Epidemiology and risk-stratification of NAFLD-associated HCC

Abstract

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Therapeutic Values of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma: Facts and Hopes

“…ing cause of HCC in the absence of cirrhosis [83]. Similarly, the frequency of CD11b+Gr1+ MDSCs in the liver of NAFLD mice was significantly higher than that of the control group, which may partly recruit to the NAFLD liver through the CCL2-CCR2 pathway and expanded through CSF stimulation.…”

“…Compared with alcoholic steatosis patients or normal people, ALC patients showed higher levels of PMN-MDSCs in peripheral blood and liver, and stronger inhibitory activity against NK cells [82]. NAFLD is the fastest-rising cause of HCC globally and the leading cause of HCC in the absence of cirrhosis [83]. Similarly, the frequency of CD11b+Gr1+ MDSCs in the liver of NAFLD mice was significantly higher than that of the control group, which may partly recruit to the NAFLD liver through the CCL2-CCR2 pathway and expanded through CSF stimulation [84].…”

Advances in RNA Epigenetic Modifications in Hepatocellular Carcinoma and Potential Targeted Intervention Strategies

“…The main reason for the high mortality/poor prognosis of HCC is the malignant growth, invasion, metastasis and refractoriness of the tumor (Ioannou, 2021). Despite the ongoing development of medical technology and the increasing abundance of treatment methods, HCC is still one of the urgent problems to be solved in the era of precision medicine due to the unexplained molecular mechanism of its carcinogenesis and development, lack of ideal therapeutic targets and targeted intervention strategies (Jiri et al, 2020).…”

The Role of Notch Signaling Pathway in Non-Alcoholic Fatty Liver Disease

“…Although hepatitis B virus (HBV) infection has been the prominent risk factor of HCC, NAFLD has become the most rapidly growing driver of HCC in many countries ( Younossi et al, 2019 ; Hester et al, 2020 ). The incidence in patients with NAFLD-related HCC increases with the histological stage, which is highest in patients with NAFLD-cirrhosis ( Ioannou, 2021 ).…”