Epidemiology of breast cancer in young women

Pollán, Marina

doi:10.1007/s10549-010-1098-2

Cited by 64 publications

(65 citation statements)

References 28 publications

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“…Birth characteristics, namely gestational age and birth length, are associated with maternal hormone levels and hormonal exposure in uterus, which increases the risk of breast cancer in adulthood. This exposure has a stronger effect in early breast cancers [34]. Ovarian hormones, that are the female sex steroid hormones, are major risk factors for breast cancer initiation and progression [35].…”

Section: The Effect Of Gestational Hormones On Breast Carcinogenesismentioning

confidence: 99%

Untitled

2017

IPCB

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Statistical reports have shown that breast and cervical malignancies are the most frequent cancers found in the general female population. As more women choose to delay childbearing, the frequency of associated breast cancer is increasing and it is now the most common pregnancy associated carcinoma. The influence of pregnancy on the risk of breast cancer is dependent on several maternal features related to reproductive, genetic and hormonal factors. The effects of pregnancy on the course of breast cancer and its prognosis are complex. It is known that breast cancer is more aggressive in younger women, but whether it is more aggressive during pregnancy in these same women is debatable. One of the reasons for which overall prognosis is diminished in pregnant women is because breast cancer is usually diagnosed at more advanced stage during pregnancy. Ranked second as the most common malignancy in the female population, after breast carcinoma, cancer of the cervix, where HPV (Human papillomavirus) infection is a necessary cause, has a high incidence of 8.9% in all races and a death rate of 2.8%. It is the second cause of cancer death in females aged between 20 and 39 years and it is now known that pregnancy can play an important role in cervical carcinogenesis as well. The aim of this review is to see how the hormonal changes occurring during pregnancy increases the risk of both breast and cervical cancers.

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Section: The Effect Of Gestational Hormones On Breast Carcinogenesismentioning

confidence: 99%

Untitled

2017

IPCB

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“…Breast cancer is the most-diagnosed type of cancer in female patients worldwide, accounting for ~25% of cancer cases in females; it has a higher prevalence in developed countries and an average age of onset of 50-70 years (1,2). Breast cancer in young female patients is increasingly common and presents a real problem for the diagnosis and adequate management of the disease in developing countries (2).…”

Section: Introductionmentioning

confidence: 99%

Breast cancer cases of female patients under 35ï¿½years of age in Togo: A series of 158ï¿½cases

et al. 2017

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Abstract. Breast cancer in young female patients represents a public health problem in developing countries. The objectives of the study were to study the epidemiological and histological characteristics of breast cancer in female patients under 35 years of age. This was a retrospective analytical study of a series of 158 cases of breast cancer in female patients under 35 years of age, conducted at the University Teaching Hospital of Lomé between 2000 and 2015. A total of 158 cases were collected, representing 36.2% (436) of all breast cancer cases. The average age of the patients was 30.9 years (range, 16-35 years). A family history of breast cancer at the 1st or 2nd degree was identified in 13.9% of cases. Genetic mutation studies were carried out for 7 patients, 5 of which revealed mutations (4 BRCA1 and 1 BRCA2). According to the locus, the cancer was located preferentially in the left breast in 88 cases (55.7%). Malignant mammary lesions were epithelial tumors (n=144 cases, 91.1%), infiltrating (n=125 cases, 79.1%) and non-infiltrating (n=19 cases, 12.0%). The other histological groups consisted of 8 cases of sarcomas (5 cases of angiosarcoma, 2 cases of fibrosarcoma and 1 case of Kaposi's sarcoma), 5 cases of lymphomas and one case of melanoma. Not otherwise specified infiltrating ductal carcinomas were SBR II and III in 43.2 and 35.2% of cases, respectively. The tumors classified as T4 were the most frequent (30.4%). Regarding the lymph node status, lymph node metastasis was noted in 22.8% of cases. Studies of hormone receptors were carried out in 23 patients and were positive for 11 patients: Estrogen receptor (ER)+plus progesterone receptor (PR)+(7 patients), ER+PR-(4 patients). Of the aforementioned 8 cases of sarcoma, 5 were angiosarcoma. The lymphomas were predominantly Burkitt's type for 4 cases. Mammary ultrasonography was performed in 45.6% of the patients and 54.4% underwent the combined ultrasonography and mammography. Ultrasound identified one or more sign of malignancy in 67 patients (42.4%), and combined ultrasonography and mammography classified 51.9% of lesions in BIRADS 4 and 5. The incidence of breast cancer in young Togolese patients is high. It is a disease distinguished by a delay in diagnosis, which contributes to the high number of cases that initially diagnosed at an advanced stage, particularly the high histo-prognosis grades of infiltrating ductal carcinoma. These results indicate a genetic origin; therefore, a thorough investigation into genetic mutations should be carried. In addition, further collaborative studies are required to verify these results.

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“…Breast cancer is the first cancer in women in the world; accounting for about 25% of female cancers with higher prevalence in developed countries and an average age of 50 -70 years [1] [2]. In Togo, it is the most common type of cancer in females with 27.1% of female cancers and even if in the two sexes [3] [4].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound-Guided Core Needle Biopsy of Breast Lesions: Results and Usefulness in a Low Income Country

Tchaou¹,

Darré²,

Gbande³

et al. 2017

OJRad

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Background: Core needle biopsy (CNB) under ultrasound guidance is an accepted standard of care for the diagnosis of breast lesions. It is safe, cost-effective and minimally invasive compared with surgical excision. Objective: The aim of this study was to evaluate the CNB's results regarding the procedure, complications, histopathological findings and their correlation with the imaging data and surgical histopathological findings. Method: A cross-sectional prospective and descriptive study of a consecutive series of ultrasoundguided CNB of breast lesions in women conduced from January 2015 to December 2016 at the Sylvanus Olympio university hospital of Lomé, in Togo. Results: There were 72 CNB performed under ultrasound guidance in women; from which 54 were retained for the study. The mean age was 44.9 years ± 9.8. 11.1% had a family history of breast cancer. Lesions were most often palpable (90.7%). They were located in the left breast in 54.7%. Lesions were categorized probably malignant or malignant (Birads 4 and 5) in 70.4% and probably benign (Birads 3) in 29.6%. Their mean size was 24.8 mm ± 7.6 at ultrasound. There were no major complications during the procedure. One CNB (1.9%) considered inconclusive was repeated. Histologically, invasive ductal carcinoma (61.1%) was the most common lesion. Fifty-three women underwent surgical procedure and histopathological confirmation. Ultrasound-guided CNB had a sensitivity of 97.5%, specificity of 100%, positive predictive value of 100%, negative predictive value of 92.8%, and an overall diagnostic accuracy of 98.1%. Breast Imaging Reporting and Data System (Birads) categorization had a sensitivity of 94.8%, specificity of 100%, positive predictive value of 100%, negative predictive value of 87.4%, and diagnostic accuracy of 96.2%. Conclusion: Ultrasound guided CNB represent accurate methods for the How to cite this paper: Tchaou, M., Darré, T., Gbandé, P., Dagbé, M., Bassowa, A., Sonhaye, L. and Agoda-Koussema, L.-K.

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Epidemiology of breast cancer in young women

Cited by 64 publications

References 28 publications

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Breast cancer cases of female patients under 35ï¿½years of age in Togo: A series of 158ï¿½cases

Ultrasound-Guided Core Needle Biopsy of Breast Lesions: Results and Usefulness in a Low Income Country

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