Epidemiology and molecular characterization of influenza viruses in Burkina Faso, sub‐Saharan Africa

Sanou, Armel M.; Wandaogo, Sampoko Carine M.; Poda, Armel; Tamini, Laure; Kyere, Anselme E.; Sagna, Tani; Ouédraogo, M.; Pauly, Maude; Hübschen, Judith M.; Tarnagda, Zékiba; Snoeck, Chantal J.

doi:10.1111/irv.12539

Cited by 12 publications

(19 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The two sequences collected in 2014 belonged to clade 6C represented by A/Dakar/02/2014 while all sequences collected between 2015 and 2016 belonged to clade 6B represented by A/South Africa/3626/2013. Several other studies have shown the same temporal circulation of these two clades [22, 23] while others showed the presence of viruses of clade 6B in the 2014 season [24–26]. The 2014 virus strains differed from the vaccine strain by acquiring an amino acid substitution on antigenic site Ca (K142R).…”

Section: Discussionmentioning

confidence: 99%

Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons

Monamele¹,

Njifon²,

Vernet³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

In 2009, Influenza A(H1N1)pdm09 caused the first influenza pandemic of the 21st century with high mortality rates of about 284 500 deaths. This virus, however, continues to circulate as a seasonal influenza virus and to cause illness and deaths worldwide. In this study, we describe the genetic diversity of A(H1N1)pdm09 viruses collected between 2014 and 2016 in Cameroon. Three gene segments (HA, NA and M) of Cameroon strains were studied. The phylogenetic tree of the coding nucleotide sequences was generated by MEGA version 6.0 using a Maximum Likelihood method. The NA and M protein coding sequences were analyzed for the reported genetic markers of resistance against neuraminidase inhibitors and adamantanes, while predicted vaccine efficacy was estimated using the Pepitope method. Overall 39 strains were obtained. Phylogenetic analysis of the HA gene of influenza A(H1N1)pdm09 showed that Cameroon strains belonged to two major clades. The 2014 Cameroon sequences belonged to clade 6C while all sequences collected between 2015 and 2016 belonged to clade 6B. Majority of the samples had some mutations in the NA gene notably: I117M, N248D, and N369K while the amantadine-resistant M mutant, S31N, was found to be absent only in the two sequences collected in 2014. Overall, A/California/07/2009 vaccine strain showed a predicted vaccine efficacy of 24.55% to 35.77% against Cameroon A(H1N1)pdm09 strains circulating between 2014 and 2016. Our findings confirms the fast evolution of A(H1N1)pdm09 since its first introduction and highlights on the importance of influenza vaccine in reducing the burden caused by influenza in the community.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons

Monamele¹,

Njifon²,

Vernet³

et al. 2019

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…In Burkina Faso, a country in the semiarid Sahel and Savanna zones of West Africa, malaria transmission remains high, with marked seasonality in the rainy season [9e11]. Influenza virus has been reported to circulate in Burkina Faso [12,13], but its importance and that of other viral respiratory infections in the aetiology of nonmalaria fever remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Aetiology of acute febrile illness in children in a high malaria transmission area in West Africa

Kaboré

Post

Lompo

et al. 2021

Clinical Microbiology and Infection

View full text Add to dashboard Cite

Objectives: Areas with declining malaria transmission in sub-Saharan Africa have recently witnessed important changes in the aetiology of childhood acute febrile illness (AFI). We describe the aetiology of AFI in a high malaria transmission area in rural Burkina Faso. Methods: In a prospective hospital-based diagnostic study, children aged 3 months to 15 years with AFI were recruited and assessed using a systematic diagnostic protocol, including blood cultures, whole blood PCR on a selection of bacterial pathogens, malaria diagnostics and a multiplex PCR on nasopharyngeal swabs targeting 21 viral and 4 bacterial respiratory pathogens. Results: A total of 589 children with AFI were enrolled from whom an infectious disease was considered in 575 cases. Acute respiratory tract infections, malaria and invasive bacterial infections (IBI) accounted for 179 (31.1%), 175 (30.4%) and 75 (13%) of AFI cases respectively; 16 (21.3%) of IBI cases also had malarial parasitaemia. A viral pathogen was demonstrated from the nasopharynx in 157 children (90.7%) with respiratory tract symptoms. Of all children with viral respiratory tract infections, 154 (92.4% received antibiotics, whereas no antibiotic was provided in 13 (17%) of IBI cases. Conclusions: Viral respiratory infections are a common cause of childhood AFI in high malaria transmission areas, next to malaria and IBI. These findings highlight the importance of interventions to improve targeted treatment with antimicrobials. Most patients with viral infections received antibiotics unnecessarily, while a considerable number with IBI did not receive antibiotics.

show abstract

“…Similarly, seven cases of the SARI were due to IAV infection, five were because of IBV infection, two were due to the A(H1N1)pdm09 virus, and another five were due to the H3N2 virus infection. This study reported that different types and strains of influenza viruses were responsible for inflicting ILI and SARI among children in Burkina Faso [93].…”

Section: Burkina Fasomentioning

confidence: 85%

Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

et al. 2020

View full text Add to dashboard Cite

Emerging and re-emerging viral diseases are of great public health concern. The recent emergence of Severe Acute Respiratory Syndrome (SARS) related coronavirus (SARS-CoV-2) in December 2019 in China, which causes COVID-19 disease in humans, and its current spread to several countries, leading to the first pandemic in history to be caused by a coronavirus, highlights the significance of zoonotic viral diseases. Rift Valley fever, rabies, West Nile, chikungunya, dengue, yellow fever, Crimean-Congo hemorrhagic fever, Ebola, and influenza viruses among many other viruses have been reported from different African countries. The paucity of information, lack of knowledge, limited resources, and climate change, coupled with cultural traditions make the African continent a hotspot for vector-borne and zoonotic viral diseases, which may spread globally. Currently, there is no information available on the status of virus diseases in Africa. This systematic review highlights the available information about viral diseases, including zoonotic and vector-borne diseases, reported in Africa. The findings will help us understand the trend of emerging and re-emerging virus diseases within the African continent. The findings recommend active surveillance of viral diseases and strict implementation of One Health measures in Africa to improve human public health and reduce the possibility of potential pandemics due to zoonotic viruses.

show abstract

Epidemiology and molecular characterization of influenza viruses in Burkina Faso, sub‐Saharan Africa

Cited by 12 publications

References 38 publications

Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons

Molecular characterization of influenza A(H1N1)pdm09 in Cameroon during the 2014-2016 influenza seasons

Aetiology of acute febrile illness in children in a high malaria transmission area in West Africa

Systematic Review of Important Viral Diseases in Africa in Light of the ‘One Health’ Concept

Contact Info

Product

Resources

About