Epidemiology of Depression and Anxiety in Gout: A Systematic Review and Metaanalysis

Howren, Alyssa; Bowie, Drew; Choi, Hyon K.; Sharan, K.; Vera, Mary A. De

doi:10.3899/jrheum.190974

Cited by 17 publications

(13 citation statements)

References 50 publications

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“…Again, the small number of patients with gout led to low statistical power, which probably explains this discrepancy. We found an association of depression with gout but not hyperuricemia, which con rms previous work revealing an association of depression with gout and that determinants of depression in gouty patients were related to gout severity (24).…”

Section: Factors Associated With Goutsupporting

confidence: 89%

Epidemiology of gout and hyperuricemia in New Caledonia

Bardin

Magnat

Clerson³

et al. 2022

Joint Bone Spine

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Objectives. New Caledonia is a Paci c island of 270,000 inhabitants with mixed ethnicities, including Melanesians (39.1%), Polynesians (10.2%) and people from European ancestry (27.2%). This study aimed at determining the prevalence of gout and hyperuricemia in the general population and the various ethnicities of New Caledonia. Methods. A 3-degree random sample of the population aged 18 to 60 years was adjusted according to the 2014 New Caledonia census. Face-to-face planned interviews and physical measurements were performed by trained nurses. All consenting participants underwent capillary measurement of creatinine; all consenting men and only women older than 40 years underwent point-of-care uricemia testing . Gout was de ned by a validated algorithm. Two de nitions of hyperuricemia were used: capillary level equivalent to plasma uric acid level > 360 µmol/l (6 mg/dl) and > 420 µmol/l (7 mg/dl) and/or urate-lowering drug treatment for both thresholds.Results. We included 1.144 participants (adjusted mean age 37.7±12.0 years; adjusted sex ratio 50.4% men). The adjusted prevalence of gout was 3.3% (95% con dence interval 2.2-4.9). Prevalence was 6.7% (2.5-16.8), 4.1% (1.8-8.9), and 2.6% (1.4-4.7) for Polynesians, Europeans and Melanesians, respectively, and 1.9% (0.5-6.6) for other ethnicities. Prevalence of hyperuricemia, determined in 658 participants, was 67.0% (61.9-71.6) and 37.0% (32.3-42.0) for the 360-and 420-µmol/l thresholds, respectively, and was signi cantly greater for Polynesians and Melanesians than Europeans for both thresholds.Conclusions. The prevalence of gout and hyperuricemia in New Caledonia was high, including in patients of European descent. Key MessagesThis study is the rst to estimate the prevalence of gout in New Caledonia, a multiethnic Paci c island.The prevalence of gout was 3.3% (95% con dence interval 2.2-4.9) and varied across ethnicities.

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Section: Factors Associated With Goutsupporting

confidence: 89%

Epidemiology of gout and hyperuricemia in New Caledonia

Bardin

Magnat

Clerson³

et al. 2022

Joint Bone Spine

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“…Without clinical intervention, tophi can become developed within affected joints and or tissues and progressively damage them. Interestingly, the prevalence of gout flares, irrespective of SUA levels, has been linked to mental disorders [45,46]. Chronic heart failure and diabetes mellitus are more strongly associated with increased MSU crystal deposition in knees and feet/ankles than gout duration [47].…”

Section: Uric Acid and Goutmentioning

confidence: 99%

Why Does Hyperuricemia Not Necessarily Induce Gout?

Zhang

2021

Biomolecules

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Hyperuricemia is a risk factor for gout. It has been well observed that a large proportion of individuals with hyperuricemia have never had a gout flare(s), while some patients with gout can have a normuricemia. This raises a puzzle of the real role of serum uric acid (SUA) in the occurrence of gout flares. As the molecule of uric acid has its dual effects in vivo with antioxidant properties as well as being an inflammatory promoter, it has been placed in a delicate position in balancing metabolisms. Gout seems to be a multifactorial metabolic disease and its pathogenesis should not rely solely on hyperuricemia or monosodium urate (MSU) crystals. This critical review aims to unfold the mechanisms of the SUA role participating in gout development. It also discusses some key elements which are prerequisites for the formation of gout in association with the current therapeutic regime. The compilation should be helpful in precisely fighting for a cure of gout clinically and pharmaceutically.

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“…42 Systematic reviews also showed that gout disease progress could lead to depression, anxiety, and other mental health problems. 43 Therefore, gout management and control intervention are needed to prevent the worse impact of gout and help gout patients to cope with their illness.…”

Section: Discussionmentioning

confidence: 99%

Community gout management program needed for adult people in the rural area

Madyaningrum

Kusumaningrum

Wardani

et al. 2021

J Community Empowerment for Health

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Gout is one of the non-communicable diseases that can affect the quality of life. The high prevalence of gout is apparent in Indonesian research and records in primary health services. However, adult people's needs regarding gout management programs were barely explored. The study aimed to identify the association between the character of demographics, food consumption, and prevalence of gout in the rural areas in The Sleman Regency. This study is a quantitative study using a cross-sectional approach. Samples consisting of 109 adult people were chosen by purposive sampling with inclusion criteria: 1) residents of The Jaranan sub-village, Cangkringan, Sleman, D.I. Yogyakarta Province and 2) age over 25 years old. Data was collected through a survey using questionnaires adapted from the Indonesian Basic Health Survey Questionnaire, Gout Knowledge Questionnaire (GKQ) and Gout Assessment Questionnaire (GAQ), and food frequency form. Association between gout, food consumption, and knowledge were analyzed using the chi-square test.As a result, the prevalence of gout in adult people in rural areas was 18.35%. They have limited knowledge regarding gout diagnosis, treatment, and prevention (66,97%). Half of the respondents reported consuming food with medium content of purine such as tempeh (56%) and tofu (52%), and were not well-hydrated (63.3%). There was a significant relationship between gout and hypertension and meat consumption. Respondents reported they worried about the progress of gout (>70%) they will experience. In conclusion, the prevalence of gout is high in adult people in rural areas. The adult people who did not have formal education, hypertension, and meat consumption have a significant association with gout diseases. There is a need for a gout prevention program to maintain a healthy lifestyle and healthy diet, improve gout-related knowledge and control the progress of gout disease.

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Epidemiology of Depression and Anxiety in Gout: A Systematic Review and Metaanalysis

Cited by 17 publications

References 50 publications

Epidemiology of gout and hyperuricemia in New Caledonia

Epidemiology of gout and hyperuricemia in New Caledonia

Why Does Hyperuricemia Not Necessarily Induce Gout?

Community gout management program needed for adult people in the rural area

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