Epidemiology of COVID-19 and Predictors of Outcome in Nigeria: A Single-Center Study

Ibrahim, Olayinka Rasheed; Suleiman, Bello Mohammed; Abdullahi, Suleiman Bello; Oloyede, Taofeek; Sanda, Abdallah; Gbadamosi, Maruf; Yusuf, Bashir O; Iliyasu, Rabilu Yandoma; Ibrahim, Lawal; Dawud, Adamu D; Bashir, Sulaiman Saidu; Okonta, Nwawueze Efam; Umar, Wasinda Francis; Tekobo, Abiodun Gbenga; Abubakar, Muhammadu Sani; Aminu, Bashir Taiye; Ibrahim, Shuaibu Onoruoyiza; Olaosebikan, Rasaq; Mokuolu, Olugbenga A.

doi:10.4269/ajtmh.20-0759

Cited by 15 publications

(27 citation statements)

References 34 publications

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“…Seventeen studies with 42,321 COVID-19 patients, of whom 632 (1.5%) had tuberculosis, reported on deaths due to COVID-19 [ 36 , 39 , 41 – 43 , 45 , 47 – 50 , 52 , 57 , 60 , 63 , 65 – 67 ]. All studies were conducted in high tuberculosis burden countries, except one from South Korea and another that combined data from multiple nations [ 42 , 43 ].…”

Section: Resultsmentioning

confidence: 99%

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

et al. 2021

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Objective The proportion of COVID-19 patients having active pulmonary tuberculosis, and its impact on COVID-19 related patient outcomes, is not clear. We conducted this systematic review to evaluate the proportion of patients with active pulmonary tuberculosis among COVID-19 patients, and to assess if comorbid pulmonary tuberculosis worsens clinical outcomes in these patients. Methods We queried the PubMed and Embase databases for studies providing data on (a) proportion of COVID-19 patients with active pulmonary tuberculosis or (b) severe disease, hospitalization, or mortality among COVID-19 patients with and without active pulmonary tuberculosis. We calculated the proportion of tuberculosis patients, and the relative risk (RR) for each reported outcome of interest. We used random-effects models to summarize our data. Results We retrieved 3,375 citations, and included 43 studies, in our review. The pooled estimate for proportion of active pulmonary tuberculosis was 1.07% (95% CI 0.81%-1.36%). COVID-19 patients with tuberculosis had a higher risk of mortality (summary RR 1.93, 95% CI 1.56–2.39, from 17 studies) and for severe COVID-19 disease (summary RR 1.46, 95% CI 1.05–2.02, from 20 studies), but not for hospitalization (summary RR 1.86, 95% CI 0.91–3.81, from four studies), as compared to COVID-19 patients without tuberculosis. Conclusion Active pulmonary tuberculosis is relatively common among COVID-19 patients and increases the risk of severe COVID-19 and COVID-19-related mortality.

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Section: Resultsmentioning

confidence: 99%

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

et al. 2021

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“…In-hospital mortality is high, in particular for patients with acute respiratory distress requiring ICU admission and mechanical ventilation [4][5][6][7][8]. In fact, the mortality rate reported in severe cases ranges from 50% to 100% [4][5][6][7][8]. However, to the best of our knowledge, apart from some reported cases [9,10], there have been no studies from Tunisia concerning severe cases of patients with COVID-19 requiring ICU admission.…”

Section: Introductionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

“…In Africa, there is little information available about the clinical characteristics and prognosis of COVID-19-infected patients [4][5][6][7][8]. Global mortality rates range from 4% to 5.6% [4][5][6][7][8]. In-hospital mortality is high, in particular for patients with acute respiratory distress requiring ICU admission and mechanical ventilation [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

“…Global mortality rates range from 4% to 5.6% [4][5][6][7][8]. In-hospital mortality is high, in particular for patients with acute respiratory distress requiring ICU admission and mechanical ventilation [4][5][6][7][8]. In fact, the mortality rate reported in severe cases ranges from 50% to 100% [4][5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics and outcomes of critically ill COVID-19 patients in Sfax, Tunisia

Bahloul¹,

Kharrat

Chtara

et al. 2022

Acute Crit Care

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Background: Africa, like the rest of the world, has been impacted by the coronavirus disease 2019 (COVID-19) pandemic. However, only a few studies covering this subject in Africa have been published. Methods:We conducted a retrospective study of critically ill adult COVID-19 patients-all of whom had a confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-admitted to the intensive care unit (ICU) of Habib Bourguiba University Hospital (Sfax, Tunisia).Results: A total of 96 patients were admitted into our ICU for respiratory distress due to COVID-19 infection. Mean age was 62.4±12.8 years and median age was 64 years. Mean PaO2/FiO2 ratio was 105±60 and ≤300 in all cases but one. Oxygen support was required for all patients (100%) and invasive mechanical ventilation for 38 (40%). Prone positioning was applied in 37 patients (38.5%). Within the study period, 47 of the 96 patients died (49%).Multivariate analysis showed that the factors associated with poor outcome were the development of acute renal failure (odds ratio [OR], 6.7), the use of mechanical ventilation (OR, 5.8), and serum cholinesterase (SChE) activity lower than 5,000 UI/L (OR, 5.9). Conclusions:In this retrospective cohort study of critically ill patients admitted to the ICU in Sfax, Tunisia, for acute respiratory failure following COVID-19 infection, the mortality rate was high. The development of acute renal failure, the use of mechanical ventilation, and SChE activity lower than 5000 UI/L were associated with a poor outcome.

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The incidence and mortality of COVID-19 related TB disease in Sub-Saharan Africa: A systematic review and meta-analysis

Tamuzi

Lulendo

Mbuesse

2022

Preprint

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Background Coronavirus disease 2019 (COVID-19) is also associated with other co-morbidities among with previous and current pulmonary tuberculosis (PTB). PTB is a risk factor for COVID-19, both in terms of severity and mortality, regardless of human immunodeficiency virus (HIV) status. However, there is less information available on COVID-19 associated with PTB in point of view incidence and mortality rates in sub-Saharan Africa (SSA) as a high burden TB region. This systematic review served to provide data synthesis of available evidence on COVID-19/PTB incidence and case fatality rates, and mortality rate found in clinical and post-mortem COVID-19/PTB diagnostics in SSA. Methods We conducted a systematic electronic search in the PubMed, Medline, Google Scholar, Medrxix and COVID-19 Global literature on coronavirus disease databases for studies including COVID-19 associated with PTB in sub-Saharan Africa. The main outcomes were the proportion of people with COVID-19 associated to current /or previous PTB and the case fatality associated to COVID-19/PTB. The combination method was based on methodological similarities in the included random effect model studies using Prometa 3 software. We further undertook sensitivity analysis and meta-regression. Results From the 548 references extracted by the literature search, 25 studies were selected and included in the meta-analysis with a total of 191, 250 COVID-19 infected patients and 11, 452 COVID-19 deaths. The pooled COVID-19/PTB incidence was 2% [1%-3%] and mortality of 10% [4%-20%]. The pooled estimates for case fatality rate among COVID-19/PTB were 6% [3%-11%] for clinical PTB diagnostic and 26% [14%-48%] for post-mortem PTB diagnostic. Meta-regression model including the effect sizes and cumulative COVID-19 cases (P= 0.032), HIV prevalence (P= 0.041) and TB incidence (P= 0.002) to explained high heterogeneity between studies. Conclusion As a summary, the incidence of TB associated with COVID-19 and case fatality rates are higher in SSA. However, COVID-19 associated to TB may be underreported in the studies conducted in SSA as the post-mortem TB diagnostic was higher. Large-scale cohort studies that adequately clear tool on previous and/or current TB diagnostic tools are required to confirmed COVID-19/TB incidence and case fatality in SSA.

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Epidemiology of COVID-19 and Predictors of Outcome in Nigeria: A Single-Center Study

Cited by 15 publications

References 34 publications

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

Active pulmonary tuberculosis and coronavirus disease 2019: A systematic review and meta-analysis

Clinical characteristics and outcomes of critically ill COVID-19 patients in Sfax, Tunisia

The incidence and mortality of COVID-19 related TB disease in Sub-Saharan Africa: A systematic review and meta-analysis

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