Epidemiology of Benign Breast Disease, with Special Attention to Histologic Types

Goehring, Catherine; Morabia, Alfredo

doi:10.1093/oxfordjournals.epirev.a017960

Cited by 116 publications

(108 citation statements)

References 97 publications

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“…Most earlier studies of BBD have focused on the risks of breast cancer associated with a few specific lesions (1,(15)(16)(17)(18), for the most part atypical hyperplasias (2-4, 13, 19). There is very limited information with regard to the issue of lesion multiplicity in BBD biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…Epidemiological investigations indicate that more than 50% of all women will have benign breast disease (BBD) beyond age 20 (1). It has long been recognized that some BBD lesions will eventually develop into breast cancer (2-6).…”

Section: Introductionmentioning

confidence: 99%

“…Dupont and Page (7) examined 10,366 breast biopsies and classified BBD lesions into three pathologic categories: nonproliferative, proliferative without atypia, and atypical hyperplasia. The risk of breast cancer has been associated with specific histopathologic characteristics of BBD (1,4,(8)(9)(10)(11)). An increased cancer risk was found in women with proliferative lesions without atypia or with atypical hyperplasia (6,7,(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

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Benign breast disease heterogeneity: association with histopathology, age, and ethnicity

Cheng

Qiu

Raju

et al. 2007

Breast Cancer Res Treat

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Benign breast biopsies with concurrent multiple benign lesions with different histopathologic diagnoses were termed heterogeneous benign breast disease (HBBD). Multiplicity of benign breast disease (BBD) lesions in a biopsy is a risk factor for progression to breast cancer (BC). Elucidation of the biological characteristics and clinical implications of HBBD may also be relevant to the refinement of risks for BC in women with a BBD diagnosis. In this study, we investigated the association of HBBD with histopathology, age, and ethnicity. A cohort of 4,341 women, 1,208 African Americans and 3,133 Caucasians, diagnosed with BBD, was identified after examination of an excisional breast biopsy. BBD biopsies were categorized as nonproliferative (NP, low risk or risk 1 lesions), proliferative without atypia (P, intermediate risk or risk 2 lesions), and proliferative with atypia (AH, high risk or risk 3 lesions). A BBD biopsy with only a single BBD lesion was termed simple BBD (SBBD). BBD biopsies with multiple lesions were further classified as single level HBBD (SL-HBBD) if the concurrent lesions were within the same risk level, or as multiple level HBBD (ML-HBBD) if lesions fell into more than one risk group. In this cohort, 69% of women with a BBD diagnosis fit the HBBD criteria. Among women with HBBD, ML-HBBD was almost three times more prevalent than SL-HBBD and was significantly more likely to be composed of risk 2 and risk 3 lesions. The likelihood of HBBD was 57% higher in Caucasian American women than in African American women with BBD (OR 1.57; 95% CI 1.37, 1.81). The average lesion number in HBBD was directly proportional to increasing lesion risk (p < 0.001). Compared to women with risk 1 lesions, the likelihood of HBBD was 5.59 (95% CI 4.85 to 6.44) and 17.0 (95% CI 10.2 to 28.5) times higher when risk 2 and risk 3 lesions, respectively, were present. Women in the age range of 46-55 years and >55 years had a 3.12 (95% CI 2.59, 3.75) and a 2.28 (95% CI 1.94, 2.68) fold higher likelihood of HBBD compared to those ≤45 years. Significant interaction was found between concurrent lesion levels and age (p < 0.01). The likelihood of HBBD was considerably higher across all age groups for risk 3 lesions. Compared to the reference (risk 1, age ≤45), the likelihood of HBBD for risk 2 lesions was 4.4 times greater (95% CI 3.70, 5.33) in women ≤45 years, but that likelihood increased to 17.6 (95% CI 12.8, 24.2) and 13.4 (95% CI 10.1, 17.9) times in women of 46-55 and >55 years, respectively. HBBD is more prevalent in Caucasian American women than in African American women. Women with higher risk BBD lesions are more likely to have HBBD. Lesion

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Benign breast disease heterogeneity: association with histopathology, age, and ethnicity

Cheng

Qiu

Raju

et al. 2007

Breast Cancer Res Treat

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“…[8] Benign breast lesions deserve attention because of their high incidence, their impact on women's life and due to cancerous potential of some histological types. [9] Clinically, palpable lump is the commonest presentation followed by nipple discharge and pain along with other symptoms. [10] Many countries performing breast cancer screening programs aimed at detecting early disease in asymptomatic women.…”

Section: Introductionmentioning

confidence: 99%

Correlation of Histopathological Study of Breast Lesions with cytology and mammography as a measure of internal quality and diagnostic accuracy

Mulka

Kotasthane

Dhaka

et al. 2017

APALM

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Background: Breast cancer is the one of the leading causes death in women. Triple test approach has been widely accepted in asymptomatic women for the preoperative diagnosis of the breast lesions. Triple test includes clinical examination, mammography and Fine Needle Aspiration Cytology (FNAC) to differentiate between neoplastic and non-neoplastic lesions, histopathological confirmation being the gold standard for neoplasticlesions and best management plan for the patient.The aim was to study the histopathological spectrum of breast lesions and correlate the cytological and radiological findings with histopathological examination and to determine sensitivity, specificity and diagnostic accuracy of FNACand mammography in the diagnosis of the breast lesions. Methods:The study comprised of 552 casesofhistopathologically diagnosed breast lesions over the period of twelve years in a rural tertiary health care centre catering rural population. Results:Of the 552 cases examinedhistopathologically, 375 cases (67.9%) were benign lesions, 177 cases (32.1%) were malignant. Fibroadenoma was the commonest benign lesion, whereas infiltrating ductal carcinoma was the commonest malignant tumour. Incidence of phyllodes tumour was significantly higher compared to other studies. Overall sensitivity, specificity and diagnostic accuracy of FNAC and mammography were 95.9%, 98%, 96.6% and 84.7%, 78.5%,81.1% respectively. Conclusion:Histopathology plays an important role in diagnostic and therapeutic management of neoplastic breast lesionswith preoperative Triple test being an important supportive investigation in rapid diagnosis withfairly good sensitivity,specificity and diagnostic accuracyin neoplastic lesions. Significantly higher incidence of phyllodes tumor needs further investigation for causative mechanism.

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“…Although has the lower mortality compared to breast cancer, attention regarding management of this tumor is needed because it can affect the quality of life (QoL) and productivity of the sufferers (Goehring and Morabia, 1997). Pain in the region of the tumor, depressed and anxious feeling about the disease are the factors causing a decrease in the QoL in patients with benign breast tumors (Deane and Degner, 1998).…”

Section: Introductionmentioning

confidence: 99%

Jamu as Alternative Therapy to Improve Quality of Life (QoL) of Benign Breast Tumor Patients at Rumah Riset Jamu “Hortus Medicus”

Zulkarnain

Triyono

2017

IJCC

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Women with benign breast tumors could experience decreased in quality of life (QoL) due to pain and fear over the disease. This study aimed to investigate the QoL outcome in benign breast tumor patients who receive alternative treatment with jamu. A total of 26 female patients who came to Rumah Riset Jamu (RRJ) "Hortus Medicus" Tawangmangu in the period of September-December 2013 with complaints of breast tumor and met the inclusion criteria were included in this study. They were given Jamu formula for breast tumor and drank its water infusion twice daily for 16 weeks. Short Form-36 (SF-36) scores was measure at baseline, middle and the end of study. SF-36 is a tool to assess the QoL that has been widely used in health research. The mean scores of SF-36 is elevated in middle and the end of study compare to baseline. There were significant differences between the mean scores before and after treatment (paired t test, p<0,05). The results showed that Jamu had the potential to improve quality of life in patients with benign breast tumor.

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Epidemiology of Benign Breast Disease, with Special Attention to Histologic Types

Cited by 116 publications

References 97 publications

Benign breast disease heterogeneity: association with histopathology, age, and ethnicity

Benign breast disease heterogeneity: association with histopathology, age, and ethnicity

Correlation of Histopathological Study of Breast Lesions with cytology and mammography as a measure of internal quality and diagnostic accuracy

Jamu as Alternative Therapy to Improve Quality of Life (QoL) of Benign Breast Tumor Patients at Rumah Riset Jamu “Hortus Medicus”

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