Epidemiology of autoimmune diseases in Denmark

Eaton, William W.; Rose, Noel R.; Kalaydjian, Amanda; Pedersen, Marianne Bruus; Mortensen, Preben Bo

doi:10.1016/j.jaut.2007.05.002

Cited by 378 publications

(333 citation statements)

References 37 publications

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“…Thirty AID were identified according to ICD-8 and ICD-10 and are listed in Table 1. More details on AID in Denmark are available from recent publications [32].…”

Section: Methodsmentioning

confidence: 99%

Pregnancy and the risk of autoimmune disease

O’Donoghue

2011

Chimerism

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Autoimmune diseases (AID) predominantly affect women of reproductive age. While basic molecular studies have implicated persisting fetal cells in the mother in some AID, supportive epidemiological evidence is limited. We investigated the effect of vaginal delivery, caesarean section (CS) and induced abortion on the risk of subsequent maternal AID. Using the Danish Civil Registration System (CRS) we identified women who were born between 1960 and1992. We performed data linkage between the CRS other Danish national registers to identify women who had a pregnancy and those who developed AID. Women were categorised into 4 groups; nulligravida (control group), women who had 1st child by vaginal delivery, whose 1st delivery was by CS and who had abortions. Log-linear Poisson regression with person-years was used for data analysis adjusting for several potential confounders. There were 1,035,639 women aged .14 years and 25,570 developed AID: 43.4% nulligravida, 44.3% had their first pregnancy delivered vaginally, 7.6% CS and 4.1% abortions. The risk of AID was significantly higher in the 1st year after vaginal delivery (RR = 1.1[1.0, 1.2]) and CS (RR = 1.3[1.1, 1.5]) but significantly lower in the 1st year following abortion (RR = 0.7[0.6, 0.9]). These results suggest an association between pregnancy and the risk of subsequent maternal AID. Increased risks of AID after CS may be explained by amplified fetal cell traffic at delivery, while decreased risks after abortion may be due to the transfer of more primitive fetal stem cells. The increased risk of AID in the first year after delivery may also be related to greater testing during pregnancy.

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“…Thirty AID were identified according to ICD-8 and ICD-10 and are listed in Table 1. More details on AID in Denmark are available from recent publications [32].…”

Section: Methodsmentioning

confidence: 99%

Pregnancy and the risk of autoimmune disease

O’Donoghue

2011

Chimerism

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“…IMIDs involve an immune response that is inappropriate or excessive and is caused or accompanied by a dysregulation of the normal cytokine milieu. They also cause acute and chronic inflammatory injury in any organ system leading to end organ damage (9,10,14,34,43). Patients were seen via a multidisciplinary approach, consisting of consultations with both a cardiologist (R.D.…”

Section: Study Population (I) Dcm Subjectsmentioning

confidence: 99%

Differences in Virus Prevalence and Load in the Hearts of Patients with Idiopathic Dilated Cardiomyopathy with and without Immune-Mediated Inflammatory Diseases

Dennert¹,

Paassen²,

Wolffs³

et al. 2012

Clin. Vaccine Immunol.

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dInfections with cardiotrophic viruses and immune-mediated responses against the heart have been suggested to play a dominant role in the pathogenesis of idiopathic dilated cardiomyopathy (DCM). Furthermore, immune-mediated inflammatory diseases (IMIDs) may result in DCM. It has not previously been assessed whether DCM patients with and without an IMID have different prevalences and quantities of cardiotrophic viruses in the heart. Therefore, we compared the profiles of cardiotrophic viruses in heart tissue of DCM patients with and without an IMID. Serum and myocardial tissue samples were obtained from 159 consecutive patients with DCM and 20 controls. Patients were subdivided into three groups, the first two based on the presence (n ‫؍‬ 34) or absence (n ‫؍‬ 125) of an IMID and the third being a control group. The parvovirus B19 virus genome was detected in equal quantities in the non-IMID DCM patients (100/125) and the control group (15/20) but in lower quantities in the IMID patients (21/34, P ‫؍‬ 0.02). Both the non-IMID and IMID DCM patients demonstrated increased myocardial inflammation compared to controls: 12.5 ؎ 1.8 and 14.0 ؎ 3.2 CD45-positive inflammatory cells, respectively, versus 5.1 ؎ 0.7 for the controls (P < 0.05 for both). Importantly, significantly higher parvovirus B19 copy numbers could be amplified in non-IMID than in IMID patients (561 ؎ 97 versus 191 ؎ 92 copies/g DNA, P < 0.001) and control subjects (103 ؎ 47 copies/g DNA, P < 0.001). The present study shows decreased parvovirus B19 prevalence and copy numbers in hearts of DCM patients with an IMID compared to those without an IMID. These findings may suggest that DCM patients with an IMID have a different pathophysiologic mechanism from that which is present in the virus-induced form of DCM.

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“…AIHA occurs due to warm or cold autoantibody types and, rarely, mixed type [13,14]. In a recent population-based study [15], the incidence was found to be 0.8/100,000/year, but the prevalence is found to be 17/100,000 [16]. Warm antibody autoimmune hemolytic anemia (wAIHA) is the most common of the autoimmune hemolytic diseases [17].…”

Section: Introductionmentioning

confidence: 99%

Warm Autoimmune Hemolytic Anemia: Clinical Profile and Management

Sudulagunta¹,

Kumbhat

Sodalagunta

et al. 2017

J Hematol

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Background: Autoimmune hemolytic anemia (AIHA) is a rare autoimmune disease in which autoantibodies target red blood cells leading to marked decrease in their lifespan. The classification of AIHA is based on the immunochemical properties of the RBC autoantibody. Warm antibody AIHA (wAIHA) accounts for 75-80% of all adult AIHA cases. The treatment of wAIHA is mainly corticosteroids. Our retrospective study aimed to study the clinical profile and management of wAIHA.

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Epidemiology of autoimmune diseases in Denmark

Cited by 378 publications

References 37 publications

Pregnancy and the risk of autoimmune disease

Pregnancy and the risk of autoimmune disease

Differences in Virus Prevalence and Load in the Hearts of Patients with Idiopathic Dilated Cardiomyopathy with and without Immune-Mediated Inflammatory Diseases

Warm Autoimmune Hemolytic Anemia: Clinical Profile and Management

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