Epidemiology and molecular characteristics of community-associated methicillin-resistant and methicillin-susceptible Staphylococcus aureus from skin/soft tissue infections in a children's hospital in Beijing, China

High prevalence of ST121 in community-associated methicillin-susceptible Staphylococcus aureus lineages responsible for skin and soft tissue infections in Portuguese children

“…Recently, a mechanism of PVL-induced acute lung injury and lung inflammation in rabbit models resolved the controversy about the role of PVL as a key factor in S. aureus infection [37]. In our study, isolates producing PVL or g-hemolysin were mainly associated to cutaneous abscesses (p=0.003 and p=0.000, respectively), as has already been reported in recent studies in children infections [38,39]. Conversely, the production of β-hemolysin, ETA, or ETB seemed to be associated with cellulitis (p=0.010, p=0.003, and p=0.038, respectively) (data not shown).…”

Antimicrobial Resistance and Molecular Characteristics of Methicillin-Resistant <i>Staphylococcus aureus</i> Isolates from Child Patients of High-Risk Wards in Shenzhen, China

“…spa type t002 is also common in Israel (28), while spa type t044 is widespread in European countries (29). Our results indicate that t437 was the predominant spa type among MRSA isolates from Shenzhen, south China, and accounts for 57.1 of all MRSA isolates, consistent with a previous study of isolates collected in Beijing, northern China (30).…”

Characterisation of virulence genes in methicillin susceptible and resistant Staphylococcus aureus isolates from a paediatric population in a university hospital of Medellín, Colombia

“…These results agree with those of studies that found lower frequencies of the genes encoding PVL in MSSA clinical isolates (Kuehnert et al 2006), but contrast with data reported from the Czech Republic, where it was found that the lukS/F-PV, tst and sec genes were more frequent in MSSA isolates and enterotoxins genes sea, seb, sed and eta were most prevalent in MRSA strains (Sila et al 2009). Also, in this study, lukS/F-PV were more frequently observed in SCCmec IVc isolates (94%), but they were not restricted to this cassette type and they were also present in SCCmec types I, IVa and V. Other studies conducted in China (Wu et al 2010) and in USA (Abdel-Haq et al 2009) that have evaluated the epidemiological and molecular features of MRSA and MSSA isolates from children found that the most frequent SCCmec type was IVa and all of these strains carried the lukS/F-PV genes. Also, similar to our findings, results of a study conducted in Lebanon revealed that the PVL genes were present mainly in SCCmec IVc isolates (Tokajian et al 2010).…”

“…aureus and in particular CA-MRSA, has become a successful pathogen within the paediatric population. A dramatic increase in community-MRSA infections has been reported in healthy children (Herold et al 1998, Bocchini et al 2006, Stankovic & Mahajan 2006, Faden et al 2007, Baker 2010, Wu et al 2010). …”