment does not eliminate Leishmania spp.…”

Section: Leishmania Sppmentioning

confidence: 96%

Epidemiological aspects on vector-borne infections in stray and pet dogs from Romania and Hungary with focus on Babesia spp.

Hamel

Silaghi

Lescai³

et al. 2011

Parasitol Res

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Canine arthropod-borne infections are of major interest in small animal practice and have been widely investigated in Central and Western Europe. However, only limited epidemiological data are available from South-Eastern European countries, although diseases including babesiosis or dirofilariosis are widely recognised as important canine infections in these countries. A steadily increasing number of dogs imported from South-Eastern Europe into Germany require particular attention by small animal practitioners. In this study, a total of 216 dogs [29 local Romanian pet dogs presented at Salvavet Veterinary Clinic in Bucharest, Romania, and 187 imported stray dogs from Romania (n = 109) and Hungary (n = 78) into Germany] were screened by molecular biological, serological and haematological methods for canine arthropod-borne infections. Eleven different parasitic and bacterial vector-borne pathogens-Babesia canis canis, Babesia canis vogeli, Babesia gibsoni, Babesia felis-like, Hepatozoon canis, Leishmania spp., Dirofilaria immitis, Dirofilaria repens, Acanthocheilonema reconditum, Anaplasma phagocytophilum and Mycoplasma haemocanis-were detected. Fifty-six percent of the dogs were positive by direct methods. B. canis canis was the most prevalent pathogen in dogs imported to Germany (42.8%) and dogs submitted for clinical consultation in Bucharest (44.8%). Our data strongly suggest the introduction of an adjusted screening panel in dogs from South-East Europe in view of increasing importation of dogs into Germany.

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Section: Leishmania Sppmentioning

confidence: 96%

Epidemiological aspects on vector-borne infections in stray and pet dogs from Romania and Hungary with focus on Babesia spp.

Hamel

Silaghi

Lescai³

et al. 2011

Parasitol Res

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“…Albendazole (ABZ), a derivative of benzimidazoles, and its sulfoxide derivative, albendazole sulfoxide (ABZSX), are the most preferred drugs in the treatment of various parasitic diseases. These drugs are used as prophylaxis prior to surgery and cover a broad anthelmintic spectrum in inoperable cases because of their potent antiparasitic activities and relatively less side effects 1. Nevertheless, hydrophobicity is an important physicochemical parameter for the formulation of highly potent benzimidazoles.…”

Section: Introductionmentioning

confidence: 99%

Novel albendazole–chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats

et al. 2013

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To improve the treatment of helminthiasis, filariasis, and colorectal cancer, albendazole-associated chitosan nanoparticles (ABZ-CS-NPs) were prepared using the emulsion crosslinking volatile technique with contained sodium tripolyphosphate as the crosslinking agent and Poloxamer 188 as the auxiliary solvent. The structural characteristics of the NPs were determined using X-ray diffraction to analyze the interaction between CS and the drug. The NPs were then evaluated in terms of their physicochemical characteristics, drug release behavior, in vivo pharmacokinetic parameters, and biodistribution in animal studies. ABZ-loaded NPs with a uniformly spherical particle sizes (157.8 ± 2.82 nm) showed efficient drug loading, encapsulated efficiency, and high physical stability. The drug release from ABZ-CS-NPs was extended over several periods. Kinetic models were then fitted to determine the release mechanisms. ABZ and its metabolite albendazole sulfoxide (ABZSX) were analyzed in rats with mebendazole as the internal standard using reversed-phase high-performance liquid chromatography. Compared with the ABZ suspension groups, the relative bioavailability values of ABZ and ABZSX were 146.05 and 222.15%, respectively. In addition, the plasma concentration versus time curve is consistent with that of the two compartment models in the plasma concentration versus time curve. The results indicate that the ABZ-loaded NPs are promising novel ABZ candidates for passive diffusion in the treatment of hydatid cysts in the liver via oral administration.

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“…In Romania, a country found over time to be highly endemic for trichinellosis, the first human case was detected in 1868 (in a cadaver autopsy), and a small epidemic developed in 1874 in Jassy (situated in the region of Moldova) when six members of a Polish-German family consumed tainted pork sausages. Unfortunately, three of them died, causing panic in the population, especially when the larvae were observed under microscopy (Neghina et al 2011(Neghina et al , 2010. Other significant cases/epidemics occurred in Denmark , the Crépy-en-Valois region of France (1878), Spain (1900), and Czechoslovakia (1902-1903 (Blancou 2001).…”

Section: The Controversial Discoverymentioning

confidence: 96%

The roots of evil: the amazing history of trichinellosis and Trichinella parasites

et al. 2011

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This review aims to investigate, from a historical point of view, the roots of the Trichinella pathogens and the disease they produce, beginning from the times first recorded in the Bible and continuing until the scientific mysteries of the pathogen were finally unveiled. Our journey sheds light on "strange" epidemics developing before the discovery of the parasite and bearing a clinical similitude to trichinellosis; it follows the controversies that erupted after the nineteenth century discovery of the parasite and the subsequent official outbreaks, and then examines the pioneering methods used for its visualization. Finally, it tries to reveal the possible relationship of trichinellosis with the arts. Furthermore, it seems that the saga of the helminth, "destined to remain with us, both in nature and in the laboratory," will continue to haunt and fascinate scientists from both developing and developed countries, as they try to answer new questions about the parasite's "evil" nature.

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Epidemiology and history of human parasitic diseases in Romania

Cited by 27 publications

References 29 publications

Epidemiological aspects on vector-borne infections in stray and pet dogs from Romania and Hungary with focus on Babesia spp.

Epidemiological aspects on vector-borne infections in stray and pet dogs from Romania and Hungary with focus on Babesia spp.

Novel albendazole–chitosan nanoparticles for intestinal absorption enhancement and hepatic targeting improvement in rats

The roots of evil: the amazing history of trichinellosis and Trichinella parasites

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