2021
DOI: 10.3389/fcvm.2021.669288
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Epidemiology of Cancer-Associated Thrombosis in Asia: A Systematic Review

Abstract: The epidemiology of cancer associated thrombosis (CAT) in Asia is less well-studied and differs from that in the western countries. Here, we systematically examine population based and hospital-based studies reported between 1995 and 2020 to understand the epidemiology of CAT in Asia. From population-based studies, the estimated incidence of VTE in cancer patients was 1.85–9.88 per 1,000 person-years. The incidence of CAT in Asia is significantly higher than non-cancer associated VTE in the general population … Show more

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Cited by 27 publications
(17 citation statements)
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“…Cancer patients have been shown to have a 5-7 fold increase of developing VTE [26,27], and for those patients who develop VTE with cancer, they have a significantly worse prognosis compared to cancer patients without VTE [28]. In our analysis, DVT/PE was more common in those with colorectal (28.1%), breast (22.7%), and lung cancer (21.9%); these findings are consistent with previous reports [23,29]. The augmented risk of VTE in patients with these cancers is likely complicated with requirement for major surgeries, which as well as further increasing the risk of VTE may also be associated with interruptions to anticoagulation.…”
Section: Discussionsupporting
confidence: 91%
“…Cancer patients have been shown to have a 5-7 fold increase of developing VTE [26,27], and for those patients who develop VTE with cancer, they have a significantly worse prognosis compared to cancer patients without VTE [28]. In our analysis, DVT/PE was more common in those with colorectal (28.1%), breast (22.7%), and lung cancer (21.9%); these findings are consistent with previous reports [23,29]. The augmented risk of VTE in patients with these cancers is likely complicated with requirement for major surgeries, which as well as further increasing the risk of VTE may also be associated with interruptions to anticoagulation.…”
Section: Discussionsupporting
confidence: 91%
“…Prophylactic anticoagulation was suggested for HHS hospitalization in Western countries, where the benefit and bleeding risk may not be the same as those found in Asia. Although some conditions (such as malignancy, pneumonia, and heart failure) are considered risk factors for VTE, prophylactic anticoagulants are not routinely prescribed in Taiwan [39][40][41][42]. Our study further supported that, unlike in Western populations, prophylactic anticoagulants seem unnecessary for patients with HHS in Taiwan.…”
Section: Discussionsupporting
confidence: 71%
“…Venous thromboembolism is known to increase mortality in patients with cancer 35 and, in this study, a 3.7‐fold increased risk of all‐cause death was observed in patients with baseline VTE versus those without baseline VTE. This is consistent with previous studies that report VTE to be a risk factor for mortality in a range of patients of different ethnicities with colorectal cancer 42–46 .…”
Section: Discussionmentioning
confidence: 55%