Epidemiology of asthma in schoolchildren in Portuguese speaking regions

Pinto, José Rosado; Almeida, Mário Morais de

doi:10.1016/j.allerg.2005.07.011

Cited by 3 publications

(3 citation statements)

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“…In Portugal, 7.83% of the population is affected by clinical asthma and 8.72% by wheezing symptoms [ 5 ]. Within Portugal, the island of Madeira has a high prevalence of the disease, as active asthma (presence of symptoms during the last 12 months) affects 14.6%, and atopy (positive reaction to skin prick tests (SPT) to common aeroallergens and the presence of specific IgE) affects 54% of the population [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Given the high prevalence of asthma in the Madeira population [ 6 ], determining the population’s genetic background is an essential first step towards understanding the mechanisms of the disease. In previous work [ 7 ] we showed that both IL4-590 and IL4-RP2 are useful genetic markers to detect asthma predisposition in the Madeira population.…”

Section: Introductionmentioning

confidence: 99%

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Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

Berenguer¹,

Fernandes²,

Oliveira³

et al. 2014

Biol Res

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BackgroundAsthma is a complex disease influenced by multiple genetic and environmental factors. While Madeira has the highest prevalence of asthma in Portugal (14.6%), the effect of both genetic and environmental factors in this population has never been assessed. We categorized 98 asthma patients according to the Global Initiative for Asthma (GINA) guidelines, established their sensitization profile, and measured their forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) indexes. Selected single nucleotide polymorphisms (SNPs) were analysed as potential markers for asthma susceptibility and severity in the interleukin 4 (IL4), interleukin 13 (IL13), beta-2-adrenergic receptor (ADRB2), a disintegrin and metalloprotease 33 (ADAM33), gasdermin-like (GSDML) and the signal transducer and activator of transcription 6 (STAT6) genes comparatively to a population reference set.ResultsAlthough mites are the major source of allergic sensitization, no significant difference was found amongst asthma severity categories. IL4-590*CT/TT and IL4-RP2*253183/183183 were found to predict the risk (2-fold) and severity (3 to 4-fold) of asthma and were associated with a lower FEV1 index. ADRB2-c.16*AG is a risk factor (3.5-fold), while genotype GSDML-236*TT was protective (4-fold) for moderate-severe asthma. ADAM33-V4*C was associated to asthma and mild asthma by the transmission disequilibrium test (TDT). Finally, ADAM33-V4*CC and STAT6-21*TT were associated with higher sensitization (mean wheal size ≥10 mm) to house dust (1.4-fold) and storage mite (7.8-fold).ConclusionIn Madeira, IL4-590C/T, IL4-RP2 253/183, GSDML-236C/T and ADAM33-V4C/G SNPs are important risk factors for asthma susceptibility and severity, with implications for asthma healthcare management.Electronic supplementary materialThe online version of this article (doi:10.1186/0717-6287-47-40) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

Berenguer¹,

Fernandes²,

Oliveira³

et al. 2014

Biol Res

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“…In recent decades tourism has supplanted the production of salt as the main activity (PINTO; ALMEIDA, 2005). During this period the population has increased greatly, due basically to the development of modern tourist resorts, based mainly on the town of Santa Maria on the southern tip of the island which has become the main tourist centre of the archipelago.…”

Section: Study Areamentioning

confidence: 99%

Stakeholder perceptions of decision-making process on marine biodiversity conservation on sal island (Cape Verde)

Ramos¹,

Oliveira²,

Santos³

2011

Braz. j. oceanogr.

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A B S T R A C TIn the Sal Island (Cape Verde) there is a growing involvement, will and investment in the creation of tourism synergies. However, much of the economic potential of the island can be found submerged in the sea: it is its intrinsic 'biodiversity'. Due to this fact, and in order to balance environmental safety and human pressure, it has been developed a strategy addressing both diving and fishing purposes. That strategy includes the deployment of several artificial reefs (ARs) around the island. In order to allocate demand for diving and fishing purposes, we have developed a socio-economic research approach addressing the theme of biodiversity and reefs (both natural and artificial) and collected expectations from AR users by means of an inquiry method. It is hypothesized a project where some management measures are proposed aiming marine biodiversity conservation. Using the methodology named as analytic hierarchy process (AHP) it was scrutinized stakeholders' perception on the best practice for marine biodiversity conservation in the Sal Island. The results showed that to submerge obsolete structures in rocky or mixed areas have a high potential, but does not gathers consensuality. As an overall conclusion, it seems that limitation of activities is the preferred management option to consider in the future. R E S U M ONa Ilha do Sal (Cabo Verde) existe um crescente envolvimento, vontade e investimento na criação de sinergias turísticas. Contudo, muito do potencial económico da ilha está submerso -a biodiversidade marinha. Devido a este facto, e tendo em vista promover a sustentabilidade ambiental associada ao eco-turismo, vem sendo desenvolvida uma estratégia direccionada, quer ao mergulho, quer à pesca. Esta estratégia inclui a implantação de vários recifes artificiais (RA) na Baía de Santa Maria. De modo a alocar a procura para propósitos como o mergulho e a pesca, desenvolvemos um plano de pesquisa socio-económica relativo ao tema da biodiversidade e recifes (naturais e artificiais) e recolhemos as expectativas dos utilizadores de RAs. Assim, foi elaborado um projecto teórico cujo objectivo é a conservação da biodiversidade marinha, no qual são propostas algumas medidas de gestão. Através da utilização do método designado por processo analítico hierárquico (PAH) foi escrutinada a percepção dos utilizadores sobre as melhores práticas para a conservação da biodiversidade marinha na Ilha do Sal. Os resultados mostraram que o afundamento de estruturas obsoletas em áreas rochosas ou mistas parece ter um grande potencial, mas não é consensual. Em conclusão, a limitação de actividades de mergulho afigura-se como uma opção a considerar futuramente.Descriptors: Marine biodiversity conservation, artificial reef project, Sal Island (Cape Verde), underwater tourism, Analytic hierarchy process (AHP). Descritores: Conservação da biodiversidade marinha, Projeto de recifes artificiais, Ilha do Sal (Cabo Verde), Eco-turismo subaquático, Processo analítico hierárquico (PAH).

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Asthma knowledge, subjective assessment of severity and symptom perception in parents of children with asthma

Silva

Barros

2013

Journal of Asthma

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Portuguese parents revealed a tendency to overestimate their child's level of asthma control and a low level of asthma knowledge. Parents' education, psychological disturbance and time since diagnosis were associated with asthma knowledge. Parents' knowledge was not related to the child's asthma outcomes or to their subjective evaluation of asthma severity or symptoms reports. Parents' asthma knowledge deficits, underreporting of symptoms and underestimation of asthma severity, may affect parent-provider communication and impede asthma control.

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Epidemiology of asthma in schoolchildren in Portuguese speaking regions

Cited by 3 publications

References 12 publications

Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

Genetic polymorphisms and asthma: findings from a case–control study in the Madeira island population

Stakeholder perceptions of decision-making process on marine biodiversity conservation on sal island (Cape Verde)

Asthma knowledge, subjective assessment of severity and symptom perception in parents of children with asthma

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