2011
DOI: 10.1111/j.1365-2125.2010.03774.x
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Epidemiology and risk factors for drug allergy

Abstract: The aim of this review was to describe the current evidence-based knowledge of the epidemiology, prevalence, incidence, risk factors and genetic associations of drug allergy. Articles published between 1966 and 2010 were identified in MEDLINE using the key words adult, adverse drug reaction reporting systems, age factors, anaphylactoid, anaphylaxis, anaesthetics, antibiotics, child, drug allergy, drug eruptions, ethnic groups, hypersensitivity, neuromuscular depolarizing agents, neuromuscular nondepolarizin… Show more

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Cited by 308 publications
(257 citation statements)
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“…A higher reporting rate of ADR by females could be another factor contributing to such pattern [25]. On the other hand, a higher proportion of females experiencing an adverse reaction in our study may confirm results of other studies where a higher incidence of hypersensitivity reaction in females compared to males was found [26,27]. Nevertheless, this finding does not allow conclusions regarding the role of those characteristics as risk factors although they are further discussed in the literature.…”
Section: Suspect Herbalssupporting
confidence: 74%
“…A higher reporting rate of ADR by females could be another factor contributing to such pattern [25]. On the other hand, a higher proportion of females experiencing an adverse reaction in our study may confirm results of other studies where a higher incidence of hypersensitivity reaction in females compared to males was found [26,27]. Nevertheless, this finding does not allow conclusions regarding the role of those characteristics as risk factors although they are further discussed in the literature.…”
Section: Suspect Herbalssupporting
confidence: 74%
“…This is roughly similar to studies from other parts of the world. 2,8 Previous local studies have reported an incidence of 0.86%. 9 The low prevalence in this study may be attributed to the possibility that mild cases of ACDR not requiring dermatology consultation may not have been referred and hence not captured in this study.…”
Section: Discussionmentioning
confidence: 99%
“…Drug hypersensitivity reactions can lead to significant morbidity or death in affected individuals or deprive patients of access to drugs that would provide therapeutic benefit. The clinical manifestations of drug hypersensitivity can fall anywhere along a broad spectrum ranging in severity from mild and fully reversible upon drug withdrawal to severe (including death) and may involve either single-or multi-organ systems (Thong & Tan, 2011). It is rare for standard toxicity studies in laboratory animals to uncover potential hypersensitivity liabilities.…”
Section: Introductionmentioning
confidence: 99%