Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia

D’Onofrio, Valentino; Conzemius, Rick; Varda-Brkić, Dijana; Bogdan, Maja; Grisold, Andrea; Gyssens, Inge C.; Bedenić, Branka; Barišić, Ivan

doi:10.1016/j.meegid.2020.104263

Cited by 43 publications

(33 citation statements)

References 72 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among these, CHLDs seems to be mostly related to the occurrence of MDR phenotypes in A. baumannii . Although colistin was initially one of the leading antibiotics in the treatment of nosocomial infections caused by A. baumannii , a gradual increase of colistin resistance in clinical isolates, reaching even 100% in some studies has been revealed [ 19 , 21 , 25 ]. The origin of the clinical isolates demonstrates the wide dissemination of infections, the A. baumannii resistant strains being isolated mostly from tracheal aspirates, tracheal secretions, burn wounds, blood, urine or cerebrospinal fluid ( Table 1 ).…”

Section: Discussionmentioning

confidence: 99%

“…Analysis of AR of several A. baumannii isolates collected from different intensive care units revealed high resistance to the most commonly used antibiotics [ 16 , 17 ]. Several studies reported high carbapenem, aminoglycoside and colistin resistance of A. baumannii strains [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ] ( Table 1 ). The carbapenem resistance was associated with the overexpression of OXA-51 [ 32 ] and OXA-23 [ 33 , 34 ] class D carbapenemases as well as of metallo-β-lactamases (MBLs) [ 35 ].…”

Section: Ar Profiles Of a Baumannii Strainsmentioning

confidence: 99%

“…Studies conducted in recent years highlight the unique involvement of A. baumannii strains in increasing the severity of nosocomial infections and, implicitly, their associated morbidity and mortality rates. Analysis of the resistance profiles of A. baumannii strains reveals the spread of the MDR phenomenon to most common antibiotics, including last-line ones [ 21 , 25 ]. As an alternative to this phenomenon, studies have initially focused on the approach of combined therapies such as minocycline/tigecycline [ 231 , 232 ], colistin/tigecycline [ 233 ], colistin/rifampin [ 234 ], polymyxin B-combined therapy [ 235 ].…”

Section: Innovative Strategies For Treatment Of a Baumamentioning

confidence: 99%

“…Compared to the conventional use of antibiotics, production costs for AMPs are much higher, which is why research is moving towards peptides as short as possible with stable properties [ 261 ]. Some studies reveal the appearance of AMPs resistant strains [ 262 ], the best-known example being A. baumannii resistance to colistin [ 21 , 25 ]. Currently, research is aimed at developing technologies to improve the efficiency of AMPs in vivo, especially in terms of increasing the specificity against the infectious agents, decreasing cytotoxicity to mammalian cells, increasing stability and lowering production costs.…”

Section: Innovative Strategies For Treatment Of a Baumamentioning

confidence: 99%

See 3 more Smart Citations

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

et al. 2020

View full text Add to dashboard Cite

Antibiotic resistance is one of the biggest challenges for the clinical sector and industry, environment and societal development. One of the most important pathogens responsible for severe nosocomial infections is Acinetobacter baumannii, a Gram-negative bacterium from the Moraxellaceae family, due to its various resistance mechanisms, such as the β-lactamases production, efflux pumps, decreased membrane permeability and altered target site of the antibiotic. The enormous adaptive capacity of A. baumannii and the acquisition and transfer of antibiotic resistance determinants contribute to the ineffectiveness of most current therapeutic strategies, including last-line or combined antibiotic therapy. In this review, we will present an update of the antibiotic resistance profiles and underlying mechanisms in A. baumannii and the current progress in developing innovative strategies for combating multidrug-resistant A. baumannii (MDRAB) infections.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Ar Profiles Of a Baumannii Strainsmentioning

confidence: 99%

Section: Innovative Strategies For Treatment Of a Baumamentioning

confidence: 99%

Section: Innovative Strategies For Treatment Of a Baumamentioning

confidence: 99%

See 2 more Smart Citations

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

et al. 2020

View full text Add to dashboard Cite

show abstract

“…These enzyme-coding genes can be detected on either chromosomes or plasmids. The presence of OXA-23 has been widely reported in clinical isolates in many countries [17][18][19]. OXA-23-like β-lactamase enzymes have been found in outbreak isolates collected in the UK, East Asia, and South America, while OXA-40/24-like β-lactamases were found in the United States and Europe [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of OXA-Type β-Lactamase Genes among Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates in Thailand

et al. 2020

View full text Add to dashboard Cite

Carbapenem-resistant Acinetobacter baumannii (CRAB) is a critical health concern for the treatment of infectious diseases. The aim of this study was to investigate the molecular epidemiology of CRAB emphasizing the presence of oxacillinase (OXA)-type β-lactamase-encoding genes, one of the most important carbapenem resistance mechanisms. In this study, a total of 183 non-repetitive CRAB isolates collected from 11 tertiary care hospitals across Thailand were investigated. As a result, the blaoxa-51-like gene, an intrinsic enzyme marker, was detected in all clinical isolates. The blaoxa-23-like gene was presented in the majority of isolates (68.31%). In contrast, the prevalence rates of blaoxa-40/24-like and blaoxa-58-like gene occurrences in CRAB isolates were only 4.92% and 1.09%, respectively. All isolates were resistant to carbapenems, with 100% resistance to imipenem, followed by meropenem (98.91%) and doripenem (94.54%). Most isolates showed high resistance rates to ciprofloxacin (97.81%), ceftazidime (96.72%), gentamicin (91.26%), and amikacin (80.87%). Interestingly, colistin was found to be a potential drug of choice due to the high susceptibility of the tested isolates to this antimicrobial (87.98%). Most CRAB isolates in Thailand were of ST2 lineage, but some belonged to ST25, ST98, ST129, ST164, ST215, ST338, and ST745. Further studies to monitor the spread of carbapenem-resistant OXA-type β-lactamase genes from A. baumannii in hospital settings are warranted.

show abstract

Antibiotic Resistance Profile and Detection in ESKAPE Pathogens

Agrawal,

Patel

2024

ESKAPE Pathogens

View full text Add to dashboard Cite

Epidemiology of colistin-resistant, carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii in Croatia

Cited by 43 publications

References 72 publications

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

Antibiotic Resistance Profiles, Molecular Mechanisms and Innovative Treatment Strategies of Acinetobacter baumannii

Prevalence of OXA-Type β-Lactamase Genes among Carbapenem-Resistant Acinetobacter baumannii Clinical Isolates in Thailand

Antibiotic Resistance Profile and Detection in ESKAPE Pathogens

Contact Info

Product

Resources

About