Epidemiology and laboratory diagnosis of fungal corneal ulcer in the Sundarban Region of West Bengal, eastern India

Bandyopadhyay, Sanjoy; Das, Dilip Kumar; Mondal, Kanchan Kumar; Ghanta, A K; Purkrit, S K; Bhasrar, R

doi:10.3126/nepjoph.v4i1.5847

Cited by 14 publications

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“…[1,2] These infections are caused by fungal penetration of a compromized corneal epithelium, typically following corneal trauma with vegetable matter. [3] While the prevalence of fungal keratitis is relatively high in tropical regions such as South India, Ghana, and China, [4][5][6][7][8][9] it is generally much lower in temperate regions such as the UK and the Northern United States. [4,10,11] However, there have been numerous case reports of fungal keratitis associated with both therapeutic and daily soft contact lens wear.…”

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confidence: 99%

In vitrouptake and release of natamycin Dex-b-PLA nanoparticles from model contact lens materials

Phan¹,

Subbaraman²,

Liu³

et al. 2013

Journal of Biomaterials Science, Polymer Edition

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confidence: 99%

In vitrouptake and release of natamycin Dex-b-PLA nanoparticles from model contact lens materials

Phan¹,

Subbaraman²,

Liu³

et al. 2013

Journal of Biomaterials Science, Polymer Edition

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“…20 Various studies revealed the utility of KOH preparation in fungal corneal ulcers. 8,18,20,21,22 The sensitivity of KOH preparation has been found to be variable ranging between 33-94% as reported by various studies. The sensitivity and specificity of KOH preparation in our study was 45.45% and 75% respectively.…”

Section: Discussionmentioning

confidence: 94%

“…This was much different from other reported series. 20,21 In a study by Bandyopadhyay S et al, the sensitivity was 98.3% and specificity was 98.5%. Fungal Hyphae were seen by wet mount preparation in 80.9% cases and culture growth present in 88% cases as reported by V Sharma et al 20 The fungal culture positivity was 41% in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Fungal Hyphae were seen by wet mount preparation in 80.9% cases and culture growth present in 88% cases as reported by V Sharma et al 20 The fungal culture positivity was 41% in our study. Bandyopadhyay et al 21 reported that 72.9% corneal ulcers were culture positive. This figure agrees with previous studies in West Bengal, Chennai and Ghana.…”

Section: Discussionmentioning

confidence: 99%

“…This figure agrees with previous studies in West Bengal, Chennai and Ghana. 6,21 Studies done in tropical countries like Bangladesh and Nepal reported the incidence from 17% to 40%. 16 More than 70 species of fungi have been reported to cause mycotic corneal ulcers.…”

Section: Discussionmentioning

confidence: 99%

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Fungal Corneal Ulcers: A Prospective Study on the Causative Fungus and the Response to the Present Treatment Protocol

Jisha¹,

Sreekumari²,

Rajesh³

et al. 2016

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BACKGROUNDFungal keratitis is a significant cause of ocular morbidity and unilateral blindness worldwide. The incidence varies with various geographical location and is more common in tropical countries. They are the predominant type of infective corneal ulcers in South India. Identifying the fungal spectrum in each geographical location may help to choose the initial treatment. Aim of the study was to identify spectrum of fungi, to assess the response to the standard treatment given and to find out the sensitivity and specificity of KOH preparation in clinically diagnosed fungal corneal ulcers in patients attending a tertiary care centre in Kerala.

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Fungal Keratitis in North India: Spectrum of Agents, Risk Factors and Treatment

et al. 2016

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To assess the prevalence of fungal keratitis, we conducted a retrospective study over 7 years (2005 through 2011) at a tertiary care center in North India. Effort has been made to analyze the disease burden, spectrum of agents and treatment history. The findings were compared with an earlier study at the same center for any change in the epidemiology of the disease. Microbiology records were screened at the Postgraduate Institute of Medical Education and Research, Chandigarh, India, to identify fungal keratitis cases, and available clinical records of those cases were analyzed. Of 2459 clinically suspected fungal keratitis cases, 765 (31 %) cases were direct microscopy confirmed. Of these microscopy-confirmed cases, fungi were isolated in 393 (51.4 %), with Aspergillus spp. ranked top (n = 187, 47.6 %), followed by melanized fungi (n = 86, 21.9 %) and Fusarium spp. (n = 64, 16 %). A male predominance of 78.7 % was noted with a peak in the incidence of fungal keratitis during post-monsoon season (September to November). A delay in diagnosis was significantly associated (p < 0.001) with keratitis cases due to melanized fungi. In comparison with an earlier study, higher isolation of melanized fungi was noted with a widening of the spectrum of agents identified. Thus, fungal keratitis due to Aspergillus spp. remains a serious ocular illness among the active male population in North India with relative rise of keratitis due to melanized fungi. The spectrum of agents causing fungal keratitis has broadened with many rare fungi that are implicated.

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Epidemiology and laboratory diagnosis of fungal corneal ulcer in the Sundarban Region of West Bengal, eastern India

Abstract: Introduction: Corneal ulcers are the second most-common cause of preventable blindness after cataract in tropical developing countries. Fungal corneal ulcers constitute 30 to 62 % of the total microbial culture-positive corneal ulcers.

Cited by 14 publications

References 0 publications

In vitrouptake and release of natamycin Dex-b-PLA nanoparticles from model contact lens materials

In vitrouptake and release of natamycin Dex-b-PLA nanoparticles from model contact lens materials

Fungal Corneal Ulcers: A Prospective Study on the Causative Fungus and the Response to the Present Treatment Protocol

Fungal Keratitis in North India: Spectrum of Agents, Risk Factors and Treatment

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